BYPASS SURGERY MAY SOON BECOME A THING OF THE PAST

Source: Biochemical   Pharmacology 

Bypass  Surgery Might Be History  Soon...

In a groundbreaking discovery  that may eventually render bypass surgery history,  researchers at Tel Aviv University  have shown that an injected protein  can  regrow blood vessels in the human  heart.

 In heart disease, blood vessels  are either clogged or die off, starving the heart of  oxygen and leaving it highly
 susceptible to a cardiac  attack.

Dr. Britta Hardy of TAU's  Sackler School of Medicine and her team of researchers  have developed a protein-based  injection that when delivered straight to muscles  in the body, sparks the regrowth  of tiny blood  vessels.

 The new vessels in the heart could  give millions of people  around   the world a new lease on  life.

 "The biotechnology behind our human-based protein therapy is very complicated,  but the goal is simple and the> solution is straightforward. We intend to inject  our drug locally to heal  any oxyinflammation   gen-starved  tissue.

 So far in animal models, we've  seen no side effects and  no following our injection of the drug into the legs. The growth of new  blood   vessels happens within a few  weeks, showing improved blood  circulation,"
said  Hardy.
 The protein solution can also be  added as a coating to a  stent. Usually, the the implantation of a stent is
accompanied by a high risk for blood  clots,   which necessitates the use of  blood  thinners.

"We could coat a stent with > our peptide, attracting endothelial stem cells  to  form a film on the surface of the
 stent. These endothelial cells on the stent  would eliminate the need for  taking the blood thinners that prevent
blood   clots from forming," said  Hardy.

 If investment goals are met, the  researchers are hoping that toxicity studies and  Phase I trials could be complete

within two years.

The researchers began the study  for preventing leg amputations, positing  that  proteins from the human body could  be used to trigger the growth of new blood  vessels.

Hardy started by studying a  later confirmed initial  library of peptides and testing them in the laboratory  synthesized peptides and tested  them in diabetic mice whose> results. She then took some of the isolated and  legs were in the process of  dying.

 Although diabetes is known to  decrease blood circulation, Hardy found  that  her therapy reversed the decrease.
 "Within a short time we saw the  formation   of capillaries and tiny blood vessels.

After three weeks, they had grown  and merged together with the rest of  the   circulatory system," she  said. In mice with limited blood circulation, she  was   able to completely restore blood  vessels and save their  legs.

 It was then a short step to  studying the applicability of the research  to cardiac patients.  "It''s pretty obvious if there is regrowth or  not.

 Our technology promises to regrow  blood vessels like a net, and a heart that   grows more blood vessels becomes  stronger. It's now imaginable that, in  the   distant future, peptide injections may be able to replace bypass  surgeries,"   concluded  Hardy. 

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