Drug designed to treat impotence can treat heart failure

A drug used to treat erectile dysfunction (inability to get and keep an erection firm to have sexual intercourse) can slow down or even reverse the progression of heart failure, claim researchers.

According to the study, most current treatments are ineffective. However, the current study conducted on a sheep is claimed to be a breakthrough in the treatment of heart disease.

The lead author argues the effect is likely to be shown in humans as well. Heart failure is a devastating condition, occurring when the heart is too weak to pump enough blood to meet the body’s needs. It also causes a build-up of fluid that backs up into the lungs, resulting in breathlessness as well as fluid retention, resulting in swelling of different parts of the body.

“This discovery is an important advance in a devastating condition which causes misery for thousands of people across the UK and beyond,” said the Professor.

We do have limited evidence from human trials and epidemiological studies that show Tadalafil can be effective in treating heart failure.

This study provides further confirmation, adds mechanistic details and demonstrates that Tadalafil could now be a possible therapy for heart failure.

It’s entirely possible that some patients taking it for erectile dysfunction have also unwittingly enjoyed a protective effect on their heart.

When the animals had heart failure – induced by pacemakers – which was sufficiently advanced to need treatment, the team administered the drug.

Within a short period, the progressive worsening of the heart failure was stopped and, importantly the drug reversed the effects of heart failure.

And the biological cause of breathlessness in heart failure- the inability of the heart to respond to adrenaline was almost completely reversed.

The dose the sheep received was similar to the dose humans are given when being treated for erectile dysfunction.

Tadalafil blocks an enzyme called Phosphodiesterase 5 or PDE5S for short, which regulates how our tissue responds to hormones like adrenaline.

The research team found that in heart failure, the drug altered the signalling cascade – a series of chemical reactions in the body – to restore the heart’s ability to respond to adrenaline.

And that increases the ability of the heart to force blood around the body when working harder.

The Prof. added, “This is a widely used and very safe drug with minimal side-effects. However, we would not advise the public to treat themselves with the drug and should always speak to their doctor if they have any concerns or questions.Tadalafil is only suitable as a treatment for systolic heart failure – when the heart is not able to pump properly – and there may be interactions with other drugs patients are taking.”

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Why heart failure is not as life-threatening as a heart attack

Heart failure may be a serious health hazard but not life-threatening like a heart attack, health experts say.

"Heart failure refers to the heart's inability to circulate blood through the body. Blood flow is slower than normal, which compromises the blood flow to the vital organs of the body like kidneys, liver and brain, leading to the malfunction of these organs," Subhash Chandra, Chairman, Cardiology, BLK Super Speciality Hospital, New Delhi, told IANS.

Heart failure is not similar to a heart attack and it is important for people to understand the difference, the experts said.

"Heart failure refers to the condition wherein the blood pumping capacity of the heart is reduced. Heart attack is secondary to blocked coronary circulation. Blood supply to muscles of heart is cut or drastically reduced," Salil Shirodkar, Interventional Cardiologist at Mumbai's Nanavati Super Speciality Hospital, told IANS.

According to the experts, two types of heart dysfunctions can lead to heart failure -- systolic heart failure and diastolic failure.

Systolic heart failure is the most common cause of heart failure and occurs when the heart is weak and enlarged and the muscle of the left ventricle loses some of its ability to contract or shorten, whereas diastolic failure is when the muscle becomes stiff and loses some of its ability to relax.

As a result, the affected chamber has trouble filling with blood during the rest period that occurs after each heartbeat.

Heart failure is caused by many conditions that damage the heart muscle, including coronary artery disease (CAD), heart attack, cardiomyopathy -- disease of a heart muscle.

"The main causes of heart failure are blockages in the blood vessels supplying blood to the heart leading to heart attacks, weakness of the heart muscles either because of unknown reasons or because of some infection, drugs, diabetes, etc.; high blood pressure  is also one of the main causes of heart failure," Vishal Rastogi, Head of Department, Heart Failure Clinic, Fortis Escorts Heart Institute, told IANS.



Heart failure can also occur with heart defects present at birth or congenital heart defects.

"Children with congenital heart defects often have slower growth and development and they may be smaller than other children of the same age. They may also have life-long problems with learning difficulties," Shantala Vadeyar, Group Medical Director, Department of Fetal and Maternal Medicine, Cloudnine Group of Hospitals, Mumbai, told IANS.

Early symptoms of heart failure are fatigue and shortness of breath. These affect daily activities such as walking, climbing stairs or carrying groceries.

The warning signs associated with heart failure includes acute shortness of breath, coughing or wheezing, accumulation of excess fluid in body tissues, tiredness, fatigue, nausea, lack of appetite and an   elevated heart rate.

"Basically your heart tries to compensate for its lack of strength by beating more often to help deliver a sufficient amount of blood to your tissues and organs," Chandra explained.

However, heart failure can be prevented by having proper diet, daily exercise, swimming, jogging, adequate sleep, and minimising stress and tension.

Diabetic or hypertensive patients should be more careful; they should always take the medications as prescried by the doctor.

"As of now there's no known cure for heart failure, but there are steps that can be taken to prevent a weak heart from getting weaker," Chandra said.

"Controlling hypertension, regular medical follow-up with doctors, non-smoking and alcohol consumption in moderation and lifestyle modifications with an effective mix and match of diet, along with daily exercise, are the key to preventing heart failure," Shirodkar added.

For children with congenital heart defects, it is not all bad news, as some of these defects may be treatable.

"Many congenital heart defects (CHD) can also be treated and children can lead a normal life. It is important that CHD should be detected in the developing baby so that doctors can counsel parents to help them prepare for possible outcomes and surgical interventions," Vadeyar said.

Surgery may also sometimes prevent further damage to the heart and improve its functioning.

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Heart failure may be a serious health hazard but not life-threatening like a heart attack, health experts say.

"Heart failure refers to the heart's inability to circulate blood through the body. Blood flow is slower than normal, which compromises the blood flow to the vital organs of the body like kidneys, liver and brain, leading to the malfunction of these organs," Subhash Chandra, Chairman, Cardiology, BLK Super Speciality Hospital, New Delhi, told IANS.

Heart failur ..

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