Right combination of diet and bacteria limits cancer progression

While fibre-rich diets are an effective means of cancer prevention, their possible roles in cancer progression and treatment remains poorly understood. According to recent findings, the right combination of diet and bacteria limits cancer progression.

The diet of a person can have significant effects on the gut microbiome, i.e. the populations of microorganisma such as bacteria which live in the human gut. It is well recognised that dietary habits through complex meatbolic interactions contribute to cancer prevention. More specifically, diets rich in fibre reduce the risk if developing specific cancers such as colorectal cancer.

The team of researhers founf that a combination of prebiotics, such as dietary fibre, and probiotics, i.e., specific beneficial bacteria, reduce the expression of pro-carcinogenic and drug resistance genes. The combination leads to metabolic changes that affect the growth of cancer cells and may help treat diseases such as CRC.

In order to study diet-microbiome-host interactions, the biologists worked with " Human-Mircobial X ( cross)-talk"- HuMiX, a unique in vitro model of the gut ( gut -on-a-chip), which allows the cultivation of human intestinal cells together with bacteria under representative conditions.

As part of the study, publishes, the researchers investigated the effects of ietary regimens and a specific probiotic on CRC cells.

In contrast to individual fibre-rich or probiotic treatments, it was only the combination of fibre and probiotics that led to the observed beneficial effects.

Together with their collaborators, the researchers integrated a computer-based metabolic model of the interactions between diet, host and microbiome. They identified the effects of the combined treatment - the downregulation of genes associated with colorectal cancer and drug resistance as well as the attentuation of self-renewal capacity of the cancer cells.

Importantly, through careful molecular analyses, they also identified the cocktail of molecules produced by the combination, thereby providing a mechanistic basis for the observed beneficial effects.

Currently, cancer patients are not provided with evidence-based personalised dietary interventions during chemotherapy treatment. Our results provide support for exploiting the food-microbiome interactions as a supportive therapeuric approach in anti-cancer therapy said the lead author of the study.

I hope that our results will reach patients and medical practioner in their respective fields and that in the future more effort is put in including personalised dietary recommendations into cancer treatment plans, the author asserted.

According to the researchers, this is especially the case in CRC, where the microbiome has increasingly gained importance over the last couple of years. A deeper understanding of the microbiome-host interaction could lead to new therapeutic strategies for CRC patientsWhile fibre-ricj diets are an effective means of cancer prevention, their possible roles in cancer progression and treatment remains poorly understood. According to recent findings, the right combination of diet and bacteria limits cancer progression.

The diet of a person can have significant effects on the gut microbiome, i.e. the populations of microorganisma such as bacteria which live in the human gut. It is well recognised that dietary habits through complex meatbolic interactions contribute to cancer prevention. More specifically, diets rich in fibre reduce the risk if developing specific cancers such as colorectal cancer.

The team of researhers founf that a combination of prebiotics, such as dietary fibre, and probiotics, i.e., specific beneficial bacteria, reduce the expression of pro-carcinogenic and drug resistance genes. The combination leads to metabolic changes that affect the growth of cancer cells and may help treat diseases such as CRC.

In order to study diet-microbiome-host interactions, the biologists worked with " Human-Mircobial X ( cross)-talk"- HuMiX, a unique in vitro model of the gut ( gut -on-a-chip), which allows the cultivation of human intestinal cells together with bacteria under representative conditions.

As part of the study, publishes, the researchers investigated the effects of ietary regimens and a specific probiotic on CRC cells.

In contrast to individual fibre-rich or probiotic treatments, it was only the combination of fibre and probiotics that led to the observed beneficial effects.

Together with their collaborators, the researchers integrated a computer-based metabolic model of the interactions between diet, host and microbiome. They dientified the effects of the combined treatment - the downregulation of genes associated with colorectal cancer and drug resistance as well as the attentuation of self-renewal capacity of the cancer cells.

Importantly, through careful molecular analyses, they also identified the cocktail of molecules produced by the combination, thereby providing a mechanistic basis for the observed beneficial effects.

Currently, cancer patients are not provided with evidence-based personalised dietary interventions during chemotherapy treatment. Our results provide support for exploiting the food-microbiome interactions as a supportive therapeuric approach in anti-cancer therapy said the lead author of the study.

I hope that our results will reach patients and medical practioner in their respective fields and that in the future more effort is put in including personalised dietary recommendations into cancer treatment plans, the author asserted.

According to the researchers, this is especially the case in CRC, where the microbiome has increasingly gained importance over the last couple of years. A deeper understanding of the microbiome-host interaction could lead to new therapeutic strategies for CRC patients.

