A Magic Gel Could Save Amputations for Diabetics now.

 Millions of diabetics live in fear of a wound that won’t heal. One bad cut can cost a limb.

UC Riverside created a gel that delivers a continuous flow of oxygen directly into the deepest layers of injured tissue using a tiny battery-powered system. Chronic wounds spiral out of control because oxygen can’t reach where it’s needed. This gel fixes that.

No surgery. No skin grafts. Just a gel that breathes life into dying tissue.
Diabetes affects 537 million people. This could save millions of them from amputation.

Shared for informational purposes only. Source: UC Riverside / ScienceDaily (February 22, 2026)
 

 

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Drugs to Treat Type 2 Diabetes Can Lead to Heart Disease

Intake of two commonly used drugs to treat Type 2 diabetes carries a high risk of cardiovascular events such as heart attack, stroke, heart failure or amputation, warns a new study. The two drugs - sulfonylureas and basal insulin - are the second-line medication after metformin, a widely accepted initial Type-2 diabetes treatment.

The study, showed that patients who take one of these two drugs are more likely - 36 per cent more for sulfonylureas and twice as likely for basal insulin - to experience cardiovascular harm than those taking a newer class of diabetes drugs known as DPP-4 inhibitors. "People should know if the medications they are taking to treat their diabetes could lead to serious cardiovascular harm. This calls for a paradigm shift in the treatment of Type 2 diabetes," said the lead author of the study.

Physicians should consider prescribing newer classes of antidiabetic medications, such as GLP-1 agonists (liraglutide), SGLT-2 inhibitors (empagliflozin)or DPP-4 inhibitors (sitagliptin), more routinely after metformin, rather than sulfonylureas or basal insulin, suggest the researchers. These drugs, however, are more expensive than the sulfonylureas, which is the main reason they are not as commonly prescribed.


The study should force medical providers to think about cardiovascular effects of these drugs early in the course of diabetes treatment, and shift prescribing patterns to newer drugs that have more favourable cardiovascular profiles, the team said. This was an observational study using data from 132,737 patients with Type 2 diabetes who were starting second-line treatment.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                
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Researcher Invent Material To Speed Up Wound Healing in Diabetics!

If an average person were to sustain an open wound, it would take almost take 23 days to heal. But that isn’t the case for diabetics.

When a diabetic person sustains an injury, it can take almost 26 days or longer for it to heal untreated. In many cases, this can lead to chronic non-healing wounds and ultimately, complications like amputations.

And so for a long time, the treatment of such wounds has been a major challenge, not only for the diabetic persons but also their doctors. And while there are a few wound dressing alternatives available, they are not commercially viable due to costs.

But what if we told you that one unique low-cost dressing is set to change that?

Researchers in India have developed a wound-dressing using a carbon allotrope and psyllium husk (isabgol), which can help wounds in both healthy as well as diabetics persons heal almost a week earlier than usual.

The testing on rats displayed that the normal wounds treated with this dressing healed within 16 days as compared to 23 days required for untreated ones.

Similarly, diabetic wounds healed in 20 days as compared to 26 days required for untreated wounds.
Speaking to the media, one of the authors of the research paper said, “Wounds in people with diabetes heal slower than in healthy people, with the inflammation or the painful phase taking longer. This delays the formation of blood vessels and the cellular matrix, but the challenge is that we do not know why this happens.”

What does this dressing contain?

This new dressing is made using reduced graphene oxide (a thin sheet of graphite that has been reduced using intense sunlight) which is then mixed with a rubbery electrolysed isabgol. The result is a wound-healing scaffold.

The researchers also added that while the electrical properties of reduced graphene oxide are known, its active biomedical properties were not utilised in the past. And this new dressing aims to explore these biomedical properties.

“The material we have developed improves the blood vessel formation and helps in healing wounds faster,” the Prof. said.

The team of researchers and scientists are now experimenting with various materials that can speed the process of healing.

While the current costs for the fast healing dressing materials are up to USD 2,000 for a four to five sq-in patch, the team is now planning to cut it down to an affordable INR 1,000.

This dressing material is used to cover the open wound directly instead of the usual cotton or gauze dressing. And can then be wrapped over using a normal bandage.

A diabetologist added that the healing time of a wound depends on various factors like the blood sugar level of the person, the location of the wound, the amount of blood circulation in the wounded area, nerve damage, or deep bone wound etc.

