Lymphatic disorder may cause stillbirth, chronic disease in affected children

In a breakthrough discovery, South Australian researchers have identified a genetic mutation responsible for a lymphatic disorder that may be responsible for causing stillbirth or severe, chronic disease in affected children.

The findings were published in the journal 'Science Translational Medicine'.

An anomaly in the development of lymphatic vessels in unborn children, leading to fluid accumulating in the heart, lungs, and other organs, was uncovered by the scientists from the Centre for Cancer Biology (CCB) based at the University of South Australia (UniSA) and SA Pathology.

CCB Director Professor Natasha Harvey said a genetic study of six families affected by stillbirth or lymphoedema revealed the link between a mutated protein-coding gene called MDFIC and fluid accumulation in vital organs and tissues.

This demonstrated that MFDIC is important for controlling the growth and development of the lymphatic vessels in the foetus for the first time.

"The lymphatic system is a network of vessels (pipes) and nodes (filters and control centres) important for maintaining fluid balance in our tissues and transporting infection-fighting white blood cells throughout our bodies," Prof Harvey said.

"We determined that MDFIC controls cell migration, an important early event during the formation of the lymphatic vessel valves. The genetic variants we have found in our study reveal a crucial, previously unrecognized role for MDFIC in the lymphatic vasculature."

"If the lymphatic valves don't form properly, lymph fluid accumulates in critical organs such as the heart and lungs, causing major respiratory problems that may eventuate in stillbirth or chronic disease."

An SA Pathology research team headed by Professor Hamish Scott initially found the genetic link in an Australian family. Their international colleagues in Belgium, Germany, and the US reported variants in the same gene, MDFIC, in several patients with the same lymphatic disorder.

Prof Harvey said, the disorder, known as the central conducting lymphatic anomaly (CCLA), is one of a group of severe lymphatic disorders and may result in stillbirth, or severe chronic disease in affected children.

Few effective treatments are available but with continued identification of the genetic causes of CCLAs, Prof Harvey says the next step is to develop new therapeutic drugs to combat the disease.

"There are existing drugs that may be used to treat these disorders, but we need to make sure that the signalling pathway that's treated by those drugs is the same pathway that is affected in our patients.

"This project is about the power of collaboration at a local level, national level, and international level, so that's been really important. Science is done in teams and we have great research teams here in Adelaide at the Centre for Cancer Biology. Our Ph.D. students and postdoctoral fellows have been integral to this work. They have really driven it and we're delighted to be working with such a group of talented people."

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement

 

What Foods You Should or Shouldn't Eat

You are what you eat. There's a reason that saying is an old classic. Studies today show that our microbiome, or in other words the bacteria that make up about half our body - influences us much more than do our genes. They have a lot to say about whether we get sick, how we feel and develop, how much risk we have of age-related diseases and even our daily mood. Most of these come from the foods we eat.

Besides, these foods build our bodies, and the wrong foods can create the wrong body for us. Below you'll find some of our best posts about the wrong and the right foods for you, do some homework and maybe you'll discover some combinations you can hope to adopt or stop using.

10 Foods That Resemble the Organs They Help
You are what you eat, but as it turns out, there is a larger similarity between the human body and food than we initially thought. We found 10 foods that look a lot like the body part they actually help. A coincidence? Maybe, but it doesn't take away from this handy advice!

1. Carrot - Eyes
If you slice a carrot, you will easily identify the similarities between this vegetable and the eye. Indeed, the carrot is wonderful for the eyes; it's rich in vitamins and antioxidants such as beta carotene, which diminish the risk of ocular degeneration, the number one reason for loss of sight among adults.

2. Walnut - Brain
The folds, wrinkles and shape of the walnut are reminiscent of that of the brain, and it's little wonder that walnuts are called "brain food". Walnuts are full of linoleic alpha acid, an Omega 3 fatty acid, which is essential to the biological process of the body. The amino acid plays an important role in building brain cells and keeping them functioning properly.

