Thursday, March 19, 2020

These Common Household Products Can Destroy the Novel Coronavirus

News of stores running out of hand-sanitizing gels and chlorine wipes may have you worried about how to protect your family at home as COVID-19 spreads. But plain old hand soap will go a long way.

“It isn’t possible to disinfect every surface you touch throughout your day,” says Stephen Thomas, M.D., chief of infectious diseases and director of global health at Upstate Medical University in Syracuse. “The planet is covered with bacteria and viruses, and we’re constantly in contact with these surfaces, so hand-washing is still your best defense against COVID-19.” 
You need to amp up your typical cleaning routine only if someone in the household exhibits signs and symptoms of a respiratory infection, or if you live in an area with known cases of COVID-19. In that scenario, Thomas says, “Clean high-traffic areas that get touched frequently, such as kitchen counters and bathroom faucets, three times a day with a product that kills viruses.”

The good news is that coronaviruses are some of the easiest types of viruses to kill with the appropriate product, according to the Environmental Protection Agency. “It has an envelope around it that allows it to merge with other cells to infect them,” explains Thomas. “If you disrupt that coating, the virus can’t do its job.”

Even if you can't get your hands on hand sanitizer or Clorox wipes, below are a number of cleaning products you probably have around the house already, and that stores are more likely to have in stock, that are effective in deactivating the novel coronavirus. We also tell you the products that don’t work, and when you can expect retailers to stock back up on cleaning supplies.

Cleaning Products That Destroy Coronavirus

Soap and Water
Just the friction from scrubbing with soap and water can break the coronavirus’s protective envelope. “Scrub like you’ve got sticky stuff on the surface and you really need to get it off,” says Richard Sachleben, an organic chemist and member of the American Chemical Society. Discard the towel or leave it in a bowl of soapy water for a while to destroy any virus particles that may have survived. 


Bleach
The Centers for Disease Control and Prevention recommends a diluted bleach solution (⅓ cup bleach per 1 gallon of water or 4 teaspoons bleach per 1 quart of water) for virus disinfection. Wear gloves while using bleach, and never mix it with anything except water. (The only exception is when doing laundry with detergent.)


“Bleach works great against viruses,” Sachleben says. Just don’t keep the solution for longer than a few days because bleach will degrade certain plastic containers.

Bleach can also corrode metal over time, so Sachleben recommends that people not get into the habit of cleaning their faucets and stainless steel products with it. Because bleach is harsh for many countertops as well, you should rinse surfaces with water after disinfecting to prevent discoloration or damage to the surface. 

Isopropyl Alcohol
Alcohol solutions with at least 70 percent alcohol are effective against coronavirus. Do not dilute the alcohol solution. Alcohol is generally safe for all surfaces but can discolor some plastics, Sachleben says.


Hydrogen Peroxide
According to the CDC, household (3 percent) hydrogen peroxide is effective in deactivating rhinovirus, the virus that causes the common cold, within 6 to 8 minutes of exposure. Rhinovirus is more difficult to destroy than coronaviruses, so hydrogen peroxide should be able to break down coronavirus in less time. Pour it undiluted into a spray bottle and spray it on the surface to be cleaned, but let it sit on the surface for several minutes. 


Hydrogen peroxide is not corrosive, so it’s okay to use it on metal surfaces. But similar to bleach, it can discolor fabrics if you accidentally get in on your clothes. “It’s great for getting into hard-to-reach crevices,” Sachleben says. “You can pour it on the area and you don’t have to wipe it off because it essentially decomposes into oxygen and water.”

What Not to Use Against Coronavirus

Homemade Hand Sanitizer
You’re probably seeing all sorts of hand sanitizer recipes floating around your social media and the internet, but Thomas, at Upstate Medical in Syracuse, advises against making your own. “People don’t know the right ratios to use, and the internet won’t give you the right answer,” he warns. “Not only can you hurt yourself, but it could give you a false sense of security.” 


Sachleben seconds that advice. “I’m a professional chemist, and I don’t mix my own disinfectant products at home,” he says. “Companies spend a bunch of time and money to pay chemists specifically to formulate hand sanitizers that work and that are safe. If you make it yourself, how can you know if it’s stable or if it works?”

Vodka
There are widely circulated recipes on the internet using vodka to combat coronavirus. A couple of vodka makers, including Tito’s and Smirnoff, have already come out with statements telling their customers that their 80-proof product does not contain enough ethyl alcohol (40 percent compared with the 70 percent required) to kill the coronavirus. 


