Eating Without Gaining Weight Might Now Be Possible!

There will be many like me, foodies, who love to eat their heart's content and still not gain a pound. Some may say, wishful thinking, why not? as soon, it may happen, thanks to genetic studies that are happening all over the world. Soon, we’ll be able to find out. Researchers  have identified a gene called RCANI, the inhibition of which could allow a person to eat as much as they want without getting fat.

The research reports, was based on the understanding that increasing non‐shivering thermogenesis (NST), which expends calories as heat rather than storing them as fat, is a well-championed way to combat obesity and metabolic disease. However, certain innate mechanisms constrain the capacity for NST. Regulator of Calcineurin 1 (RCAN1), one such gene, suppresses two distinctly different mechanisms of non‐shivering thermogenesis (NST).

After conducting the study on mice, the researchers found: Mice deficient for RCAN1 have an elevated metabolic rate and are resistant to diet‐induced obesity.

It is hoped that inhibiting this gene in humans could lead to similar results and help tackle obesity.
As reported , a Prof. who led the study explained that they looked at a variety of different diets with various time spans from eight weeks to almost six months, and observed health improvements in all cases where there was an absence of the RCAN1 gene.

We know a lot of people struggle to lose weight or even control their weight for a number of different reasons. The findings in this study could mean developing a pill which would target the function of RCAN1 and may result in weight loss.

Inhibiting the gene could convert white fat to healthier brown fat in humans, eradicating many health problems in them.

"In light of our results, the drugs we are developing to target RCAN1 would burn more calories while people are resting. It means the body would store less fat without the need for a person to reduce food consumption or exercise more," the Prof. added.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                                                                                                                                                                                                                        PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                                             FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                                                                                             https:// kneereplacement-stickclub.blogspot.com/                                                                                       FOR CROCHET DESIGNS                                                                                                                                                                                                                                 https://gscrochetdesigns.blogspot.com

New skin patch may help reduce obesity

Scientists have developed a new type of skin patch that may help reduce bulging tummy fats and obesity by delivering drugs that turn energy-storing white fat into energy-burning brown fat.
This innovative approach developed by scientists, reduced weight gain in mice on a high fat diet and their fat mass by more than 30 per cent over four weeks. 

The new type of skin patch contains hundreds of micro- needles, each thinner than a human hair, which are loaded with the drug Beta-3 adrenergic receptor agonist or another drug called thyroid hormone T3 triiodothyronine. 

When the patch is pressed into the skin for about two minutes, these micro-needles become embedded in the skin and detach from the patch, which can then be removed. 

As the needles degrade, the drug molecules then slowly diffuse to the energy-storing white fat underneath the skin layer, turning them into energy-burning brown fats. 

Brown fats are found in babies and they help to keep the baby warm by burning energy. As humans grow older, the amount of brown fats lessens and is replaced with visceral white fats. 

Published in the journal, this approach could help address the worldwide obesity problem without resorting to surgical operations or oral medication which could require large dosages and could have serious side effects. 

"With the embedded microneedles in the skin of the mice, the surrounding fats started browning in five days, which helped to increase the energy expenditure of the mice, leading to a reduction in body fat gain," said the scientist.

Obesity which results from an excessive accumulation of fat is a major health risk factor for various diseases, including heart disease, stroke and type-2 diabetes. 

The World Health Organisation (WHO) estimated that 1.9 billion adults in the world were overweight in 2016 with 650 million of them being obese, researchers said. 

"What we aim to develop is a painless patch that everyone could use easily, is unobtrusive and yet affordable," said the scientist. 

"Most importantly, our solution aims to use a persons own body fats to burn more energy, which is a natural process in babies," the scientist said. 

The treated mice also had significantly lower blood cholesterol and fatty acids levels compared to the untreated mice.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.    
 
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This Needle-Covered Patch Dissolves Excess Body Fat Wherever You Stick It

A skin patch that effectively melts excess body fat wherever you decide to apply it sounds too good to be true, but this thing actually exists, thanks to new research.

The medicated patch uses an array of skin-piercing micro-needles to deliver nano-particles of drugs to the body, and while it hasn't yet been tested on humans, trials with mice show it reduces fat by as much as 20 percent in treated areas.

Developed by researchers, the skin patch doesn't just hold promise (and potential riches) for the cosmetics industry – it could one day help us to fight conditions like obesity and diabetes.

The way it works is to do with how our bodies store fat, which largely comes down to two kinds of fat cells: white fat and brown fat.

Brown fat is often thought of as 'good fat' because it readily breaks down and produces heat – which is why newborns have a lot of it, given they need help regulating their body temperature.

 Unfortunately for grown-ups, we don't have as much brown fat, and are instead saddled with ungainly deposits of white fat around our bodies, which is used for long-term energy storage, but not so easily burned.

In recent years, there's been a huge amount of scientific effort focused around bridging the gap between these two kinds of fat – or, more accurately, learning how to convert energy-storing white fat into energy-burning brown fat.

 A number of studies have shown success in triggering the transformation – sometimes called browning – but from a health care perspective, there's a problem.