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Researchers have developed a new test that could help doctors detect Alzheimer's disease eight years before the first symptoms occur. Using current techniques, Alzheimer's disease, the most frequent cause of dementia, can only be detected once the typical plaques have formed in the brain. At this point, therapy seems no longer possible. However, the first changes caused by Alzheimer's take place on the protein level up to 20 years sooner. "Once amyloid plaques have formed, it seems that the disease can no longer be treated," said study co-author Andreas Nabers from Ruhr-University Bochum in Germany.

https://www.thehansindia.com/life-style/health/blood-test-to-spot-alzheimers-before-symptoms-occur-526646 While fibre-ricj diets are an effective means of cancer prevention, their possible roles in cancer progression and treatment remains poorly understood. According to recent findings, the right combination of diet and bacteria limits cancer progression.
The diet of a person can have significant effects on the gut microbiome, i.e. the populations of microorganisma such as bacteria which live in the human gut. It is well recognised that dietary habits through complex meatbolic interactions contribute to cancer prevention. More specifically, diets rich in fibre reduce the risk if developing specific cancers such as colorectal cancer.
The team of researhers founf that a combination of prebiotics, such as dietary fibre, and probiotics, i.e., specific beneficial bacteria, reduce the expression of pro-carcinogenic and drug resistance genes. The combination leads to metabolic changes that affect the growth of cancer cells and may help treat diseases such as CRC.
In order to study diet-microbiome-host interactions, the biologists worked with " Human-Mircobial X ( cross)-talk"- HuMiX, a unique in vitro model of the gut ( gut -on-a-chip), which allows the cultivation of human intestinal cells together with bacteria under representative conditions.
As part of the study, publishes, the researchers investigated the effects of ietary regimens and a specific probiotic on CRC cells.
In contrast to individual fibre-rich or probiotic treatments, it was only the combination of fibre and probiotics that led to the observed beneficial effects.
Together with their collaborators, the researchers integrated a computer-based metabolic model of the interactions between diet, host and microbiome. They dientified the effects of the combined treatment - the downregulation of genes associated with colorectal cancer and drug resistance as well as the attentuation of self-renewal capacity of the cancer cells.
Importantly, through careful molecular analyses, they also identified the cocktail of molecules produced by the combination, thereby providing a mechanistic basis for the observed beneficial effects.
Cyrrently, cancer patients are not provided with evidence-based personalised dietary interventions during chemotherapy treatment. Our results provide support for exploiting the food-microbiome interactions as a supportive therapeuric approach in anti-cancer therapy said the lead author of the study.
I hope that our results will reach patients and medical practioner in their respective fields and that in the future more effort is put in including personalised dietary recommendations into cancer treatment plans, the author asserted.
According to the researchers, this is especially the case in CRC, where the microbiome has increasingly gained importance over the last couple of years. A deeper understanding of the microbiome-host interaction could lead to new therapeutic strategies for CRC patientsWhile fibre-ricj diets are an effective means of cancer prevention, their possible roles in cancer progression and treatment remains poorly understood. According to recent findings, the right combination of diet and bacteria limits cancer progression.
The diet of a person can have significant effects on the gut microbiome, i.e. the populations of microorganisma such as bacteria which live in the human gut. It is well recognised that dietary habits through complex meatbolic interactions contribute to cancer prevention. More specifically, diets rich in fibre reduce the risk if developing specific cancers such as colorectal cancer.
The team of researhers founf that a combination of prebiotics, such as dietary fibre, and probiotics, i.e., specific beneficial bacteria, reduce the expression of pro-carcinogenic and drug resistance genes. The combination leads to metabolic changes that affect the growth of cancer cells and may help treat diseases such as CRC.
In order to study diet-microbiome-host interactions, the biologists worked with " Human-Mircobial X ( cross)-talk"- HuMiX, a unique in vitro model of the gut ( gut -on-a-chip), which allows the cultivation of human intestinal cells together with bacteria under representative conditions.
As part of the study, publishes, the researchers investigated the effects of ietary regimens and a specific probiotic on CRC cells.
In contrast to individual fibre-rich or probiotic treatments, it was only the combination of fibre and probiotics that led to the observed beneficial effects.
Together with their collaborators, the researchers integrated a computer-based metabolic model of the interactions between diet, host and microbiome. They dientified the effects of the combined treatment - the downregulation of genes associated with colorectal cancer and drug resistance as well as the attentuation of self-renewal capacity of the cancer cells.
Importantly, through careful molecular analyses, they also identified the cocktail of molecules produced by the combination, thereby providing a mechanistic basis for the observed beneficial effects.
Cyrrently, cancer patients are not provided with evidence-based personalised dietary interventions during chemotherapy treatment. Our results provide support for exploiting the food-microbiome interactions as a supportive therapeuric approach in anti-cancer therapy said the lead author of the study.
I hope that our results will reach patients and medical practioner in their respective fields and that in the future more effort is put in including personalised dietary recommendations into cancer treatment plans, the author asserted.
According to the researchers, this is especially the case in CRC, where the microbiome has increasingly gained importance over the last couple of years. A deeper understanding of the microbiome-host interaction could lead to new therapeutic strategies for CRC patients.