Monday, November 10, 2025

Cocoa Protects Your Heart

Most of us spend long hours each day sitting—at our desks, in our cars, or on the couch at the end of the day. It's no secret that this is one of the most dangerous habits of the modern era, with potential harm to a range of vital body systems.

Prolonged sitting damages blood circulation, increases the risk of heart disease, obesity, and depression. Surprisingly, studies show that even physical fitness doesn't always compensate for this damage. 
 
Now for the good news: researchers from the University of Birmingham have found that a hot drink containing natural cocoa may prevent the damage to blood vessels caused by hours of continuous sitting. In other words, one cup of cocoa might protect your body more effectively than even physical exercise.


Strong Protection Even for People Who Don't Exercise 
The study, published in The Journal of Physiology, examined 40 young, healthy men between the ages of 18 and 34—some of whom exercised regularly and others who didn't at all. Each participant came to the laboratory for two sessions: in the first, they drank cocoa rich in flavanols, plant compounds with antioxidant properties found in natural cocoa powder, and in the second session, they drank regular cocoa containing little of this active ingredient.

The participants were then asked to sit without moving for two hours while researchers measured their blood vessel function using ultrasound. The findings showed unequivocally that while drinking regular cocoa led to a significant decline in blood vessel function in the arms and legs, drinking natural, flavanol-rich cocoa completely prevented this decline. Blood flow remained normal, even after two hours of sitting. 
 
Additionally, it's interesting to note that the participants' fitness level didn't change the outcome. Even men who exercised regularly experienced reduced blood flow when they drank regular cocoa and full protection when they drank the flavanol-rich beverage, just like the other subjects.

The Unique Compound That Protects the Heart  
The researchers explain that the flavanols in cocoa promote the production of a molecule called nitric oxide, which is responsible for dilating blood vessels and maintaining their flexibility. When we sit for long hours, blood flow slows down and nitric oxide levels drop, making it harder for blood vessels to expand and eventually damaging heart health.

Dr. Catarina Rendeiro, a nutrition scientist from the University of Birmingham who led the study, wrote in the article that "our body may be at rest when we're sitting, but our blood vessels are under constant stress. Therefore, finding simple ways to reduce this damage can help prevent cardiovascular disease." 
 
This study joins a series of findings from recent years demonstrating the benefits of natural flavanols—the same components found not only in cocoa but also in green tea, apples, grapes, and even red wine. These are compounds that improve blood vessel function, reduce blood pressure, and contribute to heart health. 
 
However, it's important to remember that this isn't justification for drinking sugar-laden chocolate milk or commercial cocoa with artificial ingredients. The researchers emphasize that the significant effect was measured only in natural cocoa drinks containing a high concentration of flavanols. To enjoy these benefits, look for a drink with at least 70% cocoa, or natural powder without sugar.

How Dangerous Is Prolonged Sitting, Really?  
According to data collected over the past decade, the average person spends more than six hours a day sitting. Studies have shown that after just two hours of inactivity, blood vessels in the legs begin to lose their flexibility. The even more concerning finding is that even people who exercise regularly suffer from this effect—meaning one evening workout doesn't necessarily cancel out the damage from an entire day spent sitting.

Researchers estimate that consuming flavanols before prolonged sitting can reduce these negative effects, especially when combined with simple habits like getting up every half hour, stretching your legs, or taking walking breaks. And of course, maintaining physical fitness at least at a basic level is still the most important tool for improving health across all metrics. 
 
cocoa 
 
Practical Tips for Implementing These Findings 
 
While the research is promising, experts recommend a multifaceted approach to combat the dangers of prolonged sitting: 
 
Choose Your Cocoa Wisely -   
Not all cocoa products are created equal. To get the protective benefits shown in the study: 
 
Opt for high-quality dark chocolate with at least 70% cocoa content 
 
 Use unsweetened natural cocoa powder when making hot drinks 
 
Avoid commercial hot chocolate mixes that are loaded with sugar and contain minimal actual cocoa 
 
 Check labels for flavanol content when available—some specialty brands now list this information 

Combine Cocoa with Movement 
The researchers stress that cocoa isn't a magic bullet that allows you to sit indefinitely without consequences. The best approach combines flavanol-rich foods with regular movement: 
 
Set hourly reminders to stand up and move around 
 
Take short walking breaks every 30-60 minutes 
 
Perform simple stretches at your desk 
 
Consider a standing desk or alternating between sitting and standing throughout the day 
 