Distilled White Vinegar
Disinfection recommendations using vinegar are popular online, but there is no evidence that they are effective against coronavirus. 


This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement

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Saturday, February 29, 2020

Cancer chemical from common gut microbe

Many common gut bacteria carry cancer-causing mutations, says a new study published in the journal Nature on the 27th February 2020.

There are trillions of bacteria living in and on the human body. The gut bacteria within human individuals play a unique role in both health and disease. They prime immunity during the formative 2-week period just after birth, they prevent the invasion and overgrowth of pathogenic bacterial species and maintain the integrity of the intestinal epithelium, among other things.

A potential pathogen that occurs commonly in the human gut is the bacterium Escherichia coli (E. coli).

Mutations and tumor development

Cancer cells develop because of specific mutations in the DNA, which cause unbridled proliferation and loss of mature characteristics, in many cases, resulting eventually in tumor growth.  Mutations are often caused by exposure to ultraviolet light or smoking. Repeated exposures increase the chances of harmful mutations accumulating within a cell, causing cancerous transformation.

It is known that every type of DNA damage causes a visible pattern of DNA damage called a mutational signature or footprint. Many such footprints are already known, which record the effect of agents such as ultraviolet exposure or smoking. Thus, the exposure history can often be known by looking at the mutational footprint. However, the mutagenic effects of gut bacteria were unknown until recently.

As researcher Ruben van Boxtel explains, “These signatures can have great value in determining causes of cancer and may even direct treatment strategies. We can identify such mutational footprints in several forms of cancer, also in pediatric cancer. This time we wondered if the genotoxic bacteria also leave their unique distinguishing mark in the DNA.”

The study
In the current study, the investigators looked at intestinal organoids, which are tiny masses of intestinal tissue grown as a mini-organ in the laboratory, to test whether a specific strain of E. coli induces DNA mutations. This strain is found in a fifth of all adults.

The researchers cultured gut organoids which were then exposed for five months to this strain of E. coli, which produces a genotoxin, a chemical that harms the human DNA. The chemical involved is called colibactin. The gene-modifying effects of this toxin mean that it could harm humans by causing mutations.

After 5 months of exposure, the organoid cells were subjected to DNA extraction, and the kind, as well as the number of mutations due to the bacterial presence, was analyzed.


The results

The researchers found that there was indeed a unique pattern to the mutations that occurred within the organoid cells. In other words, the tested strain of E. coli did cause a distinctive mutation pattern to occur within human cells.

“I remember the excitement when the first signatures appeared on the computer screen,” says Axel Rosendahl Huber. “We had hoped for some indication of a signature that we could follow up on in other experiments, but the patterns were more striking than any signature we had analyzed before.”

The signature consisted of two mutations that occurred together, one being the change of an adenine base (A) to any of the other four DNA bases, and the other the loss of a single A in long polyA stretches. There was also another additional A on the other strand of the DNA helix, located at a distance of 3-4 bases away from the site of mutation.


Delving deeper

At the final stage, the team began to explore the way colibactin caused DNA damage. They found out its molecular structure and how this acted upon the DNA. The chief finding was that colibactin could bind two A’s simultaneously, causing a crosslink to form between them. This could, in their opinion, explain why the colibactin caused its unique mutational pattern.

The next step was to trace this signature in other cells, namely, the cells of patients with cancer. Furthermore, the researchers did not skimp on this. They examined thousands of mutations in over 5,000 cancers, of many different types.

One exciting finding stood out: more than 5% of bowel cancers showed this footprint, but it was present in less than one in hundred of other cancer DNAs. Among these, the tissue was known to be exposed to the same bacterium – such as cancer of the mouth or the urinary bladder.

Ominously, this tell-tale pattern was also found within the DNA of patients with colon cancer, which may well indicate a link between the bacteria and the disease. Jens Puschhof says, “It is known that E. coli can infect these organs, and we are keen to explore if its genotoxicity may act in other organs beyond the colon.”


Implications

This study marks the first time a direct connection has been found between the human microbiome and the mutations that cause cancers to develop.

The frightening thing is that, in the words of Hans Clever of the Hubrecht Institute, which ran the study, “There are probiotics currently on the market that contain genotoxic strains of E. coli. Some of these probiotics are also used in clinical trials as we speak. These E. coli strains should be critically re-evaluated in the lab.”

He explains that despite the short-term relief for certain painful conditions such as fibromyalgia or irritable bowel syndrome, when used for a short period, they could cause cancer after decades.

