Pregnant? A diet with ghee & butter can protect your baby from Alzheimer’s disease

To all the moms to be, here’s some advice: don’t avoid ghee!

The advice given by our elders, especially by our grandparents is not worthless. Rather, it is backed by logic. We all must have seen our grannies suggesting high-fat diets to the pregnant women in the house. Well, scientists have found out the reason behind this.

A study has revealed that a high-fat diet during gestation guards the fetus against changes in the brain that may lead to Alzheimer’s disease later. See how smart our grannies are? Kudos to them!

But before we proceed further, let’s find out what Alzheimer’s exactly is?
Simply put, it’s a form of dementia which ultimately leads to memory loss and other cognitive abilities. The most common symptoms are memory loss, inability to learn new things, problem in writing, reading, calculating, restlessness, anger, depression, hallucination, and inability to combine muscle movements. And there is no cure.

Although the risk of this disease comes in old age, there is no harm in preventive care.

Yes, at an old age this situation can be terrifying. But let’s see what experts have found out.
Recently a study was published and we quote, “In humans, it has been known that individuals whose mothers develop Alzheimer’s disease after the age of 65 are at increased risk of also developing the disease around the same age,” said senior investigator.

Genetic factors transmitted by mothers to their offspring seem like an obvious explanation behind this phenomenon, but so far no genes have been identified that could explain the maternal transmission of Alzheimer’s disease.

To better understand the unique relationship between maternal Alzheimer’s disease and risk in her offspring, researchers looked at maternal fat intake specifically during the gestation period in mice engineered to develop Alzheimer’s disease.

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Pregnant mice were fed a high-fat diet from the beginning until the end of gestation. The moment offspring were born, mothers were switched to a regular diet, which was maintained during the lactation period. Offspring of these mothers were always kept at the same regular or standard diet throughout their life.

At 11 months of age, offspring underwent behavioural tests to assess learning ability and memory. “Surprisingly, we’ve found that animals from mothers fed a high-fat diet during gestation had better learning and memory skills than their counterparts born to mothers fed a regular diet during gestation,” the Dr. said.

The observed improvements in memory and learning were associated with the maintenance of good synaptic integrity. In fact, offspring from mothers exposed to a high-fat diet had significant improvement of synapse function when compared with offspring from mothers on a regular diet. 

Synapses, the places where neurons come together to relay information, play a vital role in learning and memory formation.

If expecting, then don’t hesitate the high-fat intake as it’s not just good for you but for your kid as well.

Here is why sitting all day isn't good for health

Sitting Disease. It sounds like some mysterious condition you’d bring back from an exotic vacation, but it’s actually a modern homegrown ailment caused by going from the breakfast table to the driver’s seat, from your desk to the car to the sofa for the evening, with little movement otherwise. 

The staggering amount of time many of us spend being sedentary-up to 15 hours a day if we work in an office, according to one study-can lead to problems inside and out. You’re probably familiar with the aches and pains caused by hunching over a computer, but spending too much time in a chair or slumped on the sofa also has been linked to several life-threatening conditions, including blood clots, nonalcoholic fatty liver disease, heart disease, and cancer. Not even your brain is spared: In April 2018, researchers published a study that found an association between sedentary behavior and thinning of the regions of the brain that are critical to memory formation. 

The issue with sitting goes beyond concern about obesity, although being overweight can increase the risk of many of the same conditions linked to sitting too much. And yes, clocking so many hours in your seat can make it harder to maintain a healthy weight: “When you’re sitting, you’re burning only half the calories you would standing or walking lightly,” says a doctor.

But even if you’re trim, a sedentary lifestyle may still wreak havoc on your health. That’s because “lack of movement affects how we burn fat and metabolize sugar and the body’s response to insulin,” says Dr. Your cholesterol may also go up, along with markers of inflammation and troponins (a protein produced by cardiac muscle cells when they’re hurt or dying). Such physiological changes can nearly double your odds of diabetes and increase your risk of cardiovascular disease by 14 percent. 

In a small study last year, researchers took a group of healthy young adults who regularly clocked at least 10,000 steps a day and had them cut back to 1,500 steps. Participants still went to work and took care of their families, says a researcher. It was no surprise that within two weeks, subjects increased total body fat, particularly around their middles, and lost muscle mass. But strikingly, the group also experienced a decrease in insulin sensitivity and an increase in both fat accumulated in the liver and triglycerides. Staying sedentary had consequences that were both swift and potentially serious in the long term. These changes were all reversible when participants resumed their normal activity regularly.

