Painless way to monitor glucose For diabetics

Researchers have designed a microneedle patch for people with diabetes to enable them to monitor their glucose levels throughout the day in a "painless" manner. Continuous monitoring is a way to safely and reliably lower blood glucose - giving the user a full picture of their glucose levels throughout the day and helping them avoid severe hypoglycemia. 

But the currently used continuous glucose monitoring systems (known as CGMS) are uncomfortable since they require a minimum 7mm needle inserted into the skin. Owing to their size, they take measurements in the fat tissue - not the most ideal location. However, the new device, developed by researchers is 50 times smaller. 

When applied to a human participant's forearm, the combination of the patch and an extremely miniaturized three-electrode enzymatic sensor was found capable of correctly and dynamically tracking blood glucose levels over time, with a delay of about 10 minutes.

"Our solution is painless to the user. We measure directly in the skin, and there are no nerve receptors that detect pain - just a fine mesh of very tiny blood vessels," said a researcher.

Unlike commercially available CGMS which measure the subcutaneous fat tissue, the new device measures within the skin less than 1mm deep, he said.

This would offer an alternative to pricking one's fingers several times a day to take a blood test and the frequency of finger prick tests could be reduced with a glucose monitoring system, he noted.
The team has successfully tested the prototype of a microneedle patch on a human participant and the completion of a system for clinical tests is now underway.
 
THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                
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Smart Bandages Edge Closer To Market

Back in 2015 I looked at an innovative new bandage from researchers at the University of California, Berkeley, which used electrical currents to detect tissue damage before it is visible to the human eye.

“We set out to create a type of bandage that could detect bedsores as they are forming, before the damage reaches the surface of the skin,” the developers said.

So, for instance, it could provide a regular monitoring service for a wound.  The researchers documented their work in a paper that was published in Nature Communications.

This was then followed a year later by the work of a UK team, who have come up with a similar product.  The bandage is capable of turning a different color when it detects the onset of infection, thus providing medics with an early warning of problems afoot.

The product, which was documented in paper published at the time, turns bright green when the gel like material within the dressing detects bacteria.

Slow progress

These are undoubtedly fascinating projects, but there appears little sign that they are coming to market any time soon.  At least that’s the impression given by a Welsh team from Swansea University, who recently told the BBC that such bandages could be on trial within 12 months.

The bandages developed by the Welsh team utilize 5G technology to monitor what’s happening in the wound, whilst also tracking the activity levels of the wearer.

“That intelligent dressing uses nano-technology to sense the state of that wound at any one specific time.  It would connect that wound to a 5G infrastructure and that infrastructure through your telephone will also know things about you - where you are, how active you are at any one time,” the team tell the BBC.

Smart materials

The project is part of a growing number that are attempting to make materials smarter, especially in healthcare.  For instance,
researchers have also developed a smart patch that aims to help diabetes sufferers manage their insulin levels.  The patch is designed to monitor blood glucose levels and gradually release insulin if levels are too high.

The device was put through its paces in a recent study on mice.  The patch aims to take away the burden of managing insulin levels for people with either Type 1 or Type 2 diabetes by making the process both simple and injection free.

The patch is covered in micro-needles loaded with tiny, insulin-carrying pouches that are capable of painlessly injecting the wearer.  Each pouch is designed to break apart swiftly and then release the insulin as glucose levels rise.

Or you’ve got the team from Cardiff University, who are developing a smart patch to help detect the early onset of osteoarthritis in our knees.

The patch utilizes the same technology used to detect damage in the wings of an aircraft.  The technology listens out for subsonic cracking sounds in joints, which are an early indicator of later problems.

The patch promises to provide a cheaper, quicker way of diagnosis than existing methods.

“The idea has got huge potential to change the way we diagnose osteoarthritis (OA),” the team say.  “If we’re able to link the sound signature of a healthy knee and a knee with disease, we will be able to lower the costs on society a lot.”

Such devices are clearly a little way from the market, but the potential is clear for all to say, and hopefully we’re seeing signs that they are edging closer and closer.

this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.  
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Microneedle patch set to replace standard TB skin test

This test is painless and easier to administer than the traditional skin 

test with a hypodermic needle.

A team of researchers has developed a patch with tiny, biodegradable needles that are
able to penetrate  the skin and precisely deliver a TB test.

Senior author , said that with a microneedle test there’s little room for user error, because
the depth of delivery is determined by the microneedle length rather than the needle-
insertion angle. He said that this  test is painless and easier to administer than the
traditional skin test with a hypodermic needle

Researchers say that their test is going to be easier to use, less painful and has the
potential to be more successful than the standard TB skin test.

The researchers tested the patch on guinea pigs and found that after the microneedles
were inserted using the patch, the skin reaction associated with having a tuberculosis
infection was the same as when using the standard hypodermic needle test.

He said that a microneedle patch test has potential as a simpler, more reliable option than
the traditional tuberculosis test for children who are needle-shy, or in developing countries where medical care is limited.

He added that it’s like putting on a bandage, as long as the patch is applied on the skin,
the test is always delivered to the same depth underneath the skin.

ps- this is only for information, always consult you physician before having any particular food/ medication/exercise/other remedies.

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Hormone replacement therapy can cause cancer

Hormone replacement therapy that is commonly used to relieve some symptoms & used as pill, patch or vaginal ring, may involve a combination of hormones= estrogen & progesterone or only estrogen. According to a report, the daily use of HRT may risk breast cancer by 5-6 % for each year taken. if one takes just estrogen only HRT, then it quintuples risk of uterine cancer. So, doctors advise women to use HRT for shortest possible time.