Early-morning, starch-rich meal improves glycemic control among type 2 diabetics

Type 2 diabetics inject themselves with insulin, a hormone that regulates the movement of sugar into liver, muscle and fat cells, up to four times a day. But insulin injections are linked to weight gain and the loss of control of blood sugar levels. This triggers a vicious cycle of higher insulin doses, continuous weight gain, a higher incidence of cardiovascular disease and other complications.

A new Tel Aviv University study finds that a starch-rich breakfast consumed early in the morning coupled with a small dinner could replace insulin injections and other diabetes medications for many diabetics.

The traditional diabetic diet specifies six small meals spread throughout the day. But our research proposes shifting the starch-rich calories to the early hours of the day. This produces a glucose balance and improved glycemic control among type 2 diabetics. We believe that through this regimen it will be possible for diabetics to significantly reduce or even stop the injections of insulin, and most of antidiabetic medications, to achieve excellent control of glucose levels. 

Prof. Daniela Jakubowicz of TAU's Sackler Faculty of Medicine and Wolfson Medical Center's Diabetes Unit

Prof. Jakubowicz is the lead author of the study, the result of a collaboration with Prof. Julio Wainstein and Dr. Zohar Landau of Wolfson Medical Center's Diabetes Unit and Prof. Oren Froy and Dr. Shani Tsameret of the Hebrew University of Jerusalem. The research was published in Diabetes Care in December.

According to the new research, our metabolism and biological clock are optimized for eating in the morning and for fasting during the evening and night, when we are supposed to be asleep. "But the usual diet recommended for type 2 diabetes consists of several small meals evenly distributed throughout the day -- for example, three meals and three snacks daily, including a snack before going to sleep to prevent a drop in sugar levels during the night," Prof. Jakubowicz says.

But the '6M-diet,' as this is called, has not been effective for sugar control, so diabetics require additional medication and insulin. And insulin injections lead to weight gain, which further increases blood sugar levels," Prof. Jakubowicz adds.

The researchers studied 29 type 2 diabetes participants and compared a new "3M-diet," more in alignment with our biological clock, with a control group on the traditional 6M-diet. The experimental 3M-diet comprises a meal of bread, fruits and sweets in the early hours of the morning; a substantial lunch; and a small dinner specifically lacking starches, sweets and fruits.

The group on the traditional 6M-diet did not lose weight and did not experience any improvement of sugar levels, requiring an increase in medication and insulin doses. But the group on the 3M-diet not only lost weight but also experienced substantially improved sugar levels.

"Their need for diabetic medication, especially for insulin doses, dipped substantially. Some were even able to stop using insulin altogether," adds Prof. Jakubowicz. "In addition, the 3M-diet improved the expression of biological clock genes. This suggests that the 3M-diet is not only more effective in controlling diabetes. It may also prevent many other complications such as cardiovascular disease, aging and cancer, which are all regulated by the biological clock genes."

The upregulation of the biological clock gene expression in the 3M-diet might be the mechanism behind its success, as it enhances insulin secretion and improves sugar delivery into the muscles, creating a balanced daytime and nocturnal glucose metabolism. The researchers are now investigating the role certain proteins play in breakfast foods consumed by diabetics.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

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Why Antioxidant Food Is Important For Weight Reduction?

Do your weight loss goals seem very far-fetched? It’s possible that your diet is the culprit. Let's look at this way – most nutritionists concur on the fact that weight loss is 90% diet and only 10% exercise. What they are saying is that even if you don’t ‘exercise’, you could still lose weight simply by eating sensibly.

So when you start to explore your diet for further answers, try to see if you are getting enough antioxidants. Wait how can antioxidants help with weight loss, aren’t they useful for your skin and heart and almost every other organ in the body.

The fact is while antioxidants are very good for your body, they also play a role in weight loss. The main role of antioxidants is to remove free radicals from the body. And your fat cells contain toxins such as free radicals. So when your body breaks fat cells down, the free radical level in the body goes up.

Once this happens, you start craving foods that are high in sugar and salt. And once you turn your cravings into action, your weight can shoot up. So to help curb out any unnecessary impulses with respect to weight loss goals, include these antioxidant-rich foods in your diet. The food items are -

Go Nut -
Be it the humble peanut, or the sophisticated macadamia nut – nuts are rich in antioxidants. Not just that, they also contain a high amount of healthy fats that promote satiety and are good for your heart. So you not only eat less overall but also keep your heart healthy. Note that most nuts are high in calories, so stick to a handful once a day.
    
Grapes -
This delicious fruit is rich in “resveratrol” – an antioxidant that removes free radicals that can lead to coronary artery disease. Grapes also increase the level of adiponectin, a protein that breakdown fat in the body. You can also consume them with Vitamin D to keep bone problems at bay.
    
