Treatment for liver disorder during pregnancy ineffective: Experts

A recent study found that the currently recommended treatment for a common pregnancy liver disorder that can result in preterm birth and still birth is ineffective and should be reconsidered.

In a paper published, it was found that 605 pregnant women with intrahepatic cholestasis of pregnancy (ICP), a liver disorder, were recruited with half receiving ursodeoxycholic acid (known as ‘urso’), the current drug used to treat the condition, and half a placebo. The researchers collected blood tests and samples, measured the women’s level of itching and recorded birth information.

The authors discovered that urso did not have an impact on pregnancy outcomes including preterm birth, neonatal unit admission, and stillbirth. They also got to know that it did not show any meaningful improvement in itch for most women, nor did it reduce the woman’s bile acid levels.
Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder affecting approximately 5,500 pregnancies annually in the UK. The condition causes the build-up of bile acids in the blood, and symptoms include itching, often severe. An increase in bile acid is associated with an increased risk of stillbirth, preterm birth, and neonatal unit admission.

Until now, urso hasn’t been tested in any large clinical trials to show whether it prevents premature birth and stillbirth.

“We want to find a safe and effective treatment for women with cholestasis of pregnancy so that we can prevent stillbirths in this condition. This trial has shown that the widely used drug ursodeoxycholic acid is not the answer. It is essential that we share these findings with pregnant women and clinicians so that we can avoid unnecessary medication in pregnancy. We now need to focus on finding a treatment that does work,” said the lead author of the study.

“The trial clearly demonstrates that for most women urso is not the drug to do this and while the outcome is likely to be hugely disappointing for women, it is also vital that they are not being falsely reassured. What we now urgently need is a drug treatment that can reduce both the itch and the risk of stillbirth that is associated with the condition and ICP Support will continue to work with researchers in their fight to do this,” said a researcher involved in the study.

Scientists are now looking to identify other potential treatments for women with this liver disorder. A clinical drug trial will be starting in early 2020 using rifampicin, an antibiotic that is also an effective treatment for itch outside pregnancy and improves removal of bile acids from the bloodstream.

“It is now clear that urso should not be used routinely to treat all women with ICP. Our future research focus will be to try to establish whether there is a subgroup of women who may still benefit from this drug, and also to focus on new drugs to improve outcomes for mothers and babies of ICP pregnancies,” added co-investigator of the study.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                  https:// kneereplacement-stickclub.blogspot.com/                                                                      FOR CROCHET DESIGNS                                                                                                    

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Walnut can prevent type 2 diabetes and many other diseases

Scientists are uprooting one or the other research every day in the university, public labs and government centres of research and development. According to the latest research,  a person who consumes 28 gms or four tablespoons of walnuts is less prone to type 2 diabetes.

Doubling walnut consumption (eating 3 tablespoons) was associated with a 47 per cent lower prevalence of type 2 diabetes, researchers said.

The study:

The university invited 34, 121 adults between the age group 18 and 85 years.
They were asked about their dietary intake, as well as if they had been diagnosed with diabetes or if they were taking medications for diabetes.
Individuals were also assessed for diabetes using common laboratory measurements including fasting plasma glucose and hemoglobin A1c.
"These findings provide more evidence for food-based guidance to help reduce the risk for diabetes," said a researcher.

Those adults who reported consuming walnuts showed a lower risk for type 2 diabetes compared to those who did not consume any nuts regardless of age, gender, race, education, BMI, and amount of physical activity.

"The strong connection we see in this study between walnut consumers and lower prevalence of type 2 diabetes is additional justification for including walnuts in the diet. Other research has shown that walnuts may also be beneficial for cognitive function and heart health," he said.

Walnut helps in lessening the risk of several diseases

Diabetic parents are vulnerable towards heart disease and stroke and walnut helps in combating cardiovascular diseases.

So, people who suffer from diabetes tends to have elevated blood pressure, cholesterol, or triglycerides which can be controlled to some extent with the consumption of walnut.

Among the numerous properties in walnuts that may be providing health benefits, walnuts are a rich source of recommended polyunsaturated fat (13 gms per 28 gms), which includes the plant-based omega-3 fatty acid alpha-linolenic acid (2.5 gms per 28 gms).

Findings from the new study  provide additional support for the role of walnuts as part of a healthy diet that may help reduce the risk for diabetes.

Few months ago, a study proved that a handful of walnuts a day may prevent not only heart disease but also bowel cancer.

Lead author said: 'Secondary bile acids have been shown to be higher in individuals with higher rates of colorectal cancer.

In a nutshell, this nut prevents the following diseases:

• Diabetes
• Bowel Cancer
• Heart Diseases

What is type 2 diabetes?