Walk during phone calls when possible 
 
Other Flavanol-Rich Foods to Include 
 
Beyond cocoa, you can boost your flavanol intake through various foods:
 
Green tea - contains catechins, a type of flavanol 
 
Berries - especially blueberries and strawberries 
 
Apples - particularly with the skin on 
 
Red grapes - the source of flavanols in red wine 
 
Nuts - especially almonds and hazelnuts

The Bigger Picture: Sedentary Lifestyle Risks 
This research highlights a broader public health concern. The World Health Organization has identified physical inactivity as the fourth leading risk factor for global mortality. Beyond cardiovascular issues, prolonged sitting is associated with: 
 
Metabolic syndrome - including increased blood sugar and cholesterol levels 
 
Musculoskeletal problems - particularly back and neck pain 
 
Mental health issues - including increased risk of anxiety and depression 
 
Reduced life expectancy - even among those who exercise regularly 
 
A Simple Addition to Your Daily Routine 
What makes this research particularly exciting is its simplicity. Unlike many health interventions that require significant lifestyle changes, adding a cup of high-quality cocoa to your morning routine is relatively easy and enjoyable. 
 
The study's lead researcher emphasizes that this is especially relevant for office workers, students, drivers, and anyone else whose occupation requires long periods of sitting. A morning cup of flavanol-rich cocoa could provide protection throughout the workday, though the researchers are still investigating exactly how long the protective effects last.


Looking Forward while we wait for more research, there's little downside to incorporating natural, high-quality cocoa into your daily routine—especially if you spend significant time sitting. Just remember to choose products with high cocoa content and minimal added sugar, and don't let a cup of cocoa replace the fundamental need for regular movement throughout your day.


This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   


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Friday, August 09, 2019

How Sunlight Affects Your Mental Health

One factor that has an impact on mental health is sunlight. That’s the conclusion of a recent study which looked at the links between weather and depression.  Mental health data from more than 16,000 Brigham Young University students was used whereby assessments had been filled out several times by each person over the course of six years. The assessments were then matched to local weather data. 
 
