Wednesday, July 08, 2026

Sarcopenia Affects Nearly 1 in 5 with Rheumatoid Arthritis

NEARLY one in five people with rheumatoid arthritis also has sarcopenia, the progressive loss of muscle mass and strength, a study of almost a thousand patients finds, identifying who is most at risk and hinting that some biologic drugs may protect against it. 

Muscle Loss in Rheumatoid Arthritis 

People with rheumatoid arthritis (RA) are prone to sarcopenia, which erodes physical function and quality of life and may raise mortality. Chronic inflammation is thought to drive it, yet its prevalence under the latest diagnostic criteria was unclear. This study measured how common sarcopenia is in rheumatoid arthritis and which clinical factors mark it out. 

Study Design and Sarcopenia Assessment 

The cross-sectional study enrolled 978 patients with RA (mean age 60.1 years; 86.4% female) diagnosed by the 2010 ACR/EULAR criteria. Sarcopenia was defined using the Asian Working Group for Sarcopenia (AWGS) 2025 consensus, with bioelectrical impedance analysis measuring appendicular skeletal muscle mass and handgrip dynamometry gauging strength. Demographic details, clinical parameters, and medication use were recorded, and associations analysed by logistic regression. The observational design assessed patients at a single timepoint, with no intervention or follow-up. 

Risk Factors and Protective Drugs 

Sarcopenia affected 18.6% of patients (182 of 978). Male sex was strongly associated (odds ratio 9.140; 95% CI 5.211 to 16.029), as were longer disease duration (OR 1.046; 95% CI 1.025 to 1.069), higher RF-IgM level (OR 1.002; 95% CI 1.000 to 1.003), and higher prednisone dose (OR 1.094; 95% CI 1.033 to 1.159). Higher body mass index was protective (OR 0.586; 95% CI 0.534 to 0.643). Notably, use of tumour necrosis factor inhibitors (OR 0.502; 95% CI 0.312 to 0.808) and tocilizumab (OR 0.493; 95% CI 0.304 to 0.799) was each linked to lower odds of sarcopenia. 

Guiding Earlier Identification 

The authors concluded that sarcopenia is common in rheumatoid arthritis, with male sex, lower body mass index, longer disease, higher RF-IgM, and higher glucocorticoid use marking elevated risk. Tocilizumab and TNF inhibitors may reduce its incidence, hinting at a protective role worth further study. They advised the findings could help rheumatologists spot at-risk patients earlier, while cautioning that the small male subgroup (13.6%) limits how far the sex-related findings generalise. 

 

This is only for your information, kindly take the advice of your doctor for food, medicines, exercises and so on.   

 

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posted by G S Iyer at 9:16 AM 0 comments

Monday, May 04, 2026

Cardiologists Reveal 3 Things That Are Quietly Impacting Your Cholesterol

 Key Points

  • High cholesterol is impacted by modifiable variables like diet and nonmodifiable factors like genetics.
  • Inadequate amounts of quality sleep and chronic inflammation can lead to elevated cholesterol.
  • Regular testing, exercise, stress management and a heart-healthy diet are key for better cholesterol.

    • High cholesterol tends to fly under the radar, often building quietly without obvious symptoms. Over time, elevated levels can contribute to plaque buildup in the arteries, narrowing blood flow and increasing the risk of heart disease, heart attack and stroke. While most people think about diet when it comes to managing cholesterol, there are some underlying causes that can have a significant impact. From genetics to everyday habits like sleep, cardiologists share three surprising factors that may be quietly impacting your cholesterol levels and how you can change them.

    1. Genetics

    While your daily habits, like what you eat and how you move, can influence cholesterol levels, your genetics often set the baseline. In fact, cardiologists Bharat Sangani, M.D., and Nathaniel Lebowitz, M.D., both point to genetics as one of the most overlooked drivers of high cholesterol. Sangani shares that a key “genetic factor, particularly high lipoprotein(a) or Lp(a), is an inherited risk factor that is not included in a standard lipid panel. It can raise cardiovascular risk even when routine cholesterol numbers do not look especially high.”

