Breast cancer treatments may increase risk of cardiac diseases

Treating breast cancer patients with chemotherapy and radiation may increase their risk of developing cardiovascular diseases, the doctors have warned.

With the advances in treatment, there has been a growing number of breast cancer survivors. However, survivors above the age of 65, were more likely to die from heart disease than breast cancer, the new study showed.

Targeted therapies for breast cancers like HER-2 could cause weakening of the heart muscle, a condition known as heart failure, it said.

Other therapies could also affect the heart arteries and cause the development of coronary artery disease or blockages, the study added.

Prompting attention to the fact that during treatment not only ones breast health, but also general health, including that of the heart, should be considered, the researchers suggested.

"Any patient who is going to undergo breast cancer treatment, whether they have heart disease at the beginning or not, should be aware of the potential effects of the treatments on their heart," said an Prof.

However, it should not deter or scare patients from undergoing the cancer treatment, instead allow them to make informed decisions with their doctor on the best option available, the Prof. added, in the statement published recently.

In some cases, post cessation of the treatment and/or the addition of heart medicines can improve heart function.

Administering Doxorubicin -- a chemotherapy drug -- used in breast cancer therapy can also lead to the damage of heart cells, but, giving the drug slowly, rather than all at once, may lower the risk of heart failure.

Doctors were also developing more-targeted radiation to reduce risks, the statement said.

Adherence to a number of ideal heart health behaviours including being physically active, achieving and maintaining a healthy body weight could help.

Besides, eating a healthy diet, avoiding tobacco, maintaining healthy levels of blood pressure, cholesterol and blood sugar may help prevent or minimise the damage.

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Treating breast cancer patients with chemotherapy and radiation may increase their risk of developing cardiovascular diseases, the American Heart Association has warned.

With the advances in treatment, there has been a growing number of breast cancer survivors. However, survivors above the age of 65, were more likely to die from heart disease than breast cancer, the new study showed.

Targeted therapies for breast cancers like HER-2 could cause weakening of the heart mus ..

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 A nanocarrier engineered to be small enough to get past the blood-brain barrier could be targeted to deliver a chemotherapeutic drug more efficiently to tumour cells in the brain, a new study reveals.

The blood-brain barrier is a protective barrier designed to keep a stable environment within and surrounding the brain. In experiments, the researchers found that the new method resulted in increased killing in the targeted cells.

"I was very surprised by how efficiently and well it worked once we got the nanocarrier to those cells," said Ann-Marie Broome from Medical University of South Carolina in the US.

The findings potentially point the way to a new treatment option for patients with certain conditions, such as glioblastoma multiforme (GBM), the focus of this study. 

 Glioblastoma multiforme is a devastating disease with no curative options due to several challenges, Broome said.
The brain tumour has a significant overall mortality, in part due to its location, difficulty of surgical treatment and the inability to get drugs through the blood-brain barrier.
In 40 percent of cases, standard treatments will extend life expectancy four to seven months. 

 That led the researchers engineer a micelle that is a phospholipid nanocarrier, "a bit of fat globule," to deliver a concentrated dose of the chemotherapy drug temozolomide (TMZ) to the deadly tumour cells.


"Micelles of a certain size will cross the blood-brain barrier carrying a concentrated amount of TMZ," Broome explained about how the nanotechnology works.

The study was published online in the international journal Nanomedicine - Future Medicine.

In medicine, Broome said, researchers construct nanocarriers that are stable and stealthy. "Your immune cells can't attack them. They remain hidden.

"When the package gets to where it's going, nanotechnologists have various methods to get the micelles to release their payloads -- one way is to use the acidic nature of a rapidly growing tumour," she said.