"Type 2 diabetes is a chronic disease. It is characterized by high levels of sugar in the blood. Type 2 diabetes is also called type 2 diabetes mellitus and adult-onset diabetes. However, more and more children and teens are developing this condition. Since type 2 diabetes is much more common than type 1 diabetes, it often is just called "diabetes"," defines a researcher.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                
 PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                                             FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                               
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Repeated Jet Lag May Increase Liver Cancer Risk

Repeated jet lag can increase both obesity related liver disease and the risk of liver cancer, researchers warned.

"Liver cancer is on the rise worldwide, and in human studies we have now seen that patients can progress from fatty liver disease to liver cancer without any middle steps such as cirrhosis," said lead author David Moore, Professor at Baylor College of Medicine in the US.

The study found that chronically jet-lagged mice developed liver cancer in a very similar way as that described for obese humans.
When we constantly travel through different time zones, work night shifts, or push ourselves to stay awake at the regular sleep time, our central circadian clock in the brain becomes chronically disrupted, the researchers said.

"We think most people would be surprised to hear that chronic jet lag was sufficient to induce liver cancer," Dr Moore added.

In the study, the researchers changed the times the lights went on and off during the night each week to understand the effects of chronic jet lag in normal mice who were fed a healthy diet.

They found that the mice gained weight and fat, and developed fatty liver disease, which progressed to chronic inflammation and eventually liver cancer in some cases.

The jetlagged mice lost normal control of liver metabolism. This included not only the buildup of fat, but also increased production of bile acids - acids produced by the liver to help us digest our food - linked with liver cancer.

Further, the jetlagged mice were also lacking in receptors - called FXR and CAR - that help regulate liver bile acid metabolism, which works in a similar manner in humans.

The researchers did not directly study jetlag in humans. But as evidence have showed that sleep disruption increases both fatty liver disease and liver cancer risk in humans, they hypothesised that lifestyle changes that generate chronic jet lag can also disrupt the body's internal homeostasis and increase liver cancer risk in humans.

The study appears in the journal Cancer Cell.