    Lebowitz agrees, noting that “inherited conditions, like high Lp(a), can significantly raise your risk regardless of a healthy lifestyle.” He explains that Lp(a) is a particularly sticky type of cholesterol particle that promotes clotting and inflammation in the arteries and acts like glue for plaque. Because it typically doesn’t respond to diet or lifestyle changes, awareness and testing are especially important.

    2. Not Getting Enough Quality Sleep

    With never-ending to-do lists, getting enough quality sleep can feel like a challenge. But sleep is one habit worth prioritizing when managing cholesterol levels.

     Lebowitz explains that “many people don’t realize that a lack of quality rest can disrupt the hormones that regulate metabolism, leading to unfavorable changes in cholesterol.” He adds that poor sleep can raise stress hormones like cortisol and throw off appetite regulation, creating a ripple effect on blood lipid balance.

    Michelle Routhenstein, M.S., RD, CDCES, echoes this connection. “Having disrupted sleep or not enough sleep can lower HDL cholesterol and raise triglyceride levels,” she says, noting that elevated cortisol can increase low-density lipoprotein (LDL) cholesterol, promote abdominal weight gain and interfere with how your body clears cholesterol from the bloodstream.

    Current research shows that poor sleep quality is associated with higher concentrations of small dense LDL cholesterol. Those who reported getting less than eight hours of sleep nightly and poor-quality sleep experienced higher serum small dense LDL cholesterol concentrations than those who got adequate, quality sleep.

    3. Chronic Inflammation

    Chronic inflammation can quietly take a toll on your cholesterol health by negatively impacting your blood vessels. “Chronic inflammation, which can stem from other health conditions like autoimmune disorders, gum disease or chronic infections, can silently alter how your body manages cholesterol and increase the risk of plaque buildup in your arteries,” Lebowitz explains.

    Over time, this persistent inflammation can lead to subtle but meaningful damage, particularly to artery walls. It also shifts how your body processes fats. Lebowitz notes that this can cause LDL cholesterol to become more easily oxidized and incorporated into plaque, an important step in the development of atherosclerosis, which is artery-clogging buildup.

    Other Tips for Better Cholesterol

    • Get a complete lipid panel, including Lp(a) levels. The goal is prevention, not reaction. “Ask your doctor for a comprehensive assessment beyond the standard panel, including a one-time blood test for lipoprotein(a) and an apolipoprotein B (ApoB) level, especially if you have a family history of early heart disease,” Lebowitz explains.
    • Focus on foundational lifestyle factors like diet and exercise. “Diet quality, exercise, weight management, tobacco avoidance and sleep remain the first-line approach to managing cholesterol,” says Sangani. Start simply by adding fiber-rich foods to your diet that can support healthy cholesterol levels, such as oats, legumes, seeds and whole grains. For fitness, aim for 150 minutes of moderate-intensity aerobic activity, like dancing or brisk walking, per week. It is also important to add at least two strength-training sessions, like lifting weights or Pilates.
    • Practice stress management. Routhenstein suggests finding a stress-management routine that fits into your daily routine. “Build stress resiliency by bringing joy, mindfulness and downtime into your life to help your body manage fight-or-flight responses,” she explains.

    Our Expert Take

    Managing your cholesterol is a key part of protecting your long-term heart health. While nutrition and physical activity are foundational, they’re only part of the picture. Factors like genetics, sleep quality and chronic inflammation can quietly influence your cholesterol levels over time. By staying informed about your numbers, prioritizing consistent, restorative sleep and maintaining a balanced lifestyle that includes nourishing foods and regular movement, you can take meaningful steps toward better cholesterol control.

     

    This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

     

     





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    posted by G S Iyer at 1:40 AM 0 comments