Wednesday, June 09, 2021

4 Ways Exercise Helps Fight Aging

Everyone knows that exercise is good for you. But it’s not just beneficial for the young, healthy and already fit. It’s also one of the best defenses against the toughest aspects of aging.

Exercise not only improves heart and lung health, but research shows that even modest physical activity is good for the brain, bones, muscles and mood. Numerous studies have found that lifelong exercise may keep people healthier for longer; delay the onset of 40 chronic conditions or diseases; stave off cognitive decline; reduce the risk of falls; alleviate depression, stress and anxiety; and may even help people live longer.

“Exercise is the best defense and repair strategy that we have to counter different drivers of aging,” says aging researcher Nathan LeBrasseur, professor of physical medicine and rehabilitation at the Mayo Clinic in Rochester, Minn. It can’t reverse aging, per se, he cautions, but “there’s clear evidence that exercise can activate the machinery necessary for DNA repair.”

Of course, the sooner you begin and the longer you remain physically active, the better. But physical activity is important at every age. Research on the effects of exercise on nursing-home residents found improvements in their physical and cognitive abilities as well as on their mental health.

Something else to keep in mind, says LeBrasseur, is that while your risk for developing Alzheimer’s disease, cardiovascular disease, Type 2 diabetes, cancer or other conditions of aging may not substantially increase until middle age or later, the underlying biology for those conditions is in motion early in life. Genetics and the lifestyle factors you choose will determine that trajectory, but these can influence your likelihood for disease at any point. “So, there’s no such thing as too little, too late.”

The good news is that you don’t have to run a marathon or go to the gym to reap the anti-aging benefits of exercise. Even modest physical activity—taking the stairs instead of the elevator, gardening or walking the dog—has physical and cognitive benefits, as long as you do it regularly. Here are just some of the ways research shows regular activity benefits your health.

It builds muscle strength

As people age, they lose muscle mass and strength, a condition known as sarcopenia. Scientists say resistance training is one of the best ways to help slow that decline. It not only maintains muscle strength and power (what you’ll need while opening a jar or pushing a heavy door), but it makes everyday activities like cooking, cleaning and climbing stairs less difficult. It can also help reduce susceptibility to disease, improve brain health and mood and help you maintain independence longer. Researchers at the University of Alabama found that resistance training is safe and effective for older adults, with rates of injuries extremely low and similar across all ages and intensities.

It improves bone density

To keep bones strong, the body breaks down old bone and replaces it with new bone tissue—but around age 30, bone mass stops increasing. In your 40s and 50s, you slowly start losing more bone than you make. Exercise can help increase bone density when you’re younger and stave off osteoporosis, a disease that weakens bone and increases the risk of breaks as you age.

Almost half of all adults 50 and older are at risk of breaking a bone due to osteoporosis, which costs the health system $19 billion annually, according to the National Osteoporosis Foundation. But that doesn’t mean that older people are powerless; doing weight-bearing exercise throughout life helps increase bone mass and strength.

Since osteoporosis affects women more often than men, activities like walking or aerobics are especially important after menopause. While older people can’t gain more bone mass, physical activity can help prevent bone loss. Lower impact activities like cycling, yoga and swimming aren’t enough to affect bone loss, but when combined with weight-bearing exercises, they can help improve balance and reduce risk of falls and fractures.

Exercise can lengthen telomeres

Telomeres are the caps on the ends of DNA strands, similar to the caps on shoelaces. Their length decreases with aging, and this contributes to cell senescence, meaning the cells can no longer divide. Telomere length is connected to certain chronic conditions, especially high blood pressure, stroke and heart disease. Several studies have found that higher levels of physical activity are related to longer telomere lengths in some people, compared to those who are sedentary. This seems to be especially true in older people. However, it’s still not clear whether that relationship is causal, and it’s likely that multiple processes affect telomere length. But in general, longer telomeres are believed to be a plus for reducing risk of age-related diseases.

It can improve cognition

Your ability to shift quickly between tasks, plan an activity and ignore irrelevant information are all signs of good cognitive function, according to the National Institute on Aging. Physical activity is now seen as one of the most promising methods for improving cognition throughout life and reducing risk of age-related cognitive decline. While researchers can’t yet say for sure that exercise can actually prevent dementia, studies show that more physical activity is linked to reduced risk of dementia, including Alzheimer’s disease.

As scientists continue to research the effects of exercise, they’re finding all kinds of exciting benefits, says Steven Austad, senior scientific director at the American Federation for Aging Research and chair in the department of biology at the University of Alabama at Birmingham. For example, “exercising muscle produces myokines, which are small molecules that have all kinds of benefits in your brain,” he says. ”It’s also one way to really improve the quality of your sleep, and we know that the quality of your sleep is related to the quality of your health.”

There’s still a lot we don’t know about how exercise affects the aging process, but what we do know is this: moving your body regularly—five times per week, for at least 30 minutes daily—is better than moving less often. Exercise is cumulative; you don’t have to do it all at once (and of course, check with your health provider before starting any new activity). And a combination of aerobic and resistance exercises seems to provide the most benefits for most people.

