Sleep disorders might now be treated with AI

Artificial intelligence can improve the precision of sleep medicines, resulting in more patient-centered care and better outcomes, suggest a new study.

The position statement of the study was published in the journal - Journal of Clinical Sleep Medicine.

The position statement was developed by the AASM's Artificial Intelligence in Sleep Medicine Committee.

According to the statement, the electrophysiological data collected during polysomnography -- the most comprehensive type of sleep study -- is well-positioned for enhanced analysis through AI and machine-assisted learning.

"When we typically think of AI in sleep medicine, the obvious use case is for the scoring of sleep and associated events," said the lead researcher Dr Cathy Goldstein.

"This would streamline the processes of sleep laboratories and free up sleep technologist time for direct patient care," she added.

Because of the vast amounts of data collected by sleep centres, AI and machine learning could advance sleep care, resulting in more accurate diagnoses, prediction of disease and treatment prognosis, characterization of disease subtypes, precision in sleep scoring, and optimization and personalization of sleep treatments.

Goldstein noted that AI could be used to automate sleep scoring while identifying additional insights from sleep data.

"AI could allow us to derive more meaningful information from sleep studies, given that our current summary metrics, for example, the apnea-hypopnea index, aren't predictive of the health and quality of life outcomes that are important to patients," Dr Cathy Goldstein said.

"Additionally, AI might help us understand mechanisms underlying obstructive sleep apnea, so we can select the right treatment for the right patient at the right time, as opposed to one-size-fits-all or trial and error approaches," she added.

Important considerations for the integration of AI into the sleep medicine practice include transparency and disclosure, testing on novel data, and laboratory integration.

The statement recommends that manufacturers disclose the intended population and goal of any program used in the evaluation of patients; test programs intended for clinical use on independent data; and aid sleep centres in the evaluation of AI-based software performance.

"AI tools hold great promise for medicine in general, but there has also been a great deal of hype, exaggerated claims and misinformation," said Goldstein.

"We want to interface with industry in a way that will foster safe and efficacious use of AI software to benefit our patients. These tools can only benefit patients if used with careful oversight," Goldstein added.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement 

Study shows feasibility of using a robot to treat brain aneurysms

Using a robot to treat brain aneurysms is feasible and could allow for improved precision when placing stents, coils and other devices, according to late breaking science presented today at the American Stroke Association's International Stroke Conference 2020. The conference, Feb. 19-21 in Los Angeles, is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health.

Robotic technology is used in surgery and cardiology, but not for brain vascular procedures. In this study, Canadian researchers report the results of the first robotic brain vascular procedures. They used a robotic system specifically adapted for neurovascular procedures. Software and hardware adaptations enable it to accommodate microcatheters, guidewires and the other devices used for endovascular procedures in the brain. These modifications also provide the operator additional precise fine-motor control compared to previous system models.

This experience is the first step towards achieving our vision of remote neurovascular procedures. The ability to robotically perform intracranial aneurysm treatment is a major step forward in neuro-endovascular intervention."     Vitor Mendes Pereira, M.D., M.Sc., lead researcher, a neurosurgeon and neuroradiologist at the Toronto Western Hospital, and professor of medical imaging and surgery at the University of Toronto in Canada

In the first case, a 64-year-old female patient presented with an unruptured aneurysm at the base of her skull. The surgical team successfully used the robot to place a stent and then, using the same microcatheter, entered the aneurysm sac and secured the aneurysm by placing various coils. All intracranial steps were performed with the robotic arm. Since this first case, the team has successfully performed five additional aneurysm treatments using the robot, which included deploying various devices such as flow-diverting stents.

"The expectation is that future robotic systems will be able to be controlled remotely. For example, I could be at my hospital and deliver therapy to a patient hundreds or even thousands of kilometers away," Mendes Pereira said. "The ability to deliver rapid care through remote robotics for time-critical procedures such as stroke could have a huge impact on improving patient outcomes and allow us to deliver cutting-edge care to patients everywhere, regardless of geography."

"Our experience, and that of future operators of this technology, will help develop the workflows and processes necessary to implement successful robotic programs, which will ultimately help establish remote care networks in the future," Mendes Pereira said.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement 

Researchers discover new methid to reduce chemo doses for patients

Chemotherapy, which is a saviour for many cancer patients, is a painful treatment to undergo following which many patients quit it midways.

But researchers, have developed a method that delivers chemotherapy drugs directly to malignant cells and bypasses healthy ones. With this discovery, doctors aim to reduce chemo doses for patients, thereby reducing the unpleasantness side-effects associated with the treatment.

Most anti-cancer treatment are not sufficiently specific, meaning they attack healthy cells together with the malignant ones they're trying to get rid of, explained a Prof.

