First human mini-stomach grown in laboratory

The first functional 3D human stomach tissue in a laboratory has been grown by scientists using pluripotent stem cells.

Scientists at Cincinnati Children's Hospital Medical Center used human pluripotent stem cells, which can become any cell type in the body, to grow a miniature version of the stomach.

In collaboration with researchers at the University of Cincinnati College of Medicine, they used laboratory generated mini-stomachs to study infection by H pylori bacteria, a major cause of peptic ulcer and stomach cancer.

This first-time molecular generation of 3D human gastric organoids presents new opportunities for drug discovery and studying some of the underpinnings of obesity related diabetes, according to Jim Wells, principal investigator.

It also is the first time researchers have produced 3D human embryonic foregut — a promising starting point for generating other foregut organ tissues like the lungs and pancreas, he said.    THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.








PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-

HTTP:GSEASYRECIPES.BLOGSPOT.COM/

FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-

HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/

FOR CROCHET DESIGNS

HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM

Hypoglycemia & How it Affects Our Lives

Have you noticed that when you (or a loved-one) wait too long between meals, you become irritable, confused, nauseated or fatigued? That means you’re most likely experiencing symptoms of postprandial hypoglycemia.

What is postprandial hypoglycemia? Postprandial hypoglycemia (also known as “Reactive hypoglycemia”) translates as “Low blood sugar which occurs after eating”. In postprandial hypoglycemia, a non-diabetic person experiences reoccurring symptoms similar to those of medical hypoglycemia. Medical hypoglycemia is a state where there are abnormally low levels of glucose in the blood, resulting in an inadequate supply of it to the brain. What causes hypoglycemia? Postprandial hypoglycemia usually manifests about 4 hours after consuming a large carbohydrate meal or a high consumption of glucose. Healthy adults maintain a blood glucose level of around four mmol/L when between meals. If the level drops below four mmol/L, hypoglycemic symptoms may appear. The  (NIH) states that "The causes of most cases of reactive hypoglycemia are still open to debate. Some researchers suggest that certain people may be more sensitive to the body’s normal release of the hormone epinephrine, which causes many of the symptoms of hypoglycemia. Others believe deficiencies in glucagon secretion might lead to reactive hypoglycemia.”

Symptoms: Double vision or blurry vision Unclear thinking Sleeping Trouble Heart palpitation or fibrillation Fatigue Dizziness Light-headedness Sweating Headaches Depression Nervousness Muscle twitches Irritability Tremors Flushing Craving sweets Increased appetite Rhinitis Nausea, vomiting Panic attack Numbness/coldness in the extremities Confusion Coma can be a result in severe untreated episodes

Treatment You can purchase a blood glucose meter in most pharmacies if you wish to test the levels of glucose in your blood. The NIH recommends taking the following steps: Eat small meals and snacks every 3 hours. Avoid or limit sugar intake Eat a variety of foods, including meat, poultry, fish, or nonmeat sources of protein, foods such as whole-grains, fruits, vegetables, and dairy products Prefer high-fiber foods Regular Exercise (exercise increases sugar uptake which decrease excessive insulin release) Foods you should avoid: Sugar (white / dark) Honey and molasses Corn, rice, maple and fruit syrups Candies, cookies and chocolate Cakes, pies, pastries and muffins Milk, ice cream, frozen yogurt and pudding Jelly, jam Alcoholic beverages Carbonated drinks Caffeinated drinks Potatoes, white rice Noodles, pastas and spaghetti Dried Fruit, grapes, figs, bananas, dates and plums Grape and Prune Juice Dishes containing corn starch and refined flour Artificial sweeteners Sweetened condiments Starchy vegetables (like corn) Foods that are good for you: Wholegrain breads, cereals, crackers made with little and no sugars Fresh fruits and vegetables Decaff coffee and tea Carbonated and regular water Brown rice and whole grain pasta Raw nuts, unsweetened nut butter Organic poultry, meats, fish and shellfish    THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES. PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG- HTTP:GSEASYRECIPES.BLOGSPOT.COM/ FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG- HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/ FOR CROCHET DESIGNS HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM

Psoriatic Arthritis

What Is Psoriatic Arthritis?