Within the study, 19 different environmental factors including solar irradiance (the amount of sunlight that reaches the Earth), cloud cover, rain, wind chill, barometric pressure and smog levels were accounted for.  However, it was discovered that what mattered most was the amount of time between sunrise and sunset. The other factors didn’t seem to have a significant association with emotional distress, provided that there was enough sunlight.
The results shouldn’t come as a surprise. It’s been estimated that as many as 20% of Americans are affected by SAD (Seasonal Affective Disorder) each winter, suffering from the blues, fatigue and in some cases, depression.
Another noteworthy benefit of sun exposure is Vitamin D. But when we talk about sun exposure to optimize vitamin D production, we’re really only looking at a small portion of the action spectrum of light, because ultraviolet B radiation is the only portion able to photosynthesize vitamin D in your skin. 
Furthermore, according to a paper published in the journal Dermato-Endocrinology, sunlight has the ability to influence your mood. Consider this example: Your body uses the near infrared light spectrum to produce mitochondrial energy and maintain systemic equilibrium. Near infrared also primes the cells in your retina for repair and regeneration.  With near-infrared playing such an important role in your body’s energy production, conclusions have been made that if you’re running low on adenosine triphosphate (ATP) due to insufficient amounts of sunlight exposure, you may feel sluggish and tired, and possibly depressed. 
It is a known fact that when it’s dark your melatonin levels increase which is why you may feel tired when the sun starts to set. During the winter months this may be as early as 4pm. In addition to this, research has also determined that UV light also stimulates epidermal cells known as keratinocytes to make beta-endorphins, which have a mood-boosting effect.
Also, it is a well-known fact that serotonin is released in response to sunlight – a hormone which helps elevate your mood and your energy. UVA generates nitric oxide (NO) in your skin, which has a number of beneficial effects on your body. In fact, it stimulates up to 60% of your blood to flow to your skin capillaries where they absorb this energy and infrared radiation. UVA also helps kill any infections in your blood while the infrared recharges your cellular battery.
Vitamin D Deficiency Predisposes You to Depression
Vitamin D appears to improve depression, possibly due to the fact that it’s a potent anti-inflammatory. Moreover, there’s ample evidence to suggest that vitamin D plays an important role in mental health. So, if you tend to feel blue over the fall and winter months, you’d be wise to get your levels of vitamin D checked out. If results show that your vitamin D levels are below 40 ng/mL, a vitamin D supplement will be advisable. 
In a 2006 study, seniors with vitamin D levels below 20 ng/ml were found to be more prone to depression than those with higher levels. Furthermore, a 2007 study suggested that vitamin D deficiency is responsible for symptoms of depression and anxiety in patients with fibromyalgia. Adding to this, vitamin D deficiency is also a well-recognized cause in SAD. In fact, in a 2011 study, the authors pointed out that ‘effective detection and treatment of inadequate vitamin D levels in persons with depression and other mental disorders may be an easy and cost-effective therapy which could improve patients' long-term health outcomes as well as their quality of life. 
It has been discovered that the optimal range for general physical and mental health appears to be between 40 and 70 ng/ml. So if you’re feeling depressed, get your vitamin D levels checked. 
One other noteworthy point to keep in mind is that when taking a vitamin D supplement, you also need to take vitamin K2 and magnesium as these nutrients work in tandem. And since vitamin D is fat-soluble, taking it with some form of healthy fat will help optimize absorption. 
Tips for Beating the Winter Blues
As mentioned above, light is a major factor in overcoming SAD and depression, as insufficient vitamin D levels. However, you can also help boost your mood naturally during the dark, cold winter with these tips: 
1. Exercising: Exercise has been found to work better than antidepressant drugs. It works by normalizing your insulin levels while simultaneously boosting the ‘feel good’ hormones in your brain. 
2. Going to sleep early: There is a link between depression and lack of sleep. Statistics show that of the approximately 18 million Americans with depression, more than half of them struggle with insomnia. While it was believed that insomnia was a symptom of depression, it now seems that insomnia may precede depression in some cases. As a general rule, aim for about 8 hours of sleep per night. You may also want to use a sleep tracker to help motivate you to get to bed earlier. 
3. Avoiding processed foods: Your diet should not be a factor that is overlooked. Foods can have an immense impact on your mood. So opt for a diet that consists of fresh, whole foods to support your mental health. 
4. Optimize your gut health: Fermented foods play an important role in optimal mental health and are vital for optimizing gut health. It’s important as your gut actually produces more mood-regulating serotonin than your brain does. 
5. Increase high quality and animal-based omega-3 fats: This may be the most important nutrient for optimal brain function. In addition, vitamin B12 deficiency may also contribute to depression, so it is worth getting checked out.
The Role of Vitamin D in Disease Prevention
Vitamin D plays a crucial role in disease prevention and maintaining optimal health. There are about 30,000 genes in the body, 3000 of which are affected by vitamin D. In one large-scale study it was found that optimal vitamin D can slash your risk of cancer by as much as 60%. So keeping your levels opitimized can help prevent at least 16 different types of cancer, including pancreatic, lung, ovarian, prostate and skin cancers. 
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Monday, April 08, 2019

Sunscreen promote vasodilation of blood vessels

Sunscreen protects the skin's blood vessel function from harmful ultraviolet radiation (UVR) exposure by protecting dilation of the blood vessels. Perspiration on the skin may also provide protection to the skin's blood vessels from sun damage, a recent study has suggested.

UVR from the sun has been well documented as a contributing factors to skin cancer and premature skin ageing. UVR has also been found to reduce nitric oxide-associated dilation of skin blood vessels ( vasodilation) by reducing the amount of nitric oxide available in the skin. Nitric oxide is a compound essential for blood vessel health.


Vasodilation of the skin's blood vessels plays an important role in regulating body temperature and responding to heat stress, both locally in the skin and throughout the body. 


Researchers studied the effect of UVR exposure with sunscreen or sweat on nitric oxide's ability to promote vasodilation of skin blood vessels. Healthy young adults with light-to-medium skin tone were exposed to UVR on one arm while the other arm served as a control and did not receive UVR treatment.


The dosage of UVR was roughly equivalent of spending an hour outside on a sunny day, but without the reddening of sunburn. Three sites on the UVR exposed arm of each participant were randomly assigned one of three treatments:
· One site received UVR only,
· A second site received UVR with a chemical sunscreen on the skin, and
A third site received UVR with simulated sweat on the skin. 


The UVR-only site was found to have less nitric oxide-associated vasodilation than in the control arm. However, the sunscreen- and sweat-treated sites did not show these reductions in nitric oxide-associated vasodilation.


