A Team Of Scientist identifies four possible drugs to treat COVID-19
The team- Dr. Kamlendra Singh, an Associate Prof. at the Uni. of Missouri and his colleagues have identified 4 antiviral drugs-including remdesivir that was originally developed to treat Ebola- which may be effective in inhibiting the replication of the novel coronavirus that causes COVID-19.
The researchers used computer-aided drug design to examine the effectiveness of remdesivir, 5-fluorouracil, ribavirin and favipiravir in treating COVID-19.
The study found that all 4 drugs were effective in inhibiting or blocking, the coronavirus' RNA proteins from making genomic copies of the novel coronavirus.
As researchers, we've an obligation to search for possible treatments given that so many people are dying from this virus, the researcher said.
These antiviral drugs, if they turn out to be effective, all have some limitations. But in the midst of a global pandemic, they're worth taking a deeper look at because based on our research, we've reason to believe that all of these drugs could potentially be effective in treating Covid-19, he said.
The researchers noted that SARS-Cov2 that causes Covid-19, like all viruses, can mutate and develop resistance to antiviral drugs.
Further testing in a lab setting and in patients is needed to better evaluate how the proposed treatments interact with the virus' RNA polymerase, they said.
Our goal is to help doctors by providing the options for possible treatments of Covid-19, and to ultimately contribute in improving the health outcomes of patients suffering from the infectious disease, he said.
As researchers, we're simply playing our part in the fight against the pandemic, he said.
The researchers used computer-aided drug design to examine the effectiveness of remdesivir, 5-fluorouracil, ribavirin and favipiravir in treating COVID-19.
The study found that all 4 drugs were effective in inhibiting or blocking, the coronavirus' RNA proteins from making genomic copies of the novel coronavirus.
As researchers, we've an obligation to search for possible treatments given that so many people are dying from this virus, the researcher said.
These antiviral drugs, if they turn out to be effective, all have some limitations. But in the midst of a global pandemic, they're worth taking a deeper look at because based on our research, we've reason to believe that all of these drugs could potentially be effective in treating Covid-19, he said.
The researchers noted that SARS-Cov2 that causes Covid-19, like all viruses, can mutate and develop resistance to antiviral drugs.
Further testing in a lab setting and in patients is needed to better evaluate how the proposed treatments interact with the virus' RNA polymerase, they said.
Our goal is to help doctors by providing the options for possible treatments of Covid-19, and to ultimately contribute in improving the health outcomes of patients suffering from the infectious disease, he said.
As researchers, we're simply playing our part in the fight against the pandemic, he said.
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