If you have psoriasis -- a skin condition that makes thick patches of itchy red, white, or silvery skin -- you could get psoriatic arthritis. With psoriasis, your body's immune system goes into overdrive, causing inflammation of your skin. With psoriatic arthritis, it also attacks your joints, making them swollen and stiff. Getting diagnosed early can help you prevent or limit joint damage.

Who Gets It?

About 85% of people who get psoriatic arthritis already have psoriasis. Only about 15% get it without any history of psoriasis. If you have psoriasis and you notice joint pain, see a doctor who specializes in arthritis for a diagnosis.

Causes

We don’t know exactly what causes psoriatic arthritis. It's most likely passed on in families. About 40% of people who have it have a close relative who has it, too. Infections like strep throat may also have some links to psoriasis.

Warning Signs

Stiff, puffy, sausage-like fingers or toes are common, along with joint pain and tenderness. The psoriasis flares and arthritis pain can happen at the same time or location, but not always. You may also have:

    Dry, red skin patches that may have silvery-white scales
    Pits in your nails or nails that separate from the nail bed
    Fatigue
    Eye redness and pain

Back and Heel Pain

One form of psoriatic arthritis can inflame the joints in your spine. It’s called spondylitis, and it causes back and neck pain. Another form causes pain, tenderness, or swelling where tendons attach to your bones, like in your heel. It can also affect your hands, knees, hips, or chest.

Get Diagnosed Early

An arthritis specialist (rheumatologist) can diagnose psoriatic arthritis and treat it early. She will look at your joints and skin, noticing any swelling, pain, or nail changes. Your doctor may also order X-rays, MRIs, ultrasounds, or CT scans to check for joint damage. Blood, joint fluid, or skin samples can rule out other forms of arthritis.

 Psoriatic Arthritis Treatment

If your case is mild, you may need only a drugstore anti-inflammatory medicine like Advil or Aleve when your joints are sore. Corticosteroid injections can also help. Prescription drugs called DMARDs (disease-modifying antirheumatic drugs) relieve severe symptoms. They also slow or stop psoriatic arthritis from getting worse and ease skin problems. Your doctor may also suggest separate treatments for your psoriasis.

Treatment With Biologics

Biologics are some of the newer drugs used to treat psoriatic arthritis. Your doctor may prescribe one for you if other drugs aren't working. Biologics target immune cells that cause psoriasis and psoriatic arthritis. They can slow down damage to your joints as well as ease symptoms like joint pain, swelling, and scaling of your skin.

Exercise

Psoriatic arthritis pain is different than regular arthritis pain. The pain and swelling get worse when you're not active. Exercise can help prevent pain. Swimming and walking in a pool are good no-impact cardio workouts that also build strength and flexibility. Just shower right after you get out of the pool so the chlorine doesn't dry your skin. If you're not sure how to get moving, a physical therapist can help.

Fatigue

You may get tired if you have psoriatic arthritis. Pain medication helps. Other ways to beat fatigue: 

    Get up later in the morning, or take an afternoon nap.
    Save your energy for activities that are most important or that you enjoy most.
    Ask family or friends to help.
    Exercise regularly to boost your energy and sleep better at night.

Pain

Try heat and cold therapy to relieve pain. Soak in a bath, take a shower, or use a hot pack to relax your aching muscles and relieve soreness. Apply a bag of ice or frozen vegetables wrapped in a towel to numb a joint and relieve swelling.

About one-third of people with psoriatic arthritis have a mild form of the disease that stays stable over time. Others need long-term treatment for their symptoms. Medicines have come a long way, so even severe psoriatic arthritis doesn't have to be disabling. Pro golfer Phil Mickelson (a spokesman for the drug Enbrel) credits an early diagnosis and good treatment with helping him overcome near-crippling pain to stay in the game.


THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.








PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-

HTTP:GSEASYRECIPES.BLOGSPOT.COM/

FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-

HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/

FOR CROCHET DESIGNS

HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM

Kitchen Tips For those suffering from Rheumatoid Arthritis

Cook Comfortably With RA

A few tweaks to your kitchen setup can keep RA from ruining your joy of cooking. Start by finding a sturdy stool that's the right height for sitting in front of your counter or stove-top. Now you won't have to stand while chopping or stirring.