 "Further, when sunscreen was applied prior to UVR, UVR exposure actually augmented [nitric oxide-associated vasodilation compared to [the control arm], or when sweat was on the skin. The presence of sunscreen or sweat on the skin may play a protective role against this effect [of UVR]," the research team wrote. 


"For those who spend a lot of time working, exercising or participating in other various activities outdoors, using sunscreen may protect not only against skin cancer but also against reductions in skin vascular function," wrote the first author of the study.


THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                         FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                  https:// kneereplacement-stickclub.blogspot.com/           


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Sunscreen protects the skin's blood vessel function from harmful ultraviolet radiation (UVR) exposure by protecting dilation of the blood vessels. Perspiration on the skin may also provide protection to the skin's blood vessels from sun damage, a recent study has suggested. UVR from the sun has been well-documented as a contributing factor to skin cancer and premature skin ageing. UVR has also been found to reduce nitric oxide-associated dilation of skin blood vessels (vasodilation) by reducing the amount of nitric oxide available in the skin. Nitric oxide is a compound essential for blood vessel health.

https://www.thehansindia.com/life-style/beauty/sunscreen-promote-vasodilation-of-blood-vessels-519191

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Tuesday, March 26, 2019

Serum from lupus patients affects enzyme responsible for producing nitric oxide


A new research has shown that the enzyme responsible for nitric oxide production stops working properly when exposed to serum from lupus patients.

Patients with lupus, an inflammatory disease in which the body's immune system attacks its own tissues, are on average seven to nine times more likely to develop heart disease than the general population. Younger women with lupus are 50 times as likely to develop the disease as young women without the disease.

The endothelium, the single layer of cells lining blood vessel walls, is thought to protect against heart disease. It does so in part by producing nitric oxide.

The article provides proof of the concept that the enzyme could be a therapeutic target for heart disease in lupus. Restoring the enzyme's function could also help protect lupus patients against kidney disease

The findings suggest that restoring the protective function of endothelial cells could be a strategy for treating heart disease more broadly.

"Our study demonstrates that therapies directed towards restoring the function of the enzyme that makes nitric oxide might be effective in restoring the function of the endothelium," explained the senior author on the article.

"So it's a proof of concept that allows us to move forward in studying the enzyme, nitric oxide synthase, or restoring its function as a target for vascular disease in lupus," he added.

"This is the first step in a long process of trying to identify therapeutics that might be useful for preventing this accelerated phenotype of  cardiovascular disease in lupus patients," said another researcher.

For the study, the team collected serum samples from a cohort of African American patients, specifically Gullah patients, with lupus who have been followed since 2003.

The team showed that exposing endothelial cells to serum from patients with lupus caused the enzyme that produced nitric oxide to quit working properly. That enzyme is known as endothelial nitric oxide synthase

Instead of producing the protective nitric oxide, it began producing super-oxide, which promoted damaging inflammation.

In essence, the enzyme lost its power to protect against heart disease and instead promoted conditions that could lead to it. A co-factor needed for the proper function of the enzyme had been rendered unusable by exposure of the endothelial cells to the serum of lupus patients.

Administering L-sepiapterin to the cells restored the enzyme's ability to produce nitric oxide by providing a new and more reliable source of that co-factor.

"If you try to give the co-factor itself, it's rapidly oxidised by the same process that leads to the  dysfunction of the enzyme," he explained. "So giving L-sepiapterin, a precursor to the co-factor, makes it less susceptible to that rapid breakdown."

L-sepiapterin is not currently approved for administration in humans. However, it is under investigation for the treatment of a number of diseases, including diabetic gastroparesis.

Before it can be administered to patients, both in animal models and in clinical trials, it will be necessary to confirm its efficacy and safety profile.

"Many people focus on controlling cholesterol to protect against the heart diseases," explained Buie. "Our study focuses the attention on making endothelial cells happy and functional. It identifies therapeutic targets on endothelial cells as being important."

That's not to say that controlling cholesterol and other lifestyle changes aren't important. They too can affect how well the endothelium protects against heart disease.

"Lifestyle modifications can affect the endothelium. The Western diet, characterised by highly processed foods that are high in saturated and trans-fat and low in good oils like omega-3 fatty acids, contributes to heart disease in everybody, not just lupus patients," he explains. "So changing to a healthy diet and becoming more active goes a long way."

But these findings suggest that pharmaceutically restoring endothelial function deserves further study as an additional therapeutic approach for patients with lupus and others at high risk of heart disease.

 
THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                         FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                  https:// kneereplacement-stickclub.blogspot.com/           

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