Researchers developing new therapy to treat Parkinson's disease

Cell replacement may play an increasing role in alleviating the symptoms such as movement problems and memory loss of Parkinson's disease (PD), researchers say. The most common PD treatment today is based on enhancing the activity of the nigrostriatal pathway in the brain with dopamine-modulating therapies, thereby increasing striatal dopamine levels and improving motor impairment associated with the disease. However, this treatment has significant long-term limitations and side effects. 

"We are in desperate need of a better way of helping people with PD. It is on the increase worldwide. There is still no cure, and medications only go part way to fully treat in coordination and movement problems," said a Dr.

Recent strides in stem cell technology mean that quality, consistency, activity, and safety can be assured and that it is possible to grow essentially unlimited amounts of dopamine-producing nerve cells in the laboratory for transplantation, said a study.

"We are moving into a very exciting era for stem cell therapy. The first-generation cells are now being trialed and new advances in stem cell biology and genetic engineering promise even better cells and therapies in the future," said a researcher.

"There is a long road ahead in demonstrating how well stem cell-based reparative therapies will work, and much to understand about what, where, and how to deliver the cells, and to whom," she said.
 

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Eating Without Gaining Weight Might Now Be Possible!

There will be many like me, foodies, who love to eat their heart's content and still not gain a pound. Some may say, wishful thinking, why not? as soon, it may happen, thanks to genetic studies that are happening all over the world. Soon, we’ll be able to find out. Researchers  have identified a gene called RCANI, the inhibition of which could allow a person to eat as much as they want without getting fat.

The research reports, was based on the understanding that increasing non‐shivering thermogenesis (NST), which expends calories as heat rather than storing them as fat, is a well-championed way to combat obesity and metabolic disease. However, certain innate mechanisms constrain the capacity for NST. Regulator of Calcineurin 1 (RCAN1), one such gene, suppresses two distinctly different mechanisms of non‐shivering thermogenesis (NST).

After conducting the study on mice, the researchers found: Mice deficient for RCAN1 have an elevated metabolic rate and are resistant to diet‐induced obesity.

It is hoped that inhibiting this gene in humans could lead to similar results and help tackle obesity.
As reported , a Prof. who led the study explained that they looked at a variety of different diets with various time spans from eight weeks to almost six months, and observed health improvements in all cases where there was an absence of the RCAN1 gene.

We know a lot of people struggle to lose weight or even control their weight for a number of different reasons. The findings in this study could mean developing a pill which would target the function of RCAN1 and may result in weight loss.

Inhibiting the gene could convert white fat to healthier brown fat in humans, eradicating many health problems in them.

"In light of our results, the drugs we are developing to target RCAN1 would burn more calories while people are resting. It means the body would store less fat without the need for a person to reduce food consumption or exercise more," the Prof. added.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                                                                                                                                                                                                                        PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                                             FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                                                                                             https:// kneereplacement-stickclub.blogspot.com/                                                                                       FOR CROCHET DESIGNS                                                                                                                                                                                                                                 https://gscrochetdesigns.blogspot.com