 Spinach -
 Spinach is one of the most versatile food there is. You can add it to almost anything and make it taste good. From omelettes, pizzas, pasta to sandwiches – it can add flavour to any dish. But setting the taste aspect aside, spinach is rich in antioxidants like kaempferol and quercetin. The former has an anti-cancer effect on the body while the latter protects the body from cardiac and pulmonary disorders.

Green Tea -
Ah, how many times you must have heard that green tea is fantastic when it comes to weight loss. Well, there is plenty of truth to the statement. Green tea is packed with antioxidants that promote weight loss, the primary one being caffeine. Caffeine makes you feel full so that you don’t binge on unhealthy foods. So the next time you are hungry for a snack, just sip green tea.
 
If you drink green tea before you work out then it can increase the rate at which your body burns fat. If you don’t like its taste, then add a pinch of lime and honey. Remember not to add sugar, as most of its benefits will then be negated.

The bottom line is that you must include antioxidant-rich foods in your diet for not just weight loss but your overall health. So add some of the foods mentioned above to lose weight and become healthier.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     
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Coffee bean extract may be beneficial in reducing fat-induced inflammation

When coffee beans are processed and roasted the husk and silverskin of the bean are removed and unused, and often are left behind in fields by coffee producers.

Food science and human nutrition researchers have discovered  inflammation-fighting phenolic compounds — protocatechuic acid and gallic acid — in the silverskin and husk of coffee beans not only for their benefits in alleviating chronic disease but also in adding value to would-be ‘waste’ products from the coffee processing industry.

“This material from coffee beans is interesting mainly because of its composition. It’s been shown to be non-toxic. And these phenolics have a very high anti-oxidant capacity,” said  co-author of the study.

When fat cells of mice were treated with water-based extracts from coffee beans skins, the phenolic compounds reduced fat-induced inflammation in the cells and improved glucose absorption and insulin sensitivity.

The findings show promise for these bioactive compounds, when consumed as part of the diet, as a strategy for preventing obesity-related chronic illnesses, such as Type 2 diabetes and cardiovascular disease.

For the study, the fat cells and immune cells were cultured together to recreate the ‘real-life’ interaction between the two cells.

When obesity-related inflammation is present, the fat cells and immune cells work together — stuck in a loop–to increase oxidative stress and interfere with glucose uptake, worsening the situation.

In order to block this loop and prevent chronic disease, the researchers’ goals are to eliminate or reduce as much inflammation as possible in order to allow glucose uptake to be facilitated, as well as to have healthy cells that will produce adequate insulin.

The researchers also stressed the positive impact on the environment of using the coffee bean by-products.

During coffee processing, the bean is separated from the husk, the external outer layer of the bean. After the bean is roasted, the silverskin layer is separated.

“It’s a huge environmental problem because when they separate this husk after processing, it usually stays in the field fermenting, growing mold, and causing problems,” explained one of the researcher.

Worldwide, 1,160,000 tonnes of husk are left in fields per year, potentially causing contamination.

Additionally, 43,000 tonnes of silverskin is produced each year, which, the researcher  adds, may be easier to utilize because it stays with the bean as it is exported to different countries to be roasted.

this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   
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https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
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Fat cells may explain why melanoma becomes 'aggressive and violent'

New research may have found the answer to a question that has preoccupied scientists for years: What makes melanoma become 'aggressive and violent'? The answer brings with it some important therapeutic implications.

Despite making up only 1% of all skin cancers, melanoma  is the cause of most skin cancer-related deaths.

According to doctors' estimates, in 2019 and in the United States, doctors will diagnose 96,480 new cases of melanoma, and 7,230 people will die from the disease.

When the cancer is localized, or in situ, the 5 year outlook is close to 100%. However, as the cancer progresses, the survival rate can drop as low as 23%.

But what causes melanoma to become aggressive? A new study has found an intriguing answer.

How fat cells help melanoma advance

Researchers collected dozens of tissue samples from people who had been diagnosed with melanoma.

Examining the biopsy samples revealed that, at first, tumors grow in a "lateral" phase in the upper epidermal layer of the skin. Although this stage is proliferative, it is highly treatable.

However, at a certain point, tumors enter a "vertical," more aggressive, stage, wherein they start to invade the deeper layers of skin that contain fat. So, the researchers asked, what causes this "metastatic switch"?

Clinical analyses of in situ melanoma cells — from melanoma in its highly treatable stage — showed that adipocytes, or fat cells, which usually reside in the deeper layers of the skin, had risen to the upper dermis layer, close to melanoma cells. This event correlated with the aggressiveness of the disease.

Furthermore, co-culture experiments of fat cells and melanoma cells revealed that fat cells secrete two cytokines that triggered the metastatic switch.

Namely, they secreted interleukin-6 and tumour necrosis factor-alpha, which are cytokines, or proteins, that have the ability to alter gene expression.

"We asked ourselves what fat cells were doing [near melanoma cells] and began to investigate," explains the Prof.

"We placed the fat cells on a petri dish near melanoma cells and followed the interactions between them."

