Drugs to Treat Type 2 Diabetes Can Lead to Heart Disease
Intake of two commonly used drugs to treat Type 2 diabetes carries a
high risk of cardiovascular events such as heart attack, stroke, heart
failure or amputation, warns a new study. The two drugs - sulfonylureas
and basal insulin - are the second-line medication after metformin, a
widely accepted initial Type-2 diabetes treatment.
The study, showed that patients who take one of these two drugs are more likely - 36 per cent more for sulfonylureas and twice as likely for basal insulin - to experience cardiovascular harm than those taking a newer class of diabetes drugs known as DPP-4 inhibitors. "People should know if the medications they are taking to treat their diabetes could lead to serious cardiovascular harm. This calls for a paradigm shift in the treatment of Type 2 diabetes," said the lead author of the study.
Physicians should consider prescribing newer classes of antidiabetic medications, such as GLP-1 agonists (liraglutide), SGLT-2 inhibitors (empagliflozin)or DPP-4 inhibitors (sitagliptin), more routinely after metformin, rather than sulfonylureas or basal insulin, suggest the researchers. These drugs, however, are more expensive than the sulfonylureas, which is the main reason they are not as commonly prescribed.
The study should force medical providers to think about cardiovascular effects of these drugs early in the course of diabetes treatment, and shift prescribing patterns to newer drugs that have more favourable cardiovascular profiles, the team said. This was an observational study using data from 132,737 patients with Type 2 diabetes who were starting second-line treatment.
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The study, showed that patients who take one of these two drugs are more likely - 36 per cent more for sulfonylureas and twice as likely for basal insulin - to experience cardiovascular harm than those taking a newer class of diabetes drugs known as DPP-4 inhibitors. "People should know if the medications they are taking to treat their diabetes could lead to serious cardiovascular harm. This calls for a paradigm shift in the treatment of Type 2 diabetes," said the lead author of the study.
Physicians should consider prescribing newer classes of antidiabetic medications, such as GLP-1 agonists (liraglutide), SGLT-2 inhibitors (empagliflozin)or DPP-4 inhibitors (sitagliptin), more routinely after metformin, rather than sulfonylureas or basal insulin, suggest the researchers. These drugs, however, are more expensive than the sulfonylureas, which is the main reason they are not as commonly prescribed.
The study should force medical providers to think about cardiovascular effects of these drugs early in the course of diabetes treatment, and shift prescribing patterns to newer drugs that have more favourable cardiovascular profiles, the team said. This was an observational study using data from 132,737 patients with Type 2 diabetes who were starting second-line treatment.
THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.
PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG- https://gseasyrecipes.blogspot.com/ FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-
https:// kneereplacement-stickclub.blogspot.com/
FOR CROCHET DESIGNS https://gscrochetdesigns.blogspot.com
Labels: amputation, basal insulin. type 2 diabetes, diabetes drug, DPP-4 inhibitors, risk of heart diseases, stroke, sulfonylureas
posted by G S Iyer at 9:28 PM
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