The health effects of sitting too much

Sitting as much as many of us do increases our chance for some 35 serious conditions, likely because getting up and moving around is key for regulating proteins, genes, and other systems that lower our susceptibility to disease. Below, the effects of “sittingitis”: 

1. Depression and anxiety

The more you sit at work, the greater your risk, even if you exercise, a study in Mental Health and Physical Activity found. On the flip side, other research shows that the more people move throughout the day, the happier they are.

2. Back and neck pain

Just four hours of sitting can compress a key disc in your lower back, says an associate professor of orthopedics and rehabilitation. Poor posture can also lead to disc problems in your neck.

3. Cancer

Risk of colon and endometrial cancer goes up even after accounting for exercise, possibly due to inflammation, weight gain, and other changes. One review reports that for every additional two hours per day spent sitting, risk jumps 8 percent and 10 percent for colon cancer and endometrial cancer respectively.

4. Obesity, diabetes, and heart trouble

Yes, you burn fewer calories sitting, but also the hormone insulin’s ability to move glucose out of blood and into cells may decline when you sit for long periods, Dr. Alter says. Cholesterol and markers of inflammation may go up; how you metabolize fat changes; and vascular function may be reduced.

5. Weak bones

Weight-bearing exercise, including standing and walking, stresses your skeleton in a good way, signaling specialized cells to replace old bone tissue with new. When you sit too much, the body replaces less of what it loses, leading to fragile bones and a greater risk of osteoporosis, especially as you get older.

6. Blood clots

Slow blood flow in the legs from a sedentary lifestyle, possibly along with lower levels of clot-preventing proteins, increases your risk. Women who sat for more than 40 hours per week had more than double the risk of a clot moving to their lungs compared with those who sat less than 10 hours.

Can getting more exercise help?

Chairs are hardly a modern invention, but roughly 200 years ago, people sat for just five hours a day. The rest of their waking hours were filled with physical exertion: manually laundering clothes, kneading bread, walking places, working in the garden, you get the idea. If your great-great-great-great-great-great-grandma didn’t swear by her Spin class, it’s as much because she was doing a low-key workout from sunup to sundown as due to the fact that those classes didn’t exist. Today, including eight hours of slumber at night, we may move as little as 60 minutes each day.

Were our ancestors cocooned from the perils of a sedentary lifestyle because they were moving more, or because they weren’t sitting as much? 

There’s no question that hitting those targets can help your health and improve your longevity. But it may take more than double that amount of conscious exercise to offset the time you spend sitting: A study analyzed data from more than 1 million adults found that it took 60 to 75 minutes of moderate cardio per day to wipe out sitting’s higher risk of premature death. And even the most active participants saw an uptick in mortality risk when they sat in front of the TV for five or more hours a day.

That means exercise, while worthwhile, doesn’t completely make up for sitting. When researchers strapped activity monitors on nearly 8,000 adults 45 and older, they found that sitting for 12 or more hours a day increased the odds of early death regardless of exercise habits. And the risk was especially high if chair time was in uninterrupted stretches of 60 to 90 minutes, says the study’s lead author and an assistant professor of behavioral medicine. “It’s simply not enough to be active or move at one specific time of the day,” says the author. “We need to be mindful of moving frequently throughout the day in addition to exercising.”

How to mix in more movement

Before you quit your job or swap your washing machine for a washboard and a scrub brush, know this: Moving more doesn’t have to be an all-or-nothing endeavor. You can have your modern life and conveniences (thank you, already-churned butter!) without fear that you’re harming your body. The main trick is to scale back both your sitting and how many consecutive minutes you spend in one seat. 

A study showed that people who targeted their sitting time with a specific strategy-say, switching to a standing desk or walking to the water cooler more often-were more effective in reducing their sedentariness than those who focused on adding more exercise sessions into their days.

So work on replacing at least two hours of tush time with movement breaks-a shift associated with all sorts of benefits, including 14 percent lower triglycerides, higher “good” HDL cholesterol, a trimmer waistline, and better glucose control, according to a study. “Little breaks don’t seem like much, but they add up,” says the Dr.  In fact, two hours spread over the roughly 16 hours you’re awake is about eight minutes an hour, and you can do those in spurts. One study has shown that adding two minutes more walking to each hour can decrease a person’s risk of dying by 33 percent.

