Novel therapy promises prostate cancer treatment

A new gene therapy could have the potential to treat prostate cancer that causes 300,000 deaths worldwide each year, a new study said after it halted the majority of tumours in laboratory models. 

The 'seek-and-destroy' gene therapeutic system was used against two types of a prostate tumour and more than half of them vanished over a period of one month.

However, the therapy is currently in limited use due to lack of delivery systems that can selectively deliver the genes to the tumours without adverse side effects to healthy tissues.

The 'seek-and-destroy' nanomedicine linked to an iron-carrying protein called lactoferrin was developed and the study focused on two prostate cancer cell lines -- PC-3 and DU145.

The intravenous administration of the nanomedicine treatment resulted in the complete disappearance of 70 per cent of the PC-3 tumours and half of the DU145 prostate tumours over one month, revealed the findings published in the journal.

"Although some treatments, including chemotherapy and radiotherapy, can be effective against localised tumours, there is still no effective treatment for patients whose cancer recurs or spreads.

"This means that new therapeutic approaches are urgently needed for these patients," said a Senior Lecturer and researcher. Prostate cancer is the fourth most widespread cancer in the world.

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New therapy makes HIV virus vanish from the blood of patient

SCIENTISTS in Britain are hopeful they may have cured HIV after the virus vanished from the blood of a patient treated with a new therapy. 

According to The Sunday Times, the 44-year-old is one of 50 people currently trialing a treatment that targets the disease even in its dormant state.

The unidentified patient, a social care worker in London, said: “It would be great if a cure has happened. My last blood test was a couple of weeks ago and there is no detectable virus.”

The therapy was created by a team of scientists from five UK universities: Oxford, Cambridge, Imperial College London, University College London and King’s College London.

Scientists told the paper the virus is currently undetectable in the man’s blood and if it stays that way it will be the first complete cure.
Mark Samuels, managing director of the UK’s National Institute for Health Research Office for Clinical Research Infrastructure, told the paper: “We are exploring the real possibility of curing HIV. This is a huge challenge and it’s still early days but the progress has been remarkable.”

HIV targets the immune system, attaching itself to the DNA of T-cells, where the disease can both hide out and reproduce.

Current antiretroviral therapies (Art) target that process but cannot spot dormant infected T-cells.

The new therapy works firstly by recognising and removing the HIV-infected cells. In the next stage, a new drug called Vorinostat turns the dormant T-cells active so that they can be spotted and then targeted by the immune system.

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