Skin cells help activate hair re-growth

A new study has provided a deeper insight into how to activate hair re-growth with the help of skin cells.

A group from the Spanish National Cancer Research Centre (CNIO) has discovered an unexpected link between the body's defense system and skin regeneration. It turns out that macrophages are involved. These are cells from the immune system that are in charge of devouring invading pathogens, a process called phagocytosis.

The authors report that macrophages induce hair growth by surrounding and activating cells in the skin that have regenerative capacity, called stem cells. The discovery that macrophages activate skin stem cells could influence technologies with potential applications in tissue regeneration, aging, and cancer.

Donatello Castellana, from the Epithelial Cell Biology Group of the BBVA Foundation-CNIO Cancer Cell Biology Programme, said that the researchers used tiny droplets, or liposomes, to carry the drug used in the study. The future use of liposomes as a way to deliver a drug to specific cells looks promising and might have additional implications for the study of several pathologies.

The study is published in the journal PLOS Biology. 


THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.








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Paralyzed Man Walks Again Thanks to Nose

In 2010, Darek Fidyka was attacked and stabbed multiple times. The attacker severed his spine, rendering him paralyzed from the chest down, but now, thanks to a new and revolutionary procedure, Darek can walk again!

The operation involved taking special cells from the patient’s nose, called “Olfactory Bulbs”. These bulbs are the only part of the human body able to regrow nerves, due to the nose’ constant exposure to chemicals that might damage it. Without such an ability, humans would lose their sense of smell very early in life. The idea of harnessing that ability and applying it to other major nerve centers has been discussed by doctors at length, and tests have shown that paralyzed rats and dogs regained their mobility thanks to such treatment.

After 2 years in a wheelchair, Darek was selected and went through this surgery, which involved 100 microinjections into the injured area. After the procedure, Darek went through physical therapy five times a day, but showed no response. At the third month, though, he noticed that he’s gaining muscle again in his legs. By the sixth month, Darek was able to take a few steps on his own, and now he is able to walk with a walking frame. Darek reports that he also started gaining some control over his bowels, bladder and even some sexual control.

Darek was quoted saying: “I think it's realistic that one day I will become independent.” This story brings much hope to hundreds of thousands of paralyzed men, women and children who might be able to walk again, and sooner than they think!  THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES. PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG- HTTP:GSEASYRECIPES.BLOGSPOT.COM/ FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG- HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/ FOR CROCHET DESIGNS HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM

BYPASS SURGERY MAY SOON BECOME A THING OF THE PAST

Source: Biochemical   Pharmacology 

Bypass  Surgery Might Be History  Soon...

In a groundbreaking discovery  that may eventually render bypass surgery history,  researchers at Tel Aviv University  have shown that an injected protein  can  regrow blood vessels in the human  heart.

 In heart disease, blood vessels  are either clogged or die off, starving the heart of  oxygen and leaving it highly
 susceptible to a cardiac  attack.

Dr. Britta Hardy of TAU's  Sackler School of Medicine and her team of researchers  have developed a protein-based  injection that when delivered straight to muscles  in the body, sparks the regrowth  of tiny blood  vessels.

 The new vessels in the heart could  give millions of people  around   the world a new lease on  life.

 "The biotechnology behind our human-based protein therapy is very complicated,  but the goal is simple and the> solution is straightforward. We intend to inject  our drug locally to heal  any oxyinflammation   gen-starved  tissue.

 So far in animal models, we've  seen no side effects and  no following our injection of the drug into the legs. The growth of new  blood   vessels happens within a few  weeks, showing improved blood  circulation,"
said  Hardy.
 The protein solution can also be  added as a coating to a  stent. Usually, the the implantation of a stent is
accompanied by a high risk for blood  clots,   which necessitates the use of  blood  thinners.

"We could coat a stent with > our peptide, attracting endothelial stem cells  to  form a film on the surface of the
 stent. These endothelial cells on the stent  would eliminate the need for  taking the blood thinners that prevent
blood   clots from forming," said  Hardy.

 If investment goals are met, the  researchers are hoping that toxicity studies and  Phase I trials could be complete

within two years.

The researchers began the study  for preventing leg amputations, positing  that  proteins from the human body could  be used to trigger the growth of new blood  vessels.

Hardy started by studying a  later confirmed initial  library of peptides and testing them in the laboratory  synthesized peptides and tested  them in diabetic mice whose> results. She then took some of the isolated and  legs were in the process of  dying.

 Although diabetes is known to  decrease blood circulation, Hardy found  that  her therapy reversed the decrease.
 "Within a short time we saw the  formation   of capillaries and tiny blood vessels.

After three weeks, they had grown  and merged together with the rest of  the   circulatory system," she  said. In mice with limited blood circulation, she  was   able to completely restore blood  vessels and save their  legs.

 It was then a short step to  studying the applicability of the research  to cardiac patients.  "It''s pretty obvious if there is regrowth or  not.

 Our technology promises to regrow  blood vessels like a net, and a heart that   grows more blood vessels becomes  stronger. It's now imaginable that, in  the   distant future, peptide injections may be able to replace bypass  surgeries,"   concluded  Hardy. 

ps- this is only for information, always consult you physician before having any particular food/ medication/exercise/other remedies.

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