Sunday, June 08, 2025

Brain Tumour in Kids: Expert shares what every parent needs to know; symptoms, diagnosis and more

 Every human being can have a tumour at any stage of life, and similarly, children are not spared. Brain tumours can occur in children of all ages. It is said that tumours in the extreme of ages are more often malignant or cancerous.

Dr Rahul Gupta, Senior  Neuro and Spine Surgeon, explains that in children, tumours can be located in any part of the brain. These tumours lie within the brain tissue more often than in adults. Hence, the chance of having cancer is higher. Some tumours, like brain-stem glioma, can be benign but behave aggressively like a cancer. Some of these may be associated with syndromes that are due to genetic mutation, and multiple problems are detected in that child. Life is very uncertain for these patients.

What are the symptoms suggestive of a brain tumour?

These tumours most commonly have headache with vomiting, increasing head size, or seizure as the first symptom. In infants, due to blockage of the flow of fluid within the ventricles of Brain, there is increased water collection known as hydrocephalus, which leads to a disproportionate increase in head size.

Young children have headaches with vomiting, irritability, reduced appetite, and loss of weight. Focal or generalised seizures are seen in most tumours and need preventive medicines. Some patients present with eye symptoms/signs like a decrease in vision, double vision, a downward fixed gaze of the eyes known as the sun-setting sign, etc.

Limb weakness or facial asymmetry can also be a feature of a brain tumour in a child. Some patients present with frequent tonic posturing due to raised pressure inside the skull. If not treated in time, these symptoms can lead to coma or even death.

What are the methods of diagnosing brain tumours in children?

Ultrasound can detect tumours or hydrocephalus in infants or even before birth. The most important and harmless investigation to detect a brain tumour is MRI. But in children, sedation or anaesthesia is required to keep the child still for 15 to 20 minutes during the scanning. A CT scan is advised in an emergency to look for hydrocephalus or signs of raised intracranial pressure. Patient is also evaluated for functions of other parts of the body by blood tests, chest X-rays, or ultrasounds of the abdomen.

What are the treatment options for a brain tumour detected in a kid?

Surgery is the main treatment needed in the majority of cases. It helps to establish the tissue diagnosis, reduce the pressure effect of the tumour, and also debulk the mass, making it more suitable for other modalities like radiotherapy. A few children may need an additional VP shunt to divert extra fluid from the brain to the abdominal cavity. It's a relatively simple procedure with good results. Some patients with cancer need radiotherapy and chemotherapy at follow-up.A few of them may be subjected to direct radiotherapy without surgery if the risks of surgery are too high.

Is the surgery difficult?

Anaesthesia during Surgery and postoperative care in ICU is very difficult and complex. Trained paediatric neuroanesthetists are required to handle children. Surgical procedures are also quite demanding and need high-end gadgets and delicate instruments.

Can these kids be cured of Brain tumor?

Quality and longevity of life are quite compromised in cancer patients. However, patients with benign tumours live a long, healthy life if the tumour has been removed safely and completely.

What can be done by parents to prevent or deal with such a situation?

Brain tumours cannot be prevented, as there is no clear reason behind their occurrence.

Parents have a crucial role to play in dealing with these patients. They should recognise early symptoms or signs and report to their family physician asap. MRI or CT scans of the brain should be done at the slightest suspicion. If a brain tumour is detected, then they should visit a well-equipped hospital capable of dealing with such cases. Such hospitals have in-house MRI, an active pediatric Department and Pediatric ICU. Senior neurosurgeons and neuroanesthetists who have experience dealing with children with brain tumours will do a good job. Parents have to be optimistic and emotionally strong. They should follow the advice of the Neurosurgeon and oncologist and refrain from delaying the treatment. Some Parents try alternative therapy, but we have seen them coming back with treatment failure.

The news of having a brain tumour in their child is devastating and disheartening. But parents should keep their morale high and support the child physically, emotionally, and financially. They should be ready for frequent visits to the hospital and timely investigations.


This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   


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Wednesday, March 09, 2022

Lymphatic disorder may cause stillbirth, chronic disease in affected children

In a breakthrough discovery, South Australian researchers have identified a genetic mutation responsible for a lymphatic disorder that may be responsible for causing stillbirth or severe, chronic disease in affected children.

