Antifungal and antidepressant drugs can effectively inhibit COVID-19 virus

 New research published in the British Journal of Pharmacology indicates that two currently available medications--an antifungal drug and an antidepressant--can effectively inhibit the virus that causes COVID-19 in laboratory cells.

Investigators found that the antifungal itraconazole and the antidepressant fluoxetine each blocked the production of infectious SARS-CoV-2 virus in cell culture lab tests. When either drug was used in combination with the antiviral drug remdesiver, the combination showed synergistic effects and inhibited the production of SARS-CoV-2 by more than 90%.

Preventive vaccination and therapeutic medicines against COVID-19 are both required to effectively combat pandemics caused by emerging zoonotic viruses such as SARS-CoV-2."

Ursula Rescher, PhD, Study Senior Author, University of Muenster, Germany

 

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A Team Of Scientist identifies four possible drugs to treat COVID-19

The team- Dr. Kamlendra Singh, an Associate Prof. at the Uni. of Missouri and his colleagues have    identified 4 antiviral drugs-including remdesivir that was originally developed to treat Ebola- which may be effective in inhibiting the replication of the novel coronavirus that causes COVID-19.

The researchers used computer-aided drug design to examine the effectiveness of remdesivir, 5-fluorouracil, ribavirin and favipiravir in treating COVID-19.

The study found that all 4 drugs were effective in inhibiting or blocking, the coronavirus' RNA proteins from making genomic copies of the novel coronavirus.

As researchers, we've an obligation to search for possible treatments given that so many people are dying from this virus, the researcher said.

These antiviral drugs, if they turn out to be effective, all have some limitations. But in the midst of a global pandemic, they're worth taking a deeper look at because based on our research, we've reason to believe that all of these drugs could potentially be effective in treating Covid-19, he said.

The researchers noted that SARS-Cov2 that causes Covid-19, like all viruses, can mutate and develop resistance to antiviral drugs.

Further testing in a lab setting and in patients is needed to better evaluate how the proposed treatments interact with the virus' RNA polymerase, they said.

Our goal is to help doctors by providing the options for possible treatments of Covid-19, and to ultimately contribute in improving the health outcomes of patients suffering from the infectious disease, he said.

As researchers, we're simply playing our part in the fight against the pandemic, he said.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

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Diabetes: These Leaves Can Lower Your Blood Sugar Levels Effectively

Diabetes is affecting millions today and it requires proper management to lead a normal life. It has become difficult for people to manage symptoms of diabetes. Diabetic diet can be one difficult topic to understand. If you are a diabetic, you need to add such foods to your diet which do not impact your blood sugar levels too much. Foods that can lower blood sugar levels are the best foods that a diabetic can add to his/her diet. Such foods will also help in diabetic treatment. One such remedy for diabetes which can control diabetes and reduce blood sugar levels is mango leaf. Mango leaves are loaded with properties that can help you manage diabetes. Diabetes management (controlling blood sugar levels) can also help you prevent the complications of diabetes. They can contribute to a drop in blood sugar levels. Various studies have also highlighted the benefits of mango leaves in managing diabetes by lowering blood sugar levels. However, more research is needed to testify how far they are beneficial.
 
 Mango leaves for diabetes
''Mango leaf extract (Mangiferin) has the ability to inhibit the enzyme alpha glucosidase, which helps reduce carbohydrate metabolism in intestine, and hence blood glucose levels. More research is needed to find out the exact dosage of the leaf extract,'' says Dr. Mahesh. D. M, Consultant Endocrinology, Aster CMI Hospital, Bangalore.

Mango leaves have the capability to improve insulin production and distribution of glucose. They can help in stabilising blood sugar levels. Mango leaves are also loaded with pectin, vitamin C and fibre. Together they are beneficial for both diabetes and cholesterol.

Healthy eating is good for everyone, but it's especially important for people who have diabetes. That's because healthy eating will keep your blood glucose (also called blood sugar) within a safe target range.

How to use mango leaves to lower blood sugar levels?

You need to follow a very simple method to use mango leaves for diabetes. All you need to do is take 10-15 mango leaves and boil them in water properly. After boiling the leaves properly, leave them overnight. Strain the water and drink it as the first thing in the morning on an empty stomach. Drinking this concoction every morning regularly for few months may have magical effects on your blood sugar levels.

Nonetheless, if you are a diabetic, you must carefully watch your diet. Follow all the instructions given by your doctor carefully to treat diabetes effectively. Eat a healthy and a balanced diet, exercise regularly and take less stress. 



This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
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The Mango Leaves Can Lower Your Blood Sugar Levels Effectively

Diabetes Diet: Managing blood sugar levels is important for diabetics. Did you know that mango leaves can exhibit surprising effects on controlling blood sugar and managing diabetes? Know how you can add mango leaves to your diabetes diet. 

