Researchers have
developed a new test that could help doctors detect Alzheimer's disease
eight years before the first symptoms occur.
Using current techniques, Alzheimer's disease, the most frequent cause
of dementia, can only be detected once the typical plaques have formed
in the brain.
At this point, therapy seems no longer possible. However, the first
changes caused by Alzheimer's take place on the protein level up to 20
years sooner.
"Once amyloid plaques have formed, it seems that the disease can no
longer be treated," said study co-author Andreas Nabers from
Ruhr-University Bochum in Germany.
https://www.thehansindia.com/life-style/health/blood-test-to-spot-alzheimers-before-symptoms-occur-526646 While fibre-ricj diets are an effective means of cancer prevention,
their possible roles in cancer progression and treatment remains poorly
understood. According to recent findings, the right combination of diet
and bacteria limits cancer progression.
The diet of a person can have
significant effects on the gut microbiome, i.e. the populations of
microorganisma such as bacteria which live in the human gut. It is well
recognised that dietary habits through complex meatbolic interactions
contribute to cancer prevention. More specifically, diets rich in fibre
reduce the risk if developing specific cancers such as colorectal
cancer.
The team of researhers founf that a combination of
prebiotics, such as dietary fibre, and probiotics, i.e., specific
beneficial bacteria, reduce the expression of pro-carcinogenic and drug
resistance genes. The combination leads to metabolic changes that affect
the growth of cancer cells and may help treat diseases such as CRC.
In
order to study diet-microbiome-host interactions, the biologists worked
with " Human-Mircobial X ( cross)-talk"- HuMiX, a unique in vitro model
of the gut ( gut -on-a-chip), which allows the cultivation of human
intestinal cells together with bacteria under representative conditions.
As
part of the study, publishes, the researchers investigated the effects
of ietary regimens and a specific probiotic on CRC cells.
In contrast
to individual fibre-rich or probiotic treatments, it was only the
combination of fibre and probiotics that led to the observed beneficial
effects.
Together with their collaborators, the researchers
integrated a computer-based metabolic model of the interactions between
diet, host and microbiome. They dientified the effects of the combined
treatment - the downregulation of genes associated with colorectal
cancer and drug resistance as well as the attentuation of self-renewal
capacity of the cancer cells.
Importantly, through careful molecular
analyses, they also identified the cocktail of molecules produced by the
combination, thereby providing a mechanistic basis for the observed
beneficial effects.
Cyrrently, cancer patients are not provided with
evidence-based personalised dietary interventions during chemotherapy
treatment. Our results provide support for exploiting the
food-microbiome interactions as a supportive therapeuric approach in
anti-cancer therapy said the lead author of the study.
I hope that
our results will reach patients and medical practioner in their
respective fields and that in the future more effort is put in including
personalised dietary recommendations into cancer treatment plans, the
author asserted.
According to the researchers, this is especially the
case in CRC, where the microbiome has increasingly gained importance
over the last couple of years. A deeper understanding of the
microbiome-host interaction could lead to new therapeutic strategies for
CRC patientsWhile fibre-ricj diets are an effective means of cancer
prevention, their possible roles in cancer progression and treatment
remains poorly understood. According to recent findings, the right
combination of diet and bacteria limits cancer progression.
The diet
of a person can have significant effects on the gut microbiome, i.e. the
populations of microorganisma such as bacteria which live in the human
gut. It is well recognised that dietary habits through complex meatbolic
interactions contribute to cancer prevention. More specifically, diets
rich in fibre reduce the risk if developing specific cancers such as
colorectal cancer.
The team of researhers founf that a combination of
prebiotics, such as dietary fibre, and probiotics, i.e., specific
beneficial bacteria, reduce the expression of pro-carcinogenic and drug
resistance genes. The combination leads to metabolic changes that affect
the growth of cancer cells and may help treat diseases such as CRC.
In
order to study diet-microbiome-host interactions, the biologists worked
with " Human-Mircobial X ( cross)-talk"- HuMiX, a unique in vitro model
of the gut ( gut -on-a-chip), which allows the cultivation of human
intestinal cells together with bacteria under representative conditions.
As
part of the study, publishes, the researchers investigated the effects
of ietary regimens and a specific probiotic on CRC cells.
In contrast
to individual fibre-rich or probiotic treatments, it was only the
combination of fibre and probiotics that led to the observed beneficial
effects.
Together with their collaborators, the researchers
integrated a computer-based metabolic model of the interactions between
diet, host and microbiome. They dientified the effects of the combined
treatment - the downregulation of genes associated with colorectal
cancer and drug resistance as well as the attentuation of self-renewal
capacity of the cancer cells.
Importantly, through careful molecular
analyses, they also identified the cocktail of molecules produced by the
combination, thereby providing a mechanistic basis for the observed
beneficial effects.
Cyrrently, cancer patients are not provided with
evidence-based personalised dietary interventions during chemotherapy
treatment. Our results provide support for exploiting the
food-microbiome interactions as a supportive therapeuric approach in
anti-cancer therapy said the lead author of the study.
I hope that
our results will reach patients and medical practioner in their
respective fields and that in the future more effort is put in including
personalised dietary recommendations into cancer treatment plans, the
author asserted.
According to the researchers, this is especially the
case in CRC, where the microbiome has increasingly gained importance
over the last couple of years. A deeper understanding of the
microbiome-host interaction could lead to new therapeutic strategies for
CRC patients.