Scientists discover new compound that could help treat ovarian cancer

A new research now finds scientists  discover a compound that could be more effective in treating a few types of cancers than standard chemotherapy.

While chemotherapy is still the first line of defense for most cancer tumours and is often highly effective, many cancers are naturally resistant, or develop resistance, to commonly used first-line chemotherapy drugs like cisplatin.

Researchers identified new drug-candidates that would work against these types of treatment resistant cancers.

In the study, scientists screened new compounds made in the lab against a “panel” of cancers that were sensitive and resistant to standard cancer therapy. They further tested the compounds with non-malignant cells to see how toxic they were to normal cells.

They found two lead compounds that had low toxicity to non-malignant cells but were highly active against cancer cells sensitive or resistant to standard treatment.

Speaking about it, a Prof. said, “Many cancer cells – about 20 per cent – become resistant to common treatments by learning to ignore the internal signals that tell them to undergo programmed cell death, known as apoptosis.

He further added, “We have identified a compound that kills cancer cells that avoids the need for apoptosis, and so the usual resistance mechanism doesn’t work against our compound.”

According to the Prof., the compound is as potent as common current chemotherapeutics, but crucially retains its potency against treatment-resistant cancers.

By looking at the cellular response from the cancers the researchers found the new drug lead works by two different mechanisms simultaneously, making it much more difficult for cancers to develop resistance toward them during treatment.

“We think this compound could be particularly effective against ovarian cancer,” he added.
The team used a technique called “proteomics” to determine how thousands of proteins in the cells responded to exposure to the drug lead.

Professor said, “Proteomics is a remarkably powerful approach we have  to identify how living things respond to new drug candidates. The multiple mechanisms of action of the new molecules was an unexpected and exciting result.”

Researchers now want to carry out further studies to find out if the compound can be used in combination with current treatments to improve their performance.

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Sugar supplement may be helpful for tumour, cancer treatment

According to a new study, a nutritional supplement called Mannose sugar can help slow down tumour  growth and enhance the effects of chemotherpay with multiple types of cancer.

The results of the study is a step towards understanding how mannose could be used to treat cancer.

Tumours use more glucose than normal, healthy tissues. However, it is very hard to control the amount of glucose in your body through diet alone. In this study, the researchers found that mannose can interfere with glucose to reduce how much sugar cancer cells can use.

"Tumours need a lot of glucose to grow, so limiting the amount they can use should slow cancer progression. The problem is that normal tissues need glucose as well, so we can't completely remove it from the body. In our study, we found a dosage of mannose that could block enough glucose to slow tumour growth in mice, but not so much that normal tissues were affected," said lead study author.

"This is early research, but it is hoped that finding this perfect balance means that, in the future, mannose could be given to cancer patients to enhance chemotherapy without damaging their overall health," he further added.

The researchers first examined how mice with pancreatic, lung or skin cancer responded when mannose was added to their drinking water and given as an oral treatment. They found that adding the supplement significantly slowed the growth of tumours and did not cause any obvious side effects.

To test how mannose could also affect cancer treatment, mice were treated with cisplatin and doxorubicin - two of the most widely used chemotherapy drugs. They found that mannose enhanced the effects of chemotherapy, slowing tumour growth, reducing the size of tumours and even increasing the lifespan of some mice.

Several other cancer types, including leukemia, osteosarcoma, ovarian and bowel cancer, were also investigated. Researchers grew cancer cells in the lab and then treated them with mannose to see whether their growth was affected.

Some cells responded well to the treatment, while others did not. It was also found that the presence of an enzyme that breaks down mannose in cells was a good indicator of how effective treatment was.

"Our next step is investigating why treatment only works in some cells so that we can work out which patients might benefit the most from this approach. We hope to start clinical trials with mannose in people as soon as possible to determine its true potential as a new cancer therapy," said a researcher.

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This natural sugar supplement could help fight cancer

Mannose-- a nutritional supplement -- found naturally in fruits such as cranberries can aid in slowing the growth of tumours and improve cancer treatment, a study has shown.

The findings showed that mannose enhanced the effects of chemotherapy in mice with multiple types of cancer including leukaemia, osteosarcoma, ovarian and bowel cancer. It slowed tumor growth, reduced the size of tumours and even helped increase the lifespan of some mice.

Tumours use more glucose than normal, healthy tissues. However, it is very hard to control the amount of glucose in your body through diet alone. Researchers found that mannose can interfere with glucose to reduce how much sugar cancer cells can use.

"Tumours need a lot of glucose to grow, so limiting the amount they can use should slow cancer progression. The problem is that normal tissues need glucose as well, so we can't completely remove it from the body. 

"In our study, we found a dosage of mannose that could block enough glucose to slow tumour growth in mice, but not so much that normal tissues were affected," said the lead author of the study.
 
"This is early research, but it is hoped that finding this perfect balance means that, in the future, mannose could be given to cancer patients to enhance chemotherapy without damaging their overall health," he added.

For the study, the team first examined how mice with pancreatic, lung or skin cancer responded when mannose was added to their drinking water and given as an oral treatment. They found that adding the supplement significantly slowed the growth of tumours and did not cause any obvious side effects.

To test how mannose could also affect cancer treatment, mice were treated with cisplatin and doxorubicin -- two of the most widely used chemotherapy drugs. 

Some cells responded well to the treatment while others did not. It was also found that the presence of an enzyme that breaks down mannose in cells was a good indicator of how effective treatment was.



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Vitamin E helps control neuropathy after chemotherapy treatments

800 mg of Vitamin per day has been shown to prevent chemotherapy-induced neuropathy brought on my Cisplatin and other Platin drugs, an average of 74 % of the time.

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