Best of all, it’s never too late to start.

 

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

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Tuesday, January 07, 2020

Researchers study new immunogenic properties of already existing anti-cancer drugs

The world scientific community is waging a difficult and prolonged war on cancer. New research in the field of immunogenic cell death can extend the area of drugs application and ensure patients' protection from relapse after therapy.

Cancer treatment is not just the removal of the tumor cells from the body, and chemotherapy. The doctors' aim is to provide a scenario that would prevent tumor cells from proliferating and causing a new disease.

For many years, scientists at the Lobachevsky State University of Nizhny Novgorod and the University of Ghent (Belgium) have been engaged in research aimed to minimize the harm to the body after cancer treatment and have been looking for new approaches to treating cancer patients. 

The project, supported by a grant from the Russian Science Foundation and headed by Dmitry Krys'ko, leading researcher of the Lobachevsky University's Institute of Biology and Biomedicine, professor at Ghent University, has yielded its first major results.

According to Professor Dmitry Krys'ko, the existing anti-cancer therapy (chemotherapy, radiation therapy and photodynamic therapy) causes great damage to the body as a whole, while his team's research is aimed at the stimulation of immunogenic cell death, which not only minimizes the damage, but also enhances the efficacy of treatment by involving the body's resources in the fight against cancer.

In this study, we tested some drugs for anticancer therapy based on photodynamic treatment and investigated their new immunogenic properties. We can say that not only the external impact will be used to fight cancer, but also the body itself will engage in the fight by triggering the reactions of the adaptive immune response.

The concept of immunogenic cell death (ICD) includes a programmed death of cancer cells with subsequent release of molecules that give a danger signal to the immune system. We tested the drugs that are already used in cancer therapy, and enhanced the action of these agents."

Dmitry Krys'ko, leading researcher of the Lobachevsky University's Institute of Biology and Biomedicine, professor at Ghent University

The study employed a number of methods and approaches that were used in in vitro and in vivo experiments. At the laboratories of Lobachevsky University and the University of Ghent, researchers studied how substances accumulate in the cell, analyzed cell death types when cells were exposed to photosensitizers, and revealed molecular mechanisms of the phenomena that occur to the cells in the process of their death.

"In this study, we examined the cellular-level response of dendritic cells (immune system components) in their interaction with cancer cells that were exposed to photodynamic therapy (PDT) and proved that photodynamic therapy can activate the body's own immune response," said Victoria Turubanova, research assistant of the Department of General and Medical Genetics at the UNN Institute of Biology and Biomedicine.

The researchers have examined additional aspects of the use of existing drugs for developing new cancer protocols based on the stimulation of the immune system. Such variants of therapy reduce the risk of metastasis and enhance the effectiveness of the patient's recovery.

A series of experiments on laboratory mice was performed, resulting in an important conclusion that the cellular vaccine prepared from dying cancer cells protects the mouse from cancer by preventing tumor development in the body.

Based on the results obtained, the researchers have published their article "Immunogenic cell death induced by a new photodynamic therapy based on Photosens and Photodithazine" in the BMC Journal for ImmunoTherapy of Cancer (with the impact factor of 8.67), which describes new variants of photosensitizers that cause immunogenic cell death of cancer cells.

this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     
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Saturday, September 14, 2019

Tiny bubbles in our body to fight cancer better than chemo

Researchers have found that tiny bubbles in our body might potentially be used to treat cancer and could fight the disease better than chemotherapy.

Healthy cells in our body release nano-sized bubbles that transfer genetic material such as DNA and RNA to other cells. It's your DNA that stores the important information necessary for RNA to produce proteins and make sure they act accordingly.

According to the researchers, these bubbly extracellular vesicles (EV) could become mini treatment transporters, carrying a combination of therapeutic drugs and genes that target cancer cells and kill them.

"What we've done is improve a therapeutic approach to delivering enzyme-producing genes that can convert certain drugs into toxic agents and target tumours," said the study's lead author .


These drugs or prodrugs start out as inactive compounds. But once they metabolize in the body, they are immediately activated and can get to work on fighting everything from cancer to headaches.

Aspirin is an example of a common prodrug.

In this case, researchers used EVs, to deliver the enzyme-producing genes that could activate a prodrug combination therapy of ganciclovir and CB1954 in breast cancer cells.

Minicircle DNA and regular plasmid - two different gene vectors that act as additional delivery mechanisms for DNA - were loaded into the vesicles to see which was better at helping transport treatment.

This is known as a gene-directed enzyme, prodrug therapy.

They found that the minicircle DNA was 14 times more effective at delivery and even more successful at killing cancerous tumours.

"Conventional chemotherapy isn't able to differentiate between tumours and normal tissue, so it attacks it all," he said.

With EVs, treatment can be targeted and because of their compatibility with the human body, this type of delivery could minimize the risk of unwanted immune responses that can come with other gene therapies.