“However, it is extremely difficult to form blood vessels where there are none. This scaffold, in preliminary animal trials, has given promising results, but its efficacy remains to be seen in humans,” he told.

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Precision cancer therapy effective in both children and adults

Three quarters of patients, both adults and children, with a variety of advanced cancers occurring in different sites of the body responded to larotrectinib, a novel therapy that targets a specific genetic mutation. Results of this multisite phase 1/2 trial have been published in the journal on February 22, 2018. Unlike most cancer therapies, this oral treatment is based on the genetic traits of the tumor and not the organ where the cancer originated. 
 
An acquired genetic defect, TRK fusions accelerate cancer cell growth. Larotrectinib is highly selective for inhibiting this process. Fifty-five patients, ranging from 4 months to 76 years of age, with 17 unique tumor types, were treated with larotrectinib. Three quarters of patients enrolled responded to therapy and 86% of responding patients remain on study or have undergone curative surgery. No patients discontinued treatment due to drug-related side effects.

Several pediatric patients that enrolled in the study had infantile fibrosarcoma, a type of cancer that harbors a TRK fusion and is difficult to treat since it responds poorly to chemotherapy. Radiation therapy is also not a good option since it has devastating long-term effects for young patients.

"This is truly a magic bullet for our patients with TRK-positive cancer," said a researcher, who helped design the pediatric part of the study. "In some cases, this cancer can be treated surgically - often requiring amputation or another disfiguring surgical procedure. After treating our patient with infantile fibrosarcoma with larotrectinib, the cancer shrunk sufficiently and we were able to surgically remove the tumor while preserving the patient's leg."

This study is part of a noteworthy drug development program. Typically, testing of new therapies in a pediatric population is done after the drug is licensed for adults, if at all. However, larotrectinib was simultaneously studied in children and adults. A special liquid formulation was developed for administering appropriate doses to very young patients. This early pediatric focus helped to accelerate clinical development by aiding in the rapid accrual of appropriate patients.

The government granted larotrectinib breakthrough therapy designation that resulted in an expedited review. Drugs may qualify as breakthrough therapies when preliminary clinical data indicate that the new treatment offers substantial advantages over existing options for serious or life-threatening diseases. 

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Foot care for diabetics

It’s important to understand why diabetes and foot care is inter-related. Diabetes reduces the blood flow to the feet, it also causes nerve damage. It’s hard to notice a cut or blister if you can’t feel the pain or discomfort in your feet. Delay in spotting and treating these minor injuries can lead to bigger problems. In extreme cases, it can even lead to amputation.

• Check your feet daily: Take ten minutes from your schedule and do this religiously. Check for cuts, blisters, bruises, redness and swelling. Don’t forget to check in between the toes. Call your doctor if you notice any kind of abnormality.
• Wash your feet every day: Use warm water and a mild soap to cleanse your feet thoroughly. Avoid soaking your feet for a long time. Remember to dry your feet thoroughly, especially between the toes. Moisture between the toes is an invitation for fungal infections.
• Wear comfortable shoes: Apart from the fit, check the material of the shoe. Ensure it does not pinch or rub your skin. Shoe bites and diabetes should stay miles away from each other. Protect your feet from the elements. Prefer to use covered shoes with clean socks.

    Not sure if you are wearing the right shoes? Here is a simple test to help you!

Stand on a piece of paper and trace the outline of your foot.
Next trace the outline of your foot.
Compare the two. Ideally, the shoe should be as broad as your foot and should be half an inch longer.

• Keep your toenails trimmed: Cut your nails straight. Don’t try to round the edges or cut the sides, it may lead to ingrown toenails. Avoid getting a pedicure at a salon as the instruments may not be sterilized and a small cut or bruise could lead to an infection.

• Moisturise your feet: To keep cracked heels at bay, it’s necessary to keep your feet moisturised. But ensure that your feet are not damn or sticky afterwards. Avoid moisturising the region between your toes.
• Treating minor corns or calluses: Even though they seem really minor, if they get infected, even the smallest of corns or calluses can cause a world of trouble. Stay safe, call your healthcare advisors and get them to take a look at it.
• Situations in which you MUST reach out to your doctor: If your feet are cold or they hurt, or if they have changed colour to a shade of black and blue, pick up the phone and call your doctor.