Diabetes is affecting millions today and it requires proper management to lead a normal life. It has become difficult for people to manage symptoms of diabetes. Diabetic diet can be one difficult topic to understand. If you are a diabetic, you need to add such foods to your diet which do not impact your blood sugar levels too much. Foods that can lower blood sugar levels are the best foods that a diabetic can add to his/her diet.Such foods will also help in diabetic treatment. One such remedy for diabetes which can control diabetes and reduce blood sugar levels is mango leaf. Mango leaves are loaded with properties that can help you manage diabetes. They can contribute to a drop in blood sugar levels. Various studies have also highlighted the benefits of mango leaves in managing diabetes by lowering blood sugar levels. However, more research is needed to testify how far they are beneficial.
Diabetes diet: Mango leaves for diabetes

''Mango leaf extract (Mangiferin) has the ability to inhibit the enzyme alpha glucosidase, which helps reduce carbohydrate metabolism in intestine, and hence blood glucose levels. More research is needed to find out the exact dosage of the leaf extract,'' says an Endocrinology Consultant.

Mango leaves have the capability to improve insulin production and distribution of glucose. They can help in stabilising blood sugar levels. Mango leaves are also loaded with pectin, vitamin C and fibre. Together they are beneficial for both diabetes and cholesterol. 

Diabetes diet: How to use mango leaves to lower blood sugar levels?

You need to follow a very simple method to use mango leaves for diabetes. All you need to do is take 10-15 mango leaves and boil them in water properly. After boiling the leaves properly, leave them overnight. Strain the water and drink it as the first thing in the morning on an empty stomach. 

Drinking this concoction every morning regularly for few months may have magical effects on your blood sugar levels.

Nonetheless, if you are a diabetic, you must carefully watch your diet. Follow all the instructions given by your doctor carefully to treat diabetes effectively. Eat a healthy and a balanced diet, exercise regularly and take less stress.


this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   
https://gscrochetdesigns.blogspot.com. one can see my crochet creations 
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement    

The Potential Risk of Grapefruit Juice

Citrus fruits are considered to be very healthy, thanks to their high vitamin C content as well as the many minerals and other nutrients they contain. However, ingesting grapefruit juice can lead to severe poisoning when mixed with certain substances. A variety of medical studies in recent years found that combining grapefruit juice with certain medications can lead to an overdose. This article will discuss the reasons for these results, and list the medications you absolutely cannot mix with grapefruit.

The Grapefruit/Medication Connection The human body produces an enzyme called CYO3A4 that, among other things, helps break down certain chemicals before they are absorbed into the bloodstream. Grapefruits contain a chemical that inhibits the CYO3A4 enzyme’s functions, which leads to more of the medication being absorbed into the bloodstream. When the level of medication in the blood is too high, you enter a state of overdose, which can lead to exacerbated side-effects and even poisoning. Other Citrus Fruits The inhibiting chemical in grapefruit can also be found in other citrus fruits, such as pomelo, limes, and bitter oranges (a type of orange that is very bitter and is mainly used in jams). It’s important to mention that other species of oranges, as well as lemons - are safe to ingest, as they don’t contain the aforementioned chemical. Potential Severity of Reactions It’s difficult to predict the severity of reaction grapefruit juice will have on one's body, as it can be affected by many variables. Different juices contain different levels of the inhibiting chemical, meaning that each type of juice can have a different level of effect. Additionally, the quantity of juice consumed can have a drastically varied effect according to one's weight. Medications that Should Not Be Taken with Grapefruit Juice: There are currently more than 85 different medications that should not be taken with grapefruit juice, and new drugs join the list every year. The following list shows the drugs that pose the most danger when taken with Grapefruit: Heart Rate and Blood Pressure Medication Generic name Commercial names Amlodipine  Norvasc Amiodarone Procor, Amiodacore, Amiocor Felodipine  Logimax, Penedil Nifedipine  Osmo-Adalat, Nifedipine-Teva, Pressolat, Megalat Nimodipine  Nimotop Quinidin  Quiniduran Verapamil Verapress, Apoacor, Ikacor, Ikapress, Veracor Lipid Lowering Medication Generic name Commercial names Atorvastatin Lipitor Lovastatin Lovalip Simvastatin Simovil, Simvacor, Simvastatin-Teva Tranquilizers and Psychiatric Medication Generic name Commercial names Buspirone Buspirol, Sorbon Clomipramine Anafranil, Maronil Diazepam Assival, Diaz, Valium Midazolam Dormicum, Midazol, Midazolam Pimozide Orap Forte Sertraline Lustral Other (Immunosuppressants, antihistamines, etc.) Generic name Commercial names Carbamazepine Carbi, Tegretol, Teril, Timonil Cisapride Prepulsid Cyclosporine Sangcya, Sandimmun, Deximune Itraconazole Sporanox Saquinavir Invirase, Fortovase Sirolimus Rapamune Tacrolimus Prograf

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/    

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