3. Celery - Bones
The long and thin stems of the celery not only look like bones, they help them too. Celery is an excellent source of silicon, which is part of the molecular structure that gives bones their enormous strength. An interesting coincidence is that bones contain 23% sodium, and so does celery.

4. Avocado - Womb

It looks like a womb and it is great for fertility. The avocado is a great source of folic acid, which has been found to reduce the risk of displacement of the cervix. Also, folic acid is recommended for pregnant women or women planning to become pregnant, as it helps in the prevention of birth defects.

5. Oysters - Testicles
Research shows that oysters are very beneficial for male sexual organs. Research conducted in Holland found that a diet rich in oysters contains a lot of zinc and folic acid, which vastly improves the quality of the sperm.

6. Grapefruit- Breast
The similarity between citric fruits and the female breast might be a coincidence, but it is backed by clear health advantages. The peel of the grapefruit contains a petrochemical called Limonoid, and research done on lab animals and human cells has proven that it helps to delay the reproduction of cancer cells, especially breast cancer.

7. Tomato - Heart
If you slice a tomato in half, you'll notice a variety of cells that remind us of the structure of the heart. Research has found that the Lycopene in tomatoes serves as an antioxidant and protects the cellular structures and DNA from free radicals that damage healthy cells, which may contribute to cancer growth.

Also, Lycopene reduces cholesterol levels, which may cause heart damage, and also heart disease. Furthermore, adding a little unsaturated fat to tomatoes (such as olive oil or avocado oil), will allow your body to better absorb the Lycopene.

8. Red Wine - Blood
Red wine is rich in antioxidants and polyphenols, including a material called Resveratrol which contains a wealth of health benefits. The resveratrol protects from damaging factors in the blood, including bad cholesterol (LDL). It also lowers the risk of blood clots and prevents the contraction of the blood vessels, which allows for a better blood flow.

9. Ginger - Stomach
Anyone who's suffered a stomach ache and drank tea with ginger has already felt the influence of this spice, so it only makes sense that it resembles the digestive system. Ginger is known to fight stomach cramps, reduce vomiting and nausea, help with gassy digestions and strengthen the mucus layer in the stomach.

10. Sweet potato - Pancreas
Another food that resembles the organ it helps. The sweet potato is rich in beta carotene, a powerful antioxidant that defends all the tissues in the body, including the pancreas, from damages related to old age or cancer.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     
https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement 

 

15 Ways in Which 3D Printers Can and Are Used in Medicine

3D printing is bringing us closer to the future than we could ever imagine. Perhaps, not the flying cars and hoverboards kind, but the life-saving kind. 3D printing, also known as additive manufacturing, is a marvelous method of printing solid three-dimensional objects, layer by layer, using a digital blueprint. This technology has been in the process of development since the 1980s, and while it has been used in the past to create sculptures, entire houses, and even food, its potential uses in medicine are exponential. Here’s a quick peek into the present uses of 3D printing in medicine and what the future holds!

1. Medical Models
American and Chinese researchers have been using to-scale and accurate 3D printed models of malignant and cancerous tumors to better understand how these tumors develop and spread, and to determine how to create anti-cancer drugs to combat the effects of these tumors.

These models can also be used to plan and prepare for risky surgeries, as was the case in India, where a 3D printed model helped doctors at Jawaharlal Institute of Medical Research in Visakhapatnam plan a surgery on a 4-year-old girl with an overgrown skull.

2. Medical Equipment
In certain less fortunate countries, obtaining good quality medical equipment can be difficult. A 3D printer can make it more viable for poverty-stricken countries to print their own medical equipment. Such was the case with iLabs/Haiti, a result of a partnership between Haiti Communitere, The Blue Marble Movement and KIDmob, which assisted in the purchase of the first two 3D printers in the country. They have since been able to print their own umbilical cord clamps, as well as finger splints and casts.