This leads to the many serious side-effects associated with chemotherapy. Eliminating cancerous cells while leaving healthy one alone is an important step towards reducing patients'  suffering, the Prof. added.

The study focused on the selective expression of the TRPV2 protein by cancer cells. When activated, TRPV2 protein opens a canal inside cell membranes.

Researchers studied liver cancer cells and were able to successfully insert a low dose of doxorubicin, a chemotherapeutic agent, through the canal directly into cancer cells.

Not only did the new method target cancer cells without harming healthy ones. In the future, the precision of this delivery method may allow doctors to prescribe lower chemo doses and to relieve patients from some of the harsher effects of chemo.

It's too early to make concrete predictions but we are hopeful this discovery will lead the way towards a new, more targeted delivery method for chemotherapy treatment, one that will drastically reduce patients' pain, the Prof. concluded.

this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     
https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement     

Precision cancer therapy effective in both children and adults

Three quarters of patients, both adults and children, with a variety of advanced cancers occurring in different sites of the body responded to larotrectinib, a novel therapy that targets a specific genetic mutation. Results of this multisite phase 1/2 trial have been published in the journal on February 22, 2018. Unlike most cancer therapies, this oral treatment is based on the genetic traits of the tumor and not the organ where the cancer originated. 
 
An acquired genetic defect, TRK fusions accelerate cancer cell growth. Larotrectinib is highly selective for inhibiting this process. Fifty-five patients, ranging from 4 months to 76 years of age, with 17 unique tumor types, were treated with larotrectinib. Three quarters of patients enrolled responded to therapy and 86% of responding patients remain on study or have undergone curative surgery. No patients discontinued treatment due to drug-related side effects.

Several pediatric patients that enrolled in the study had infantile fibrosarcoma, a type of cancer that harbors a TRK fusion and is difficult to treat since it responds poorly to chemotherapy. Radiation therapy is also not a good option since it has devastating long-term effects for young patients.

"This is truly a magic bullet for our patients with TRK-positive cancer," said a researcher, who helped design the pediatric part of the study. "In some cases, this cancer can be treated surgically - often requiring amputation or another disfiguring surgical procedure. After treating our patient with infantile fibrosarcoma with larotrectinib, the cancer shrunk sufficiently and we were able to surgically remove the tumor while preserving the patient's leg."

This study is part of a noteworthy drug development program. Typically, testing of new therapies in a pediatric population is done after the drug is licensed for adults, if at all. However, larotrectinib was simultaneously studied in children and adults. A special liquid formulation was developed for administering appropriate doses to very young patients. This early pediatric focus helped to accelerate clinical development by aiding in the rapid accrual of appropriate patients.

The government granted larotrectinib breakthrough therapy designation that resulted in an expedited review. Drugs may qualify as breakthrough therapies when preliminary clinical data indicate that the new treatment offers substantial advantages over existing options for serious or life-threatening diseases. 

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.    

PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-                      
HTTP:GSEASYRECIPES.BLOGSPOT.COM/

FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                     

HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/
FOR CROCHET DESIGNS
HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM

New breakthrough to up precision and safety of radiation treatment in cancer patients

A scientific breakthrough may help give the field of radiation oncology new tools to raise the precision and safety of radiation treatment in cancer patients by helping doctors view the powerful beams of a linear accelerator while they enter or exit the body.

As a way to make radiation safer and better, Dartmouth began to investigate a scientific phenomenon called the Cherenkov effect in 2011.

As a first step, engineers at the Thayer School of Engineering at Dartmouth modified a regular camera with a night vision scope to take photos of radiation beams as they passed through water.

What appeared on the photos is the Cherenkov effect, a luminescent blue glow.

To refine the approach for use in radiation treatment, scientists used a mannequin of the human body. They measured and studied the results to refine their ability to capture the luminescence, experimenting with beam size, position, and wavelength.

With the clinical aspects refined, Geisel School of Medicine researchers photographed luminescence during the routine radiation treatment of a dog with an oral tumour.

This was the first time Cherenkov studies came out of the laboratory and into a treatment setting. The scientists coined the approach Cherenkoscopy. As they anticipated, during the session they were able to see detailed information about the treatment field and the dose.

The results have been published in the Journal of Biomedical Optics.

ps- this is only for information, always consult you physician before having any particular food/ medication/exercise/other remedies.

ps- those interested in recipes are free to view my blog-

http://gseasyrecipes.blogspot.com/

for info about knee replacement, you can view my blog-

http://Knee replacement-stick club.blogspot.com/

for crochet designs

http://My Crochet Creations.blogspot.com