The finding of this mutation signature could help screen patients for their chances of developing a tumor, based on the presence of this genotoxic strain. It is estimated that it occurs in up to a fifth of healthy individuals. It is even possible that using the right antibiotics, these bacteria could be eradicated, and the chances of tumor development markedly reduced. Or at least, it could help detect these tumors very early in their course.


This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement
 

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Tuesday, July 23, 2019

Protect yourself from common monsoon diseases

The rainy season certainly brings respite from the sweltering heat, but this season is infamous for attacking one's immunity and making one prone to various infections. The season brings a host of infections right from mosquito-borne diseases like chikungunya, typhoid, and dengue to water-borne illnesses liked leptospirosis (a bacterial infection transmitted through urine or excreta of rats and cattle).
In such circumstances, it is important to boost your immune system by making healthier food choices.
Here are some common home remedies that can help you boost your immune system.

1) Turmeric

Antimicrobial, antioxidant, and anti-inflammatory in nature, turmeric is an excellent spice to keep different types of infections at bay. This spice commonly found in every Indian household enhances the immune system and flushes out toxins from the body. Add this yellow spice in your food or you can even mix a pinch of turmeric in your milk to stay protected this rainy season. 

2) Ginger

Ginger is another important spice that is popular for its diverse health benefits. The root is packed with essential nutrients that promote your immunity, supports digestion, helps with motion sickness and reduces pain.

3) Cinnamon

This aromatic spice has been valued for its medicinal properties for thousands of years. Cinnamon can cure a sore throat and prevent viral infections that are common during the monsoon season. This spice has also been linked to a reduced risk of heart disease, which is the most common cause of premature deaths across the globe.

4) Fenugreek seeds

Fenugreek seeds are packed with antioxidants and other essential nutrients that are good for the immune system. The spice keeps the immune system strong and helps to cut down water retention in the body.  

5) Herbal tea or green tea

Having herbal teas or even green tea can help boost our immunity to stay fit in this season. Tea is loaded with antioxidants that help to keep cold, cough and other infections at bay. Sipping a warm cup of tea also helps soothe the throat and keep the tonsils in check.

6) Eat hot foods

Don't eat cold and stale food in this season as they make you prone to bacteria and infections. Having cold food can lead to stomach infections, loose bowels, and food poisoning. Drinking lukewarm water is also a good option for proper digestion of food. It helps to flush out the toxins from the body and cleanse your system.

7) Tips

Keep your surroundings clean
-Maintain good hygiene
-Take bath properly if you get drenched in the rain
-Do not eat street foods

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                  https:// kneereplacement-stickclub.blogspot.com/                                                                      FOR CROCHET DESIGNS                                                                                                    
                                https://gscrochetdesigns.blogspot.com

 

 

 

 

 

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Saturday, July 06, 2019

Strain of common cold virus can help cure bladder cancer

A strain of the common cold virus can help infect and destroy bladder cancer cells, according to a study.
Researchers investigated the safety and tolerability of exposure to the oncolytic (‘cancer-killing’) virus coxsackievirus (CVA21), a naturally occurring strain of the common cold, in 15 patients with non-muscle invasive bladder cancer (NMIBC).

NMIBC is found in the tissue of the inner surface of the bladder and is the 10th most common cancer in the UK with approximately 10,000 people each year diagnosed with the illness.

During the study, 15 NMIBC patients, one week prior to pre scheduled surgery to remove their tumours, received CVA21 via a catheter in the bladder.

Examination of tissue samples post-surgery discovered that the virus was highly selective, targeting only cancerous cells in the organ and leaving all other cells intact.

According to the study, the virus was found to have infected cancerous cells and replicated itself causing the cells to rupture and die.

Urine samples taken from patients on alternate days detected ‘shedding’ from the virus indicating that once virally infected cancer cells had died, the newly replicated virus continued to attack more cancerous cells in the organ.

“Non-muscle invasive bladder cancer is a highly prevalent illness that requires an intrusive and often lengthy treatment plan. Current treatment is ineffective and toxic in a proportion of patients and there is an urgent need for new therapies,” said a professor.

“Coxsackievirus could help revolutionise treatment for this type of cancer. Reduction of tumour burden and increased cancer cell death was observed in all patients and removed all trace of the disease in one patient following just one week of treatment, showing its potential effectiveness. Notably, no significant side effects were observed in any patient,” the Prof. said.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                  https:// kneereplacement-stickclub.blogspot.com/                                                                      FOR CROCHET DESIGNS                                                                                                                                                                                     https://gscrochetdesigns.blogspot.com


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