Use a Toaster Oven

When possible, do your baking, broiling, and reheating in a toaster oven or counter-top microwave. This will spare your joints the stress of stooping to use a traditional oven or reaching up to use an overhead microwave.

Hang Your Pots and Pans

Keep yourself from bending over by storing the items you use the most at arm level. Instead of crouching to dig pots and pans out of cabinets, hang them on wall hooks or from a ceiling rack.

Store Ingredients in Easy Reach

Keep cooking oil, seasonings, and other common ingredients on your counter so they're always within comfortable reach. Store sugar, flour, coffee, and tea on the counter in containers with easy lift-off lids.

Switch to Ergonomic Utensils

A few well-designed kitchen utensils can make a big difference. An ergonomic knife with a large handle lets you use your body weight to slice instead of your hand or wrist. Padded handles make spatulas and other utensils more comfortable to grip. And two-handled pots and pans are a must. Distributing the weight across both hands makes carrying easier.

Go Electric

The repeated motions of chopping, mincing, or mixing can be hard on your joints. Let small electric appliances do some of the work for you. An immersion blender or handheld drink mixer can get your whisking done quickly and painlessly. A food processor is perfect for mincing and shredding. And an electric jar opener takes away the strain of twisting off lids.

Put Your Fridge on a Leash

If you have trouble opening the door to your fridge, tie a scarf or leash around the handle and knot it into a circle. Hook your arm through the loop and pull the door open with your upper body.

Fill Pots Cup by Cup

When you need to fill a pot, set it on the stove empty. Use a measuring cup or pitcher to transfer water from the sink in amounts you can manage. If your sink is far from your stove, set your pot on a rolling plant stand. Roll it up to the sink, fill it cup by cup, and then roll in back to the stove.

Use a Slow Cooker

Don't spend a lot of time standing over the stove to make meals. Let a slow cooker do the work for you. Add pre-sliced frozen vegetables, meat, liquid, and seasoning. Then you can be kitchen-free until your hot, home-cooked meal is ready.

Wash Dishes by Hand

Forget all that bending to load and unload a dishwasher. Hand-wash your dishes, and let the warm water soothe your joints. Set clean dishes in a rack to air dry, so you won't have to towel them off.

Cook Once, Eat Twice

Whenever you cook, double the ingredients so you have a second meal to freeze. This gives you an easy solution for those days when your joints are particularly achy -- or when you just feel like a night off from cooking.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.








PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-

HTTP:GSEASYRECIPES.BLOGSPOT.COM/

FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-

HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/

FOR CROCHET DESIGNS

HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM

Hair disorder could signal dental decay

Keratins, proteins associated with strong hair, are important for tooth enamel, the findings showed.
Individuals with mutations in hair keratin genes are prone to cavities, the findings showed.

The researchers found that tooth enamel from individuals with keratin mutations had abnormal structure that resulted in weakness.

"Our results identify a genetic locus that influences enamel structure and establishes a connection between hair disorders and susceptibility to dental caries," said Maria Morasso from National Institutes of Health in the US.

Tooth enamel is the hardest substance in the human body and has a unique combination of hardness and fracture toughness that protects teeth from dental caries, the most common chronic disease worldwide.

"Epithelial hair keratins, which are crucial for maintaining the integrity of the sheaths that support the hair shaft, are expressed in the enamel organ and are essential organic components of mature enamel," the researchers said.

The study involved genetic and intra-oral examination data from 386 children and 706 adults.
The researchers found that individuals harbouring known hair disorder-associated polymorphisms in the gene encoding keratin 75 (KRT75), KRT75A161T and KRT75E337K, are prone to increased dental caries.

A functional keratin network is required for the mechanical stability of tooth enamel, the findings showed.

The study appeared in the Journal of Clinical Investigation.

 THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.








PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-

HTTP:GSEASYRECIPES.BLOGSPOT.COM/

FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-

HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/