Retinopathy of prematurity (ROP) is one of the most common serious
eye complications that occur in premature babies. It can lead to
incomplete blood vessel growth in the retina, and eventual loss of
vision. A group of researchers have identified a biomarker
that can help detect the risk of ROP from just a teardrop.
Premature babies are administered oxygen to help them survive in
incubators. This process, however, has to be monitored carefully as
overexposure to oxygen can be highly toxic to blood vessels, including
those in the retina. Overexposure to oxygen in neonatal care is a major
cause of ROP.
Low oxygen levels in the retina when the child is out of incubator
cause abnormal blood vessel growth in the retina, which in turn causes
loss of neurons and vision loss. About 40 to 50 per cent of premature
infants develop ROP, and of them 10 to 18 per cent progress to develop
severe stages of this disease leading to blindness.
Researchers who have been working on
genetic or protein-based markers for ROP for many years, have identified
a few proteins that cause inflammation in the eye leading to abnormal
blood vessel growth.
The levels of these inflammatory proteins—Complement component C3 and
Matrix metalloproteinases 2 & 9—were found to be higher in tear
samples of preterm babies with ROP. Based on these findings, the group
is developing a diagnostic test for ROP.
Researchers have also explained the role of inflammation caused by
reduced oxygen levels in the eyes in the development of this condition.
During the last few years, a screening programme for ROP was conducted
at all major neonatal intensive care units.
“While several risk factors for ROP such as low gestational age, low
birth weight, oxygen supplementation, sepsis, multiple births and
maternal health during pregnancy were thought to help in predicting the
risk of ROP progression in premature infants, but these factors can’t
help in predicting the risk of severe ROP,” says , a
scientist.
“Besides identification of biomarker for this condition, our team is
also working to fill the gap in existing knowledge about underlying
molecular pathology of ROP”.
ROP is a ‘self limiting’ condition and it disappears by itself in
most premature babies while progressing to severe stage in some.
Therefore, early diagnosis can help identify those at risk. Vision loss
in such babies can be prevented through early interventions like laser
surgery or drug-based treatments likely to become available in future.
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Labels: biomarker, blinding condition, incomplete blood vessel growth, loss of neurons, neonatal care, overexposure, oxygen, premature babies, retina, retinopathy of prematurity(ROP), teardrop, test, vision loss