"Our experiments have shown that the main effect of cytokines is to reduce the expression of a gene called miRNA 211, which inhibits the expression of a melanoma receptor of [transforming growth factor-beta (TGF-beta)], a protein that is always present in the skin," reports the Prof.

"The tumor absorbs a high concentration of TGF-beta, which stimulates melanoma cells and renders them aggressive."

Returning melanoma to its 'calm' state

"It is important to note that we found the process reversible in the laboratory: When we removed the fat cells from melanoma, the cancer cells calmed down and stopped migrating," explains Prof. Levy.
So, the researchers also used a mouse model of melanoma to see if they could block this metastatic process. Repressing miRNA 211 causes melanoma to metastasize to distant organs in the body, while expressing the gene stopped the metastasis.

The team went on to experiment with drugs, which, although never used to treat melanoma specifically, had the potential to inhibit cytokines and TGF-beta.

"We are talking about substances that are currently being studied as possible treatments for pancreatic cancer  and are also in clinical trials for prostate, breast, ovarian, and bladder cancers," notes the Dr.

"We saw that they restrained the metastatic process and that the melanoma returned to its relatively 'calm' and dormant state."
  

"We have answered a major question that has preoccupied scientists for years: What makes melanoma change form, turning aggressive and violent?" says the Prof.

"Locked in the skin's outer layer, the epidermis, melanoma is very treatable; it is still stage 1, it has not penetrated the dermis to spread through blood vessels to other parts of the body, and it can simply be removed without further damage," continues the Prof.

"Melanoma turns fatal when it 'wakes up,' sending cancer cells to the dermis layer of skin below the epidermis and metastasizing in vital organs."

"Blocking the transformation of melanoma is one of the primary targets of cancer research today, and we now know that fat cells are involved in this change."

"Our findings can serve as a basis for the development of new drugs to halt the spread of melanoma — therapies that already exist, but were never used for this purpose," the Prof. concludes, adding that in the future, the researchers plan to collaborate with pharmaceutical companies in order to develop such treatments.

 

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                  https:// kneereplacement-stickclub.blogspot.com/                                                                      FOR CROCHET DESIGNS                                                                                                    

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Weight Gain Or Tumour?

A California man is on the mend after having a 77-pound tumor removed from his abdomen that he thought was “just” a beer belly.

The man eventually went to the doctor this summer to get checked out. His friends teased him about his beer belly, even though he didn’t drink beer, and his stomach and weight didn’t seem to change when he exercised even though his arms were getting thinner, according to a news release from the hospital, where he sought care. His stomach was also hard.

He was eventually diagnosed with a retroperitoneal liposarcoma, a cancer that starts in the fat cells at the back of the abdomen. He eventually had the tumor removed in a complicated six-hour operation, and a week later, he was more than 100 pounds lighter.

He is hardly the first person to write off his unexplained weight gain only to later find out that it was due to a tumor. In May, an Alabama woman had a 50-pound ovarian cyst removed that she initially thought was just due to weight gain, according to report. The internet is filled with stories like these. 

So, how can someone know if their weight gain is due to dietary or other issues versus a tumor? “It is not always easy,” says a cancer specialist. “But some clues that this might be something different than just [regular] weight gain is that the weight gain is asymmetric or happening very fast.”

This kind of tumor usually doesn’t cause pain, “but patients can notice a change in their bowel habits (usually more sluggish) and feeling full more quickly,” the Dr. says. “Also when lying down, they might notice feeling uncomfortable in certain positions or having a sensation of fullness on one side.” A person’s clothes may also not fit the way they used to and may be tighter on one side than the other, she says. “It is possible that if a tumor is large, it may cause pressure on the blood vessels to the legs and there can be fluid retention of the legs. One should be concerned especially if there is swelling in one leg and not the other,” she adds.

“There’s no way in terms of symptoms to definitively say ‘This is due to cancer and this is not,’”  a surgical oncologist says. “Any unexplained change in weight should be checked out.”

Of course, there could be many other reasons why you’re gaining weight, including a thyroid condition, so it doesn’t hurt to check in with your primary care physician for a workup if you’ve noticed ongoing unexplained weight gain. “I would also seek medical attention if you feel the weight is going on one side and not the other, or you notice you are feeling full more quickly and truly are eating less food but continue to gain weight,” the Dr. says. “The challenge is that many of these tumors can be slow growing, so changes may not be obvious.”

Regardless, if you notice that something might be off, “don’t let things with your body that seem odd to you go by,” the Dr. advises.

It is always best to seek medical advise the moment we notice something abnormal in us, may be food or bowel movements, can be speech, trouble swallowing. feeling full eating little, blood in urine/ stools , sudden blurred vision, and so on.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                                                                                                                                                                                                                        PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                                             FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                                                                                             https:// kneereplacement-stickclub.blogspot.com/                                                                                       FOR CROCHET DESIGNS                                                                                                                                                                                                                                 https://gscrochetdesigns.blogspot.com