You might also find that there are times you can eliminate sitting entirely. Must you call your sister from the sofa, or could you chat while strolling? What if you prepped dinner while standing at the counter or passed up a seat on the train? The fact that women who sat the most had more than twice the risk of a clot moving to their lungs compared with those who sat the least makes it easier to think of perching as a last resort.

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How Our Diet Can Impact Memory

Although you might be familiar with the statement, "you are what you eat", the food you consume could also impact your memory, suggests a new study.
A team of researchers discovered that cholecystokinin (CCK), a satiety hormone which is highly expressed in memory formation, could, at higher levels, decrease a person's likelihood of developing Alzheimer's disease by 65 per cent, said a study published recently.

CCK is found in both the small intestines and the brain. In the small intestines, CCK allows for the absorption of fats and proteins. In the brain, CCK is located in the hippocampus, which is the memory-forming region of the brain, said a Prof.
 
"The regulation of when and how much we eat can have some association with how good our memory is. what we eat and what our body does with it affects our brain.

"It will hopefully help to shed further light on how satiety hormones in the blood and brain affect brain function," the Prof. said.

The researchers hope this study will encourage others to look into the nutritional aspect of diets, versus just looking at caloric intake.

The lead author and graduate student at the varsity, is currently looking at how diet impacts an individual's CCK levels through researching fasting glucose and ketone bodies.

"By looking at the nutritional aspect, we can tell if a certain diet could prevent Alzheimer's disease or prevent progression of the disease," he said.

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Just a few drinks may change how memories are formed

Just a few drinks in an evening may change how memories are formed at the fundamental, molecular level, a study suggests.

One of the many challenges with battling alcohol addiction and other substance abuse disorders is the risk of relapse, even after progress towards recovery, said researchers.

Even pesky fruit flies have a hankering for alcohol, and because the molecular signals involved in forming flies' reward and avoidance memories are much the same as those in humans, they are a good model for study, they said.

The study, published in the journal, in flies found that alcohol hijacks this memory formation pathway and changes the proteins expressed in the neurons, forming cravings.

Researchers uncovered the molecular signalling pathways and changes in gene expression involved in making and maintaining reward memories.
 
"One of the things I want to understand is why drugs of abuse can produce really rewarding memories when they're actually neurotoxins," said, an assistant professor. The team used genetic tools to selectively turn off key genes while training the flies where to find alcohol. This enabled them to see what proteins were required for this reward behaviour.

One of the proteins responsible for the flies' preference for alcohol is Notch, the researchers found.
Notch is the first "domino" in a signalling pathway involved in embryo development, brain development and adult brain function in humans and all other animals.

Molecular signalling pathways are not unlike a cascade of dominos -- when the first domino falls (in this case, the biological molecule activates), it triggers more that trigger more and so on.

One of the downstream dominos in the signalling pathway affected by alcohol is a gene called dopamine-2-like receptor, which makes a protein on neurons that recognises dopamine, the "feel-good" neurotransmitter.

"The dopamine-2-like receptor is known to be involved in encoding whether a memory is pleasing or aversive," a researcher  said. Alcohol hijacks this conserved memory pathway to form cravings.

In the case of the alcohol reward pathway studied, the signalling cascade didn't turn the dopamine receptor gene on or off, or increase or decrease the amount of protein made, she said.

Instead, it had a subtler effect -- it changed the version of the protein made by a single amino acid "letter" in an important area.

"We don't know what the biological consequences of that small change are, but one of the important findings from this study is that scientists need to look not only at which genes are being turned on and off, but which forms of each gene are getting turned on and off," she said.

"We think these results are highly likely to translate to other forms of addiction, but nobody has investigated that," she said.

The Prof. is working with an assistant professor , to look at DNA samples from patients with alcohol abuse disorders to see if they have genetic polymorphisms in any of the craving-related genes discovered in flies.

"If this works the same way in humans, one glass of wine is enough to activate the pathway, but it returns to normal within an hour," she said.

"After three glasses, with an hour break in between, the pathway doesn't return to normal after 24 hours. We think this persistence is likely what is changing the gene expression in memory circuits," she said .

"Just something to keep in mind the next time you split a bottle of wine with a friend or spouse," she said.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                                                                                                                                       PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/   

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