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HEALTH BENEFITS OF OKRA

Nutritional Information Okra contains vitamins A and C and is a good source of iron and calcium. It also contains starch, fat, ash, thiamine and riboflavin. No wonder, Cleopatra and Yang Guifei maintained their beauties. For 1/2 cup sliced, cooked okra For 1 cup raw okra Calories – 25Dietary Fiber – 2 gramsProtein – 1.52 gramsCarbohydrates – 5.76 gramsVitamin A – 460 IUVitamin C – 13.04 mgFolic acid – 36.5 microgramsCalcium – 50.4 mgIron – 0.4 mgPotassium – 256.6 mgMagnesium – 46 mg Calories – 33Fiber – 3.2gTotal Fat – 0.1gProtein – 2.0gCarbohydrate – 7.6gVitamin A – 660 IUVitamin C – 21mgFolate – 87.8mcgMagnesium – 57mg Health Benefits of Okra 1. The superior fiber found in okra helps to stabilize the blood sugar by curbing the rate at which sugar is absorbed from the intestinal tract. 2. Okra's mucilage binds cholesterol and bile acid carrying toxins dumped into it by the filtering liver. 3. Okra helps lubricate the large intestines due to its bulk laxative qualities. The okra fiber absorbs water and ensures bulk in stools. This helps prevent and improve constipation. Unlike harsh wheat bran, which can irritate or injure the intestinal tract, okra's mucilage soothes, and okra facilitates elimination more comfortably by its slippery characteristic. Okra binds excess cholesterol and toxins (in bile acids). These, if not evacuated, will cause numerous health problems. Okra also assures easy passage out of waste from the body. Okra is completely non-toxic, non-habit forming, has no adverse side effects, is full of nutrients, and is economically within reach of most individuals unlike over-the-counter drugs. 4. Okra fiber is excellent for feeding the good bacteria (probiotics). This contributes to the health of the intestinal tract. 5. Okra is a supreme vegetable for those feeling weak, exhausted, and suffering from depression. 6. Okra is used for healing ulcers and to keep joints limber. It helps to neutralize acids, being very alkaline, and provides a temporary protective coating for the digestive tract. 7. Okra treats lung inflammation, sore throat, and irritable bowel syndrome. 8. Okra has been used successfully in experimental blood plasma replacements. 9. Okra is good for summer heat treatment. 10. Okra is good for constipation. 11. Okra is good in normalizing the blood sugar and cholesterol level. 12. Okra is good for asthma. Okra's vitamin C is an antioxidant and anti-inflammatory, which curtail the development of asthma symptoms. 13. Okra is good for atherosclerosis. 14. Okra is believed to protect some forms of cancer expansion, especially colorectal cancer. 15. Eating okra helps to support the structure of capillaries. 16. Some information shows that eating okra lowers the risk of cataracts. 17. Okra is good for preventing diabetes. 18. Okra protects you from pimples and maintains smooth and beautiful skin. We understand the reason why Cleopatra and Yang Guifei loved to eat okra. There are other medicinal uses of okra, like its protection against trans fats. I myself planted about 25 stems of okra in my backyard garden throughout the year for over 20 years now. I can pick up about 20 pieces of okra pod every morning. All okra pods are consumed by my family. There are hundreds of recipes that can be done. You can either: cut it raw and mix with vinegar and pepper; cut it raw and mix with mayonnaise; steam, cut, with mayonnaise dressing; or, cook with stew or soup. Okra is easy to grow anywhere during summer season in cold countries and throughout the year in tropical areas. You can even plant it in a container garden at the terrace in condominium buildings. Inventor of PYRO-ENERGEN, the author, Mr. Takano himself picks up Okra in his backyard garden To tell you the truth, I did not know that okra seed was used as a substitute for coffee beans during World War II. I have about 500 grams of okra seeds, so I roasted one-half of it using an iron cast pan, and pulverized it. I made okra coffee with it, and it tasted like real coffee although it was darker in color. When I offered the okra coffee to my staffs and visitors who did not know the real thing, they replied "Oh, you got a new blend of coffee, taste is good". I blended it with real coffee, too. It tastes all right. We do not know, however, what nutrients okra coffee gives. About the Author: Junji Takano is a Japanese health researcher involved in investigating the cause of many dreadful diseases. In 1968, he invented PYRO-ENERGEN, the first electrostatic therapy device for electromedicine that effectively eradicates viral diseases, cancer, and diseases of unknown cause. **Benefit of eating Okra (Lady's Finger) * *A guy has been suffering from constipation for the past 20 years and recently from acid reflux. He didn't realize that the treatmentcould be so simple -- OKRA! (or Lady's Finger). He started eating okra within the last 2 months and since then have never taken medication again. All he did was consume 6 pieces of OKRA everyday. He's now regular and his blood sugar has dropped from 135 to 98, with his cholesterol and acid reflux also under control. Here are some facts on okra (from the research of Ms. Sylvia Zook, PH.D nutrition), University of Illinois . *  *"Okra is a powerhouse of valuable nutrients, nearly half of which is soluble fiber in the form of gums and pectins. Soluble fiber helps to lower serum cholesterol, reducing the risk of heart disease. The other half is insoluble fiber which helps to keep the intestinal tract healthy, decreasing the risk of some forms of cancer, especially colorectal cancer. * *Nearly 10% of the recommended levels of vitamin B6 and folic acid is also present in a half cup of cooked okra. Okra is a rich source of many nutrients, including fiber, vitamin B6 and folic acid. He got the following numbers from the University of Illinois Extension Okra Page Please check there for more details.  Okra Nutrition (half-cup cooked okra) * Calories = 25  * Dietary Fiber = 2 grams  * Protein = 1.5 grams  * Carbohydrates = 5.8 grams * Vitamin A = 460 IU  * Vitamin C = 13 mg * Folic acid = 36.5 micrograms  * Calcium = 50 mg  * Iron = 0.4 mg  * Potassium = 256 mg * Magnesium = 46 mg *  *These numbers should be used as a guideline only, and if you are on a medically-restricted diet please consult your physician and/or dietician. Ms Sylvia W. Zook, Ph.D. (nutritionist) has very kindly provided the following thought-provoking comments on the many benefits of this versatile vegetable. They are well worth reading 1. The superior fiber found in okra helps to stabilize blood sugar as it curbs the rate at which sugar is absorbed from the intestinal tract. 2. Okra's mucilage not only binds cholesterol but bile acid carrying toxins dumped into it by the filtering liver. But it doesn't stop there... 3. Many alternative health practitioners believe all diseases begin in the colon. The okra fiber, absorbing water and ensuring bulk in stools, helps prevent constipation . Fiber in general is helpful for this but okra is one of the best, along with ground flax seed and psyllium. Unlike harsh wheat bran, which can irritate or injure the intestinal tract, okra's mucilage soothes , and okra facilitates elimination more comfortably by its slippery characteristic many people abhor. In other words, this incredibly valuable vegetable not only binds excess cholesterol and toxins (in bile acids) which cause numerous health problems, if not evacuated, but also assures their easy passage from the body. The veggie is completely non-toxic, non-habit forming (except for the many who greatly enjoy eating it), has no adverse side effects, is full of nutrients, and is economically within reach of most. 4. Further contributing to the health of the intestinal tract, okra fiber(as  well as flax and psyllium) has no equal among fibers for feeding the good bacteria (probiotics).  5. To retain most of okra's nutrients and self-digesting enzymes, it should be cooked as little as possible, e.g. with low heat or lightly steamed. Some eat it raw. ................................................................................................................................................................. Some important benefits of consuming okra: Stabilises blood sugar level.  Lowers serum cholesterol level.  Prevents constipation.  Keeps intestinal tract healthy.  Feeds good bacteria residing in us all.

ps- this is only for information, but always consult you physician before having any particular food/ medication.

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