Early exposure to chmeicals in toothpaste, make-up advances girls’ puberty

Girls exposed to chemicals commonly found in toothpaste, makeup, soap and other personal care products before birth may hit puberty at an early age, finds a new study.

The study found that in-vitro exposure to chemicals in personal care products such as phthalates — found in scented products like perfumes, soaps and shampoos — parabens — used as preservatives in cosmetics — and phenols — which include triclosan — advances pubertal age in girls.

Early puberty in girls have been linked with increased risk of mental illness, breast and ovarian cancer; and testicular cancer in boys.

However, the association was not observed in boys.

“We know that some of the things we put on our bodies are getting into our bodies, either because they pass through the skin or we breathe them in or we inadvertently ingest them,” said a Prof.

“We wanted to know what effect exposure to these chemicals has during certain critical windows of development, which include before birth and during puberty,” the Prof. added.

For the study,  the team included 338 children — 159 boys and 179 girls.

The findings showed that more than 90 per cent of urine samples of both mothers and children showed detectable concentrations of phthalates, parabens and phenols.

However, there was an exception of triclosan which was present in approximately 70 per cent of the samples.

Every time the concentrations of diethyl phthalate and triclosan in the mother’s urine doubled, pubertal development in girls advanced approximately by one month.

In addition, girls who had higher concentrations of parabens in their urine at age nine also experienced puberty at younger ages.

However, it is unclear if the chemicals were causing the shift, or if girls who reached puberty earlier were more likely to start using personal care products at younger ages, the researchers noted, adding the need for more studies.
  
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Here’s how mango pulp helps you fight cancer, inflammation

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 Here’s one more reason to make mangoes your favourite fruit. Did you know they have numerous compounds that have antioxidant properties? These include vitamin C and beta carotene, as well as several polyphenolic compounds including gallic acid and their larger polymers gallotannins, which have been linked to anti-cancer and anti-inflammatory activities in previous in-vitro and in-vivo studies.

The absorption, metabolism, and excretion of mango galloyl derivatives have not previously been investigated in humans. In this human pilot trial published in the journal of Molecular Nutrition & Food Research, 11 healthy volunteers between the ages of 21 and 38 years old consumed 400gm/day of mango-pulp for 10 days, with blood and urine samples taken on days one and 10 of the study following mango consumption.

 Participants refrained from consuming dietary supplements and foods which could be sources of gallic acid such as berries, grapes, and tea for one week prior to the beginning of the study and during the 10 days of mango consumption.

 Seven metabolites of gallic acid were identified in the urine of healthy volunteers, and of those two microbial metabolites were found to be significantly more excreted following 10 days of mango consumption. The presence of gallic acid and pyrogallol metabolites in human urine after the consumption 400g of mango indicates the absorption, metabolism, and excretion of mango galloyl derivative and confirms the bioavailability of these mango-derived metabolites. This study has been published in Molecular Nutrition and Food Research.