"There are several clinically available drugs that promote browning, but all must be given as pills or injections," says one of the team.

"This exposes the whole body to the drugs, which can lead to side effects such as stomach upset, weight gain, and bone fractures. Our skin patch appears to alleviate these complications by delivering most drugs directly to fat tissue."

 This is possible due to the patch's grid of microscopic needles, which deliver browning chemicals under the skin wherever white fat is being stored.

 In their study, the researchers used two different browning drugs, rosiglitazone (aka Avandia) and a chemical called CL316243, which has previously been shown to brown white fat in mice.
 
First up, the drugs are encased in nanoparticles, each measuring about 250 nanometres (nm) in diameter – for reference, a human hair is approximately 100,000 nm wide, so we're talking really, really small.

 These nano-particles are then deployed in the patch, and when the micro-needles painlessly pierce the skin, the nano-particles are delivered into the tissue directly under the patch, where they dissolve.

 "The nano-particles were designed to effectively hold the drug and then gradually collapse, releasing it into nearby tissue in a sustained way instead of spreading the drug throughout the body quickly," explains one of the researchers.

In experiments with obese mice, patches were applied every three days for a total of four weeks. Treated mice had two patches applied on different sides of their bodies: one containing a browning drug, and the other containing empty nanoparticles.

 The results showed that the patches containing either rosiglitazone or CL316243 produced a 20 percent reduction in fat on the animals' treated side (compared to the empty nanoparticles patch).

 They also showed lower fasting blood glucose levels than control animals who were also only given patches containing no browning drugs.

In lean mice the treatment also offered benefits, increasing animals' oxygen consumption compared to untreated controls.

 Of course, there's no guarantee humans wearing the patch would see the same results, but it's another promising step forward as scientists gradually uncover the mechanisms that control brown and white fat production.

 The team are currently researching which drugs, or which combination of drugs, might work best to enable this kind of localised browning – as it's possible the right chemical might even be able to improve on the already impressive 20 percent fat reduction they've seen so far.

 "Many people will no doubt be excited to learn that we may be able to offer a noninvasive alternative to liposuction for reducing love handles," says a researcher.

 "What's much more important is that our patch may provide a safe and effective means of treating obesity and related metabolic disorders such as diabetes."

 While at present there are no firm plans to release the patch for use by people, it's quite possible that something like this might become available in the future once more a lot more research and safety tests are completed.

 Until that fateful day, there's always fish oil.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.
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New Molecule To Fight Obesity Identified

Activating the estrogen -- the primary female sex hormone -- receptor-beta protein with a chemical has the potential to increase metabolism as well as help reduce obesity, say researchers including one of Indian-origin.

The findings showed that the activation of a chemical called beta-LGND2 by the estrogen receptor-beta can help reduce obesity and metabolic diseases in mice by converting bad fat (white fat) into good fat (brown fat).

This is significant as brown fat increases metabolism and may facilitate weight loss, the researchers said.

"Although there is a general misperception that obesity is not a life-threatening condition, obesity is the underlying cause for several diseases that could result in mortality," said Ramesh Narayanan, a researcher at the University of Tennessee in the US.

"Safe and effective treatment for obesity is highly needed, and targeting estrogen receptor-beta might be one of the strategies to safely combat obesity," Narayanan added.

To make their discovery, Narayanan and colleagues used three groups of mice.

One group was fed with normal rodent diet, while two groups were fed with high-fat diet to make them obese. One of the two high-fat diet-fed groups was treated with beta-LGND2.

The beta-LGND2-treated mice were significantly leaner than the other mice fed on high-fat diet and they also had higher body temperature and oxygen consumption, indicating higher metabolism rate.

The research was published online in The FASEB Journal.

this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.

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This protein can resist weight gain despite high-fat diet

Not been able to fight off excess belly fat despite exercise and diet control? High levels of a particular protein can help.

Higher levels of Glial cell line-derived neurotrophic factor (GDNF for short) that keep body’s systems in balance may help fight the weight gain and health problems caused by high-fat diet.

“Our findings show that GDNF may cause increased calorie burn in both brown and white fat cells and in muscle tissue,” said Simon Musyoka Mwangi from Kenyatta University, (KU) in Nairobi, Kenya.

The protein also helps develop and maintain nerve cells responsible for a host of bodily functions such as digestion and muscle control.

In this study on mice, researchers looked specifically at how the increased presence of GDNF might affect obesity caused by a high-fat diet.

They found that the GDNF-mice fed a high-fat diet resisted diet-induced weight gain, visceral

(around the organs) fat development, fatty liver, high lipid (fat) levels in the blood and insulin resistance.

The GDNF mice also experienced improved insulin sensitivity and increased calorie burn compared to control mice on a high-fat diet.

“The research suggests that GDNF and its receptors may be unique and effective targets for obesity prevention and treatment therapies,” Mwangi noted in a paper published in the American Journal of Physiology-Gastrointestinal and Liver Physiology.

ps- this is only for information, always consult you physician before having any particular food/ medication/exercise/other remedies.

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