Brain cancer, tumour can be triggered by healing process that follows stroke, brain injury

The human body is amazing, and even when the body only intends to do good, heal, and recover from certain health issues it is faced with, sometimes the healing processes can backfire. One such incidence is seen in auto-immune diseases, where the body's immune response can also target the healthy cells. As per the latest study, for instance, the healing process that follows a stroke, trauma, brain infection, or brain injury can trigger the development of cancer, a study has found. 

According to researchers from Canada, when they analysed cells from tumours of 26 patients with a common but aggressive form of brain cancer known as glioblastoma, it was found that mutations can derail the process which is supposed to create new cells to replace those that have been lost, and spike tumour growth. 

The team hopes that the research will help in developing more tailored therapies for individual brain cancer patients. As per researchers, the findings could lead to new therapies for glioblastoma patients, who currently have limited treatment options and an average lifespan of only 15 months after diagnosis. 

'Our data suggest that the right mutational change in particular cells in the brain could be modified by injury to give rise to a tumour,' said paper author and neurosurgeon Peter Dirks of The Hospital for Sick Children in Toronto. 

'Glioblastoma can be thought of as a wound that never stops healing,' Dr Dirks said.

'We're excited about what this tells us about how cancer originates and grows and it opens up entirely new ideas about treatment by focusing on the injury and inflammation response.'

The researchers used single-cell RNA sequencing and machine learning technologies to map out the molecular make-up of glioblastoma stem cells – the one that is responsible for tumour initiation and recurrence after treatment. 

The team found new subpopulations of glioblastoma stem cells which bear the molecular hallmarks of inflammation and are comingled with other cancer stem cells inside patients' tumours.

These findings, as per Dr Dirks, suggest that some cancer start to form when the normal tissue healing process begins, which is actually supposed to generate new cells to replace those lost to injury, gets derailed by mutations. 

This, he added, might happen many years before a patient becomes symptomatic.

Once a mutant cell becomes engaged in wound healing, it doesn't stop multiplying — with all normal controls broken — spurring tumour growth, the team said.

'The goal is to identify a drug that will kill the glioblastoma stem cells,' said paper author and molecular geneticist Gary Bader of the University of Toronto.

'But we first needed to understand the molecular nature of these cells in order to be able to target them more effectively.'

The findings of the study were published in the journal Nature Cancer. 

As the initial study is now complete, researchers are now looking to target these biases for tailored therapies. 

'We're now looking for drugs that are effective on different points of this gradient,' said paper author and cancer genomicist Trevor Pugh of the Princess Margaret Cancer Centre in Toronto.

'There's a real opportunity here for precision medicine — to dissect patients' tumours at the single-cell level and design a drug cocktail that can take out more than one cancer stem cell subclone at the same time.'

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Honey - 4 Reasons Why You Should Start Eating It Today

Traditionally, the use of honey stretches back to time immemorial. It is still considered one of the most precious gifts of nature to mankind. Modern research also suggests that honey has unique medicinal and nutritional properties. Honey should be incorporated in your daily diet as it is one food which is naturally beneficial for your overall health and does have any side effects.

Following are the traditional uses of honey, according to ayurveda:

1. Prevents anemia: Honey contains high amounts of iron, manganese and copper which are very essential for building haemoglobin. According to ancient texts, honey is a traditional cure as well as prevention for anemia as it helps in maintaining the optimum level of red blood corpuscles and haemoglobin.

2. Promotes eye health: Honey has been used to treat various eye diseases since ancient times. It is known to improve vision with daily application. It is an effective cure against diseases like  conjunctivitis, trachoma or even something as minor as eye itching. It is also beneficial to treat glaucoma in the early stages. 

3. Skin care: Ancient texts on ayurveda mention that external application of honey is effective in curing sores or other wounds. It works like an antiseptic and helps to soothe pain and hastens the healing process. It is also used to treat skin burns or carbuncles.

4. Cure for coughs: Honey is extremely useful in treating coughs. It works as a demulcent which aids in soothing the swollen mucous membrane present on the upper respiratory tract. It relieves you from irritating coughs and associated symptoms like frequent spurts of cough while talking and difficulty in swallowing. It is a chief ingredient in ayurvedic cough syrups for the same reason. You can also try honey gargles to relieve pain from throat inflammation. 

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Anti-inflammatory diet: How is it good for your overall health

Inflammation is a necessary part of the healing process. Our body uses inflammation to fight illness and protects us from further harm. However, some medical conditions can cause faulty inflammation response, which are called chronic inflammatory diseases. 

The best thing that one can do to reduce and prevent inflammation is to opt for an anti-inflammation diet. The anti-inflammation diet includes eating certain foods and avoiding some.

How an anti-inflammatory diet works
The anti-inflammatory diet increases the amount of antioxidants that reduce the free radicals in the body. Free radicals can damage body cells and increase the risk of certain diseases.
Conditions that can be improved by having an anti-inflammatory diet
Doctors recommend having the anti-inflammatory diet as a complementary treatment for conditions that can be worsened by chronic inflammation. Some of the conditions that can be improved by having an anti-inflammatory diet include rheumatoid arthritis, psoriasis, asthma, Crohn’s disease, colitis, inflammatory bowel disease, diabetes, obesity, heart disease, lupus, metabolic syndrome and Hashimoto’s disease.
Foods to eat during the anti-inflammatory diet
Dark leafy vegetables, blueberries, blackberries, cherries, dark red grapes, broccoli, cauliflowers, beans, lentils, green tea, red wine (in moderation), avocado, olives, coconut, extra virgin olive oil, walnuts, almonds, pine nuts, pistachios, turmeric, cinnamon, dark chocolate and cold-water fish including salmon and sardines.
Foods to avoid during the anti-inflammatory diet
Anti-inflammatory diet does not just mean eating more of some specific foods but also avoiding some particular foods.
The list includes processed meats, sugary drinks, fried foods, white bread, white pasta, vegetable oil, soybean oil, gluten. Processed snacks like chips, excess alcohol and too many carbohydrates should be avoided too.
Vegetarian food and inflammation
Studies suggest that people who follow a vegetarian diet have high levels of plasma AA, which is a marker of overall health and is linked with lower levels of inflammation and heart disease.
Another 2017 study suggests that animal products increase the risk of systemic inflammation. While another study suggests that reduced inflammation is one of the key benefits of began diet.
Verdict
Anti-inflammatory diet reduces inflammation. By following the diet, people can reduce their body’s inflammation responses. Reduced inflammation can help people avoid some potential health problems caused by chronic inflammation. 

 

this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   
https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement