Sunday, April 22, 2018

Prostate cancer breakthrough -a new accurate non-invasive test

Some scientists have made a breakthrough in prostate cancer research with a new test that could make spotting the killer disease much easier.

Prostate cancer is the most common among men with one in eight developing the condition at some point in their lives.

Current methods of detecting the illness can prove problematic, but researchers have found a new ultrasound that is less invasive, more accurate and far cheaper.

Cancerous tissue feels harder than normal so an ultrasound is far better equipped to pick it up.

So far 200 people have taken part in the study, but experts want to roll it out further to help save more lives across various places every year.

The team leader for the project, told : 'We have been able to show a stark difference in results between our technology and existing techniques such as MRI.

'The technique has picked up cancers which MRI did not reveal. 

We can now see with much greater accuracy what tissue is cancerous, where it is and what level of treatment it needs. This is a significant step forward.' 

At the moment there is no single test to detect prostate cancer. A combination of MRI scans, biopsies and physical examinations are carried out to help determine if there are higher levels of prostate-specific antigen (PSA) in the blood.

But there is currently no prostate cancer screening programme as PSA tests are often found to be unreliable. This makes the discovery could be a real game changer.

There are 47,000 new cases of the disease in every year and one man dies every 45 minutes as a result of it. 

The new technology used, known as shear wave elastrography (SWE), could help reduce prostate cancer-related fatality rates across the world. 

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Friday, May 05, 2017

First synthetic retina created for the visually impaired

The first synthetic, soft tissue retina developed by Oxford University researchers could offer fresh hope to visually impaired people. Until now, artificial retinas have only been made from hard, rigid materials. The new research is the first to successfully use biological, synthetic tissues, developed in a laboratory environment.

The study could revolutionise the bionic implant industry and the development of new, less invasive technologies that more closely resemble human body tissues, helping to treat degenerative eye conditions such as retinitis pigmentosa. Just as photography depends on camera pixels reacting to light, vision relies on the retina performing the same function.

The retina sits at the back of the human eye, and contains protein cells that convert light into electrical signals that travel through the nervous system, triggering a response from the brain, ultimately building a picture of the scene being viewed.

Vanessa Restrepo-Schild led the team at Oxford University in the UK which developed the synthetic, double layered retina which closely mimics the natural human retinal process. The retina replica consists of soft water droplets (hydrogels) and biological cell membrane proteins. Designed like a camera, the cells act as pixels, detecting and reacting to light to create a grey scale image.

“The synthetic material can generate electrical signals, which stimulate the neurons at the back of our eye just like the original retina,” said Restrepo-Schild.The study, published in the journal Scientific Reports, shows that unlike existing artificial retinal implants, the cell-cultures are created from natural, biodegradable materials and do not contain foreign bodies or living entities.

The implant is less invasive than a mechanical devise, and is less likely to have an adverse reaction on the body.”The human eye is incredibly sensitive, which is why foreign bodies like metal retinal implants can be so damaging, leading to inflammation and/or scarring. “But a biological synthetic implant is soft and water based, so much more friendly to the eye environment,” Restrepo-Schild added.

 At present the synthetic retina has only been tested in laboratory conditions, and researchers want to explore potential uses with living tissues. The next step is vital in demonstrating how the material performs as a bionic implant, researchers said. They have filed a patent for the technology and the next phase of the work will see the Oxford team expand the replica’s function to include recognising different colours. Working with a much larger replica, the team will test the material’s ability to recognise different colours and potentially even shapes and symbols. Further research will expand to include animal testing and then a series of clinical trials in humans.

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Friday, March 18, 2016

Newly-developed spongy polymer can help repair spine

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  A team of researchers has come up with a new treatment to repair the damaged spines using a biodegradable spongy polymer.

When surgically placed in the damaged vertebrae, the polymer graft grows up to be just the right size and shape to fix the spinal column.

Researcher Lichun Lu from Mayo Clinic said that the overall goal of this research is to find ways to treat people with metastatic spinal tumors. The spine is the most common site of skeletal metastases in cancer patients, but unlike current treatments, their approach is less invasive and is inexpensive.


To develop it, Lu and her postdoctoral fellow, Xifeng Liu, sought a material that could be dehydrated down to a size compatible with posterior spinal surgery, and then, once implanted, absorb fluids from the body, expanding to replace the missing vertebrae.

This information is key for determining the optimal size of a spinal implant for use in restorative surgery. The team identified a combination of materials that are bio-compatible in animals and that they believe will work in humans.

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Sunday, April 06, 2014

New heart valve does not require open surgery

Doctors in the US have implanted a newly approved aortic heart valve device in a patient that does not require open surgery.

The device, approved by the Food and Drug Administration (FDA), is called the Medtronic CoreValve System.

On March 28, Loyola University Medical Centre became the first Illinois hospital to implant the device in a patient who was not part of a clinical trial.

The new device is deployed with a catheter, which is inserted in an artery in the groin and guided up to the heart.

Once in place, the artificial valve takes over the function of a diseased valve. The system is much less invasive than traditional open-heart surgery.

Loyola physicians also have implanted the device in patients participating in clinical trials, including a landmark trial.

The study found that patients who received the device had significantly lower mortality than heart valve patients who underwent open-heart surgery.

"This is a major breakthrough," said Fred Leya, co-principal investigator at the Loyola site, along with Mamdouh Bakhos.

The study, published in the New England Journal of Medicine, included 795 seriously ill heart-valve patients who were randomly assigned to receive the new device or to undergo open-heart surgery.

After one year, the mortality rate was 19.1 per cent in the group that underwent open-heart surgery, but only 14.2 per cent in the group that received the new device.

After 30 days, quality-of-life scores improved 19 points for patients who received the new device, compared with 3.7 points for open-surgery patients.

At the one-year mark, quality-of-life scores increased 23.2 points in the device group and 21.9 points in the open-heart surgery group.

Quality of life is measured on a 100-point scale, in which 5 points is considered important and 20 points is considered a very large improvement.

Aortic stenosis occurs when the heart's aortic valve is narrowed, restricting blood flow from the heart to the body. The valve doesn't open properly, forcing the heart to work harder to pump blood.

Symptoms include fatigue, dizziness, chest pain/pressure, heart murmur, shortness of breath during activity, heart palpitations and fainting.

Aortic stenosis can lead to heart failure and death, researchers said.

The FDA approved the device in January 2014 to treat patients with severe aortic stenosis who are too ill or frail to have their aortic valves replaced through open-heart surgery.

Such patients have a nearly 50 per cent risk of death at the one-year mark unless they are treated.


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