3. Tailor-Made Sensors
Using scans of animal hearts, scientists and researchers in St. Louis, Missouri’s Washington University, printed 3D models of the heart, around which stretchable silicon electronics were wrapped. These minute electronic sensors, embedded in the silicon could then be peeled off and attached to actual live human hearts, which can detect oxygenation levels, temperature, and heart strain.

The next step in this process would be to create multiple sensors that also have the capability of measuring acidic conditions and detecting blocked arteries. 

4. Facial Reconstruction and Custom Implants
In 2014, a motorcyclist in Wales received numerous injuries in an accident that resulted in the fracture of his skull, nose, jaw and cheekbones. Thanks to developments in the use of 3D printing in medicine, the surgical team at Morriston Hospital created custom surgical guides and implants to perform the surgery and fix the implants to hold the fractured bones in place.

With the use of this cutting edge technology, which was unlike any that had been used by this medical team in the past, not only were the patient's injuries able to be repaired, but his face was able to be reconstructed to hide all such injuries. 

5. Patient Matched Devices
Much like the sensors and medical instruments that can be constructed by 3D printers, which can be made over and over again following an identical blueprint, some devices may be printed in a manner that is specific to the individual patient, that is, patient-matched.

These devices don’t fall under the specified FDA regulations for 3D printed medical devices, nor are they subject to FDA review. To learn more about the creation of such custom-designed devices, you can refer to the FDA-issued Custom Device Exemptions guidance. 

 6. Low-Cost High-Quality Prosthetics
Because of the rigorous and time-consuming nature of creating traditional prosthetics, they can cost a significant sum. This essentially restricts the persons who can purchase them to only those having significant economic means. 3D printing may be the solution to this problem. Another issue with traditional prosthetics is that the delicateness of the prosthetic parts themselves does not lend itself to any modifications.

Researchers at the University of Toronto who created cheap and customizable prosthetics in a short period of time in collaboration with Autodesk Research and CBM Canada. Organizations like Not Impossible Labs, Robohand and E-Nable have been known to hand over 3D printers to countries with high populations of amputees from war, such as Sudan, and train them in the printing of inexpensive patient-specific prosthetic limbs and fitting of the same. 

7. Building Tissues Using Blood Vessels
Before printing tissues and organs, it is vital to have a working vascular system, i.e., a system of blood vessels within an organ allowing it to pump blood and perform its bodily functions. Researchers at various significant institutes, such as the University of Pennsylvania and Harvard University have been working on different methods of bioprinting functioning blood vessels using soluble materials, such as ink and sugar.

These materials are used to create the structure of blood vessels and are then interwoven with skin cells and other living material to create a functioning blood supply, so these vascular systems can, in turn, support 3D printed organ and tissue functions. 

8. Bone
Professor Susmita Bose of Washington State University’s School of Mechanical and Materials Engineering, as well as fellow researchers, have discovered a way to utilize a 3D printer to make a thick bone-like structure, almost identical in appearance and material to bone.

This structure is of use in dental work, orthopedic procedures and can also act as scaffolding in fractured parts of the body on which new bones may grow. This particular material also dissolves as the new bone grows in its place, and leaves no ill-effects on the body after. In time, it is believed that this technology will be developed such that custom replacement bone tissue may be created in this manner.

9. Ear Cartilage and Hearing Aids
Researchers at Cornell University have discovered a new and unique use for 3D photos and models. Associate professor of biomedical engineering, Lawrence Bonassar has been using these 3D prints of human ears to create perfect ear molds, which are then filled with a gel suspended in collagen.
This gel contains bovine cartilage cells and the collagen holds the shape of the ear in place as the bovine cells grow to fill it. Princeton University has taken this methodology a step further and directly created their own 3D printed collagen ear, which comes equipped with built-in electronic sensors that can increase hearing. This is believed to also have many implications for the creation of 3D printed hearing aids.  