"If EVs prove to be effective in humans, it would be an ideal platform for gene delivery and it could be used in humans sooner than we expect," he added.


this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   
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https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
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Sunday, June 16, 2019

Immune system of new born is transferred from mothers

To help the newborn immune system learn to discriminate between friend and foe, mothers transfer antibodies to their infants via the placenta, recent findings suggest.

As part of a recent study, a team of researchers has determined how a pregnant woman's vaccine-induced immunity is transferred to her child, which has implications for the development of more effective maternal vaccines.
 
"Newborns arrive into the world on the first day of life with brand-new immune systems that, like the children themselves, need to learn to cope with both helpful and harmful microbes in their environment," explained  co-senior author of the study.

According to the researchers, to help the newborn immune system learn to discriminate between friend and foe, mothers transfer antibodies to their infants via the placenta.

The rules by which the placenta performs this absolutely essential function have been unknown but if decoded, could hold the key to generating more powerful vaccines to protect these most precious patients.

While maternal antibodies against some diseases such as measles can be transferred from mother to infant, providing some protection until the child is old enough for individual vaccination, antibodies to other serious diseases like polio are less efficiently transferred.

To investigate the mechanisms by which antibodies are transferred from mother to child, the team of researchers used a novel tool called system serology to compare the quantity and quality of antibodies against pertussis in blood samples from mothers and from the umbilical cords that carry blood, nutrients and immune factors from the placenta to the infant.

Their investigation revealed that the placenta preferentially sifts out and delivers to the infant antibodies that activate natural killer (NK) cells, key elements of the innate immune system. While several important immune cells are too immature in newborns to provide effective protection, NK cells are among the most abundant and functional immune cells during the first days of life.

The team found a similar preference for the placental transfer of NK-activating antibodies against influenza and respiratory syncytial virus, a common disease of childhood, and also identified antibody features that appear to regulate placental selection, features that could possibly be built into next-generation vaccines with improved mother-to-child antibody transfer.

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Friday, January 04, 2019

This Green Veggie Treats Alcohol and Mood Disorders

A large protein found in spinach may aid in the development of new medications for millions around the world dealing with alcohol use disorders, chronic pain, and mood disorders, researchers said. The study, discovered two peptides which are naturally metabolic products of Rubisco — a large protein found in many plants like spinach, which will aid within the development of latest medications. “These disorders are presently not adequately managed,”according to the Prof.

“Better medications that take an additional holistic approach and manufacture fewer aspect effects are going to be helpful. “We discovered that these peptides by selection activate the identified helpful pathways while not activating the ‘side-effect pathways’ of the receptor,” the Prof. added.

The discovery, aims to develop molecules that only activate the cellular signaling pathways associated with their therapeutic effect. Pre-clinical studies suggest that the peptides are orally bio-available and able to penetrate the blood-brain barrier, both of which are necessary for a drug to effectively treat a disorder of the central nervous system, he said.

The researchers are actively pursuing synthetic and computational strategies to improve these peptides to make them more effective. The rubiscolin peptides are also being investigated for their ability to regulate dietary intake and are even commercially available in anti-aging skin products.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                
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Sunday, April 08, 2018

There's a Link Between Autism And Epilepsy, And Scientists Might Have Figured It Out

Researchers have discovered why a mutated gene causes seizures in some children who have autism.
Autism spectrum disorder is a highly prevalent neurodevelopmental disorder - affecting one in 68 children - characterized by a range of symptoms, including difficulty with communication and social interactions.

One third of children who have autism spectrum disorder also have epilepsy. It's related to a gene that is mutated in patients with autism. But scientists didn't know why the mutation causes seizures.
The new discovery shows the mutation acts like a bad gardener in the brain.

It shrinks the neurons' tiny branches and leaves - its dendrite arbors and synapses - that let brain cells relay vital messages and control the brain's activity.

That shrinkage can cause a breakdown in message delivery.

In people with the mutation, inhibitory neurons- that are supposed to keep things tranquil in the brain and slam the brake on excitatory neurons - don't grow enough branches and leaves to communicate their calming message, according to the research. That can lead to seizures.

The mutation, CNTNAP2 or "catnap2," works as a team with another mutated gene, CASK, implicated in intellectual disability. As a result, scientists now have a new target for drugs to treat the disorder.

"Now we can start testing drugs to treat the seizures as well as other problems in autism," says lead author, professor of psychiatry and behavioral sciences.

"Patients with the mutation also have language delay and intellectual disability. So a drug targeting the mutation could have multiple benefits."

Next, researchers will do high-throughput screening of molecules with the goal of reversing these abnormalities in patients with autism.

Catnap2 is an adhesive molecule that helps cells stick together, in this case helping the synapses adhere to the dendrites. It's a difficult molecule to target with drugs, the author says.

But catnap2's partner, CASK, is a social butterfly enzyme that interacts with many other molecules.
Drugs can more easily inhibit or activate the enzyme, so researchers will screen drugs to activate it, because that appears to maintain healthy dendrite branches.

When scientists blocked CASK in the study, dendrites didn't grow.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                                                                                                                                      PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/   
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