The findings were published in the journal 'Science Translational Medicine'.

An anomaly in the development of lymphatic vessels in unborn children, leading to fluid accumulating in the heart, lungs, and other organs, was uncovered by the scientists from the Centre for Cancer Biology (CCB) based at the University of South Australia (UniSA) and SA Pathology.

CCB Director Professor Natasha Harvey said a genetic study of six families affected by stillbirth or lymphoedema revealed the link between a mutated protein-coding gene called MDFIC and fluid accumulation in vital organs and tissues.

This demonstrated that MFDIC is important for controlling the growth and development of the lymphatic vessels in the foetus for the first time.

"The lymphatic system is a network of vessels (pipes) and nodes (filters and control centres) important for maintaining fluid balance in our tissues and transporting infection-fighting white blood cells throughout our bodies," Prof Harvey said.

"We determined that MDFIC controls cell migration, an important early event during the formation of the lymphatic vessel valves. The genetic variants we have found in our study reveal a crucial, previously unrecognized role for MDFIC in the lymphatic vasculature."

"If the lymphatic valves don't form properly, lymph fluid accumulates in critical organs such as the heart and lungs, causing major respiratory problems that may eventuate in stillbirth or chronic disease."

An SA Pathology research team headed by Professor Hamish Scott initially found the genetic link in an Australian family. Their international colleagues in Belgium, Germany, and the US reported variants in the same gene, MDFIC, in several patients with the same lymphatic disorder.

Prof Harvey said, the disorder, known as the central conducting lymphatic anomaly (CCLA), is one of a group of severe lymphatic disorders and may result in stillbirth, or severe chronic disease in affected children.

Few effective treatments are available but with continued identification of the genetic causes of CCLAs, Prof Harvey says the next step is to develop new therapeutic drugs to combat the disease.

"There are existing drugs that may be used to treat these disorders, but we need to make sure that the signalling pathway that's treated by those drugs is the same pathway that is affected in our patients.

"This project is about the power of collaboration at a local level, national level, and international level, so that's been really important. Science is done in teams and we have great research teams here in Adelaide at the Centre for Cancer Biology. Our Ph.D. students and postdoctoral fellows have been integral to this work. They have really driven it and we're delighted to be working with such a group of talented people."

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   

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Saturday, August 17, 2019

Low awareness on kidney cancer in kids

Wilms tumor or Nephroblastoma, is a rare type of kidney cancer which typically affects children and is rare among adults. It is more common in children aged between 4 months to 4 years but it can also occur in children aged between 3 to 4 months up to 8 to 9 years.

Nephroblastoma, an abdominal and kidney tumour is the most dangerous after the brain. But, there is a lack of awareness about it even among most of the pediatricians.

The main cause of this cancer is due to ‘Genetic Mutation’ which can be from either of the parent side. It is also more common in various genetic syndromes which can affect the child. Sometimes, the abnormal cells in the baby multiply in its early state and become a tumor which is usually detectable at the age of 3 to 4 years. In India, it affects 120 children out of 1 million a year, where as it is seen in almost 50 to 60 % of children which puts them at a higher risk.

A person might experience no symptoms during its early stages. However, a baby cannot verbalize or express it. A mother can find a hard mass around the baby’s stomach and swelling near its abdomen and lower chest regions. Other symptoms also include blood in urine/abnormal urine, poor appetite, constipation, vomiting, fever and unexplained weight loss.

A Pediatric Oncologist said, “It is very important for the parents to examine the baby while giving a bath and notice their regular activity in terms of their appetite, energy levels etc. If the parents feel something is irregular they have to take the baby immediately to a physician and make sure treatment is given at the right time. If there is any tumor or mass found near the abdomen, the baby has to be taken to an oncologist immediately. There should be no delay in starting the treatment because the success rate at which it can be cured is higher when it’s picked up in early stages.”         

The treatment for Wilms tumor depends on when a baby is picked up. The treatment is suggested with the combination of surgery as well as chemotherapy. If it is meta static at the time of picking up the baby then the therapy is started, the tumor is removed and a ‘radiation therapy’ (treatment for cancer, thyroid disease, blood disorders and non-cancerous growth) will be suggested.

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