10. Drugs
A chemist employed at the University of Glasgow, Lee Cronin, is seen here giving a revolutionary TED Talk on a previously unknown method of using 3D printers. Noting that most drugs are created by chemists who break down certain molecules and combine them with others to create the necessary drug, using its molecular structure and a specifically designed 3D printer, we could potentially print or get printed medical drugs.

It would require a system that utilized both hardware and software to comprehend the biological and chemical necessities of each patient so that each drug could be designed accordingly, and the blueprint of each drug could then be sold to be printed by the patient themselves. Mr. Cronin’s vision is not too far from reality, as Louisiana Technical University has already begun 3D printing devices that are used for delivering medicine for bone cancer patients.   

11. Heart Valve
A 3D printer was first used by a professor at Cornell University named Jonathan Butcher to print a functioning heart valve, which has since been in the stages of testing on animals. Doctors at Tel Aviv University have gone one step further and printed a heart made from human tissue.

The heart itself is extremely minute, but unlike previous 3D printed hearts, which were non-functioning shells, it maintains a system of valves and blood vessels, making it a potentially functioning heart. At this point, it is still in the phase of animal testing, but the development of this method of 3D printing hearts shows many possibilities for progress in the future. 

12. Synthetic Skin
3D printed synthetic skin was first created and brought to light by one professor James Yoo at the Wake Forest School of Medicine in the United States. After scanning the wound, the 3-D printer developed by Dr.Yoo and his team was able to directly print new synthetic skin onto the wounded areas of burn victims. This technology has also been studied in detail for its military application in treating wounded soldiers. Researchers at Carlos III University of Madrid in Spain took this process to the next step and have discovered a way of bioprinting proper human skin, using the biological components of each individual.  

13. Intervertebral Discs
The intervertebral disc is a part of our physiology located in our backs that is often the cause of frequent backaches while sitting or doing ordinary movements, and this pain is usually caused by the degeneration of this intervertebral disc. Dr. Lawrence Bonassar, of Cornell University, and the same brain behind the creation of ear cartilage using 3D printers, has also determined that punctured or broken intervertebral discs can be brought back to their original strength using 3D printers that could accurately print and inject a bio-ink made from stem cells into the patient’s broken disc, along with a healthy dose of collagen to hold the cells in place until their formation is complete.

In Australia, the Royal Melbourne Institute of Technology also created a titanium spinal implant to save a patient with a misshapen vertebra using a 3D printer, which resulted in the straightening of the patient’s spine.  

14. Organs
Much like the heart printed by researchers at Tel Aviv University, Organovo, one of the major organizations doing research into the use of 3D printers for creating human tissue, has been working on developing long-lasting 3D printed liver cells. These liver cells mimic human liver cells exactly and are being used for testing drugs.

Many synthetic organs greatly resembling the real thing have also been printed, which react much like real organs do, but cannot yet be integrated with human anatomy. They are still used in surgical training. While a major hurdle in bioprinting entire functioning organs is the presence of a fully-functioning vascular system, major institutions like Stanford University, University of Sydney, Harvard University, and the Massachusetts Institute of Technology, have noted making significant discoveries in the creation of such capillary systems.

Along with the improvements in 3D Printing technology spearheaded by Organovo and similar organizations like Printer-Inks, which is based in the UK, there are chances that within the decade, 3D printed organs will be a real possibility, making organ transplants a much more viable treatment. 

15. Cranium Replacement         
All across the world, from the Netherlands to Slovakia and China, 3D printers are being used to save the lives of people who have suffered from skull fractures or various forms of brain damage. At the University Medical Center in Utrecht, a 22-year-old patient had the entire top portion of her cranium replaced with a 3D printed plastic replica.

A titanium replacement was similarly made for a man that suffered from skull fractures in China, as well as one in Slovakia. In the United States, an unidentified man had 75% of his skull, which had been fractured for unknown reasons, replaced with a 3D printed replica produced by Oxford Performance Materials (OPM). It is believed that this same technology can be used in bone replacements and will drastically cut down the cost of major orthopedic surgeries. 

this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     
https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement