Gut microbiota linked to organ damage in patients with sepsis
Gut microbiota linked to organ damage in patients with sepsis finds a new study.
Sepsis is a serious condition that can result in organ failure and even death. A novel human study demonstrates for the 1st time that the gut microbiota of patients with sepsis plays a major role in organ damage.
Sepsis is a potentially life-threatening condition caused by the body's response to an infection. The body normally releases chemicals into the bloodstream to fight infection. Sepsis occurs when the body's response to these chemicals is out of balance, triggering changes that can damage multiple organ systems.
To conduct the experiment, researchers 1st compared the fecal microbial composition of 2 human groups- people who had sepsis and those who did not. They observed that the gut microbiota was altered at both functional and compositional levels in the 1st group, compared with that of the 2nd group.
The researchers then translated the feces to recipient mice, induced sepsiss in the mice, and checked the mice's organ injuries. The mice transplanted with feces from the 1st group showed more severe liver damage than the mice transplanted with feces from the 2nd group, even though all the mice had been induces with sepsis. These initial findings suggest that targeting intestinal microbiota may help people recover from sepsis.
Keeping healthy microbiota in your gut is important to maintain normal immune status and com batting diseases like sepsis, said a Prof. of pathophysiology. With further study, transplantation of healthy feces may one day serve as a novel approach for treating sepsis in intensive care units.
The microbiome is one of the most penetrating fields in the modern era of human homeostasis and pathology and this study is yet one more exciting dimension, said a researcher.
Sepsis is a serious condition that can result in organ failure and even death. A novel human study demonstrates for the 1st time that the gut microbiota of patients with sepsis plays a major role in organ damage.
Sepsis is a potentially life-threatening condition caused by the body's response to an infection. The body normally releases chemicals into the bloodstream to fight infection. Sepsis occurs when the body's response to these chemicals is out of balance, triggering changes that can damage multiple organ systems.
To conduct the experiment, researchers 1st compared the fecal microbial composition of 2 human groups- people who had sepsis and those who did not. They observed that the gut microbiota was altered at both functional and compositional levels in the 1st group, compared with that of the 2nd group.
The researchers then translated the feces to recipient mice, induced sepsiss in the mice, and checked the mice's organ injuries. The mice transplanted with feces from the 1st group showed more severe liver damage than the mice transplanted with feces from the 2nd group, even though all the mice had been induces with sepsis. These initial findings suggest that targeting intestinal microbiota may help people recover from sepsis.
Keeping healthy microbiota in your gut is important to maintain normal immune status and com batting diseases like sepsis, said a Prof. of pathophysiology. With further study, transplantation of healthy feces may one day serve as a novel approach for treating sepsis in intensive care units.
The microbiome is one of the most penetrating fields in the modern era of human homeostasis and pathology and this study is yet one more exciting dimension, said a researcher.