Study suggests feasibility of treating encephalopathy with gene therapy

A new study has highlighted that it is feasible to use gene therapy for treating chronic traumatic encephalopathy ( CTE) which is a progressive neurodegenerative disorder.

Researchers demonstrated the effectiveness of the direct delivery of gene therapy by delivering it into the brain of a mouse.

CTE is much more prevalent than was initially realised, and there is currently no therapy available. This new work is potentially ground-breaking as a means to remove the offending Tau phoshoprotein, said the lead researcher.

The disease which is caused by recurrent trauma in the central nervous system, such as those suffered by soldiers, atheletes in contact sports and in accidents, is currently incurable.

Inflammation results in the accumulation of hyperphosphorylated forms of Tau protein (pTau). 

Researchers developed an adeno-associated virus (AAV) vector to deliver an anti-p-Tau antibody to the CNS. They showed that direct delivery of the AAVrh,10anti-p_tau directly into the hippocampus of brain-injured mice was associated with a significant reduction in p-Tau levels across the CNS.

They propose that doses could be scaled up and this strategy could be effective in humans as well.

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Blood pressure issues? Try hot yoga

Researchers have found  that taking hot yoga classes lowered the blood pressure of adults with elevated for stage 1 hypertension.

While there is evidence of regular, room-temperature yoga's positive effect on blood pressure, little is known about hot yoga's potential impact on blood pressure, said researchers who presented the study recently.

The results of the study start the conversation that hot yoga could be feasible and effective in tems of reducing blood pressure without medication, said the study's author.

Hot yoga is a modern practice, typically offered in a hot, humid atmosphere, with room temperatures around 105 def. F. /around 41 deg. C.

For the study, the researchers recruited 10 men and women, between 20-65 years. Participants had either elevated blood pressure ( systolic BP between 120mmHg- 129 mmHg and diastolic pressure less than 80mmHg) or stage 1 hypertension ( 130mmHg-139mmHg systolic and 80 mmHg-89mmHg diastolic pressure).

The research team randomly assigned 5 participants to take 12 weeks of 3 times-weekly hour long hot yoga classes and they assigned the other 5 to a control group of no yoga classes.

They compared the average BP pf the 2 groups after 12 weeks.

The researchers looked at average 24-hour BP readings, as well as perceived stress and vascular function of participants in both groups.

They found systolic BP dropped from an average 126mmHg at the study's start to 121 mmHg after 12 weeks of hot yoga.

Average diastolic pressure  also decreased from 82mmHg to 79 mmHg in the hot yoga group.
According to the study, average BP did not change among the 5 adults in the control group, those who did not take hot yoga classes.

Perceived stress levels fell among those in the hot yoga group but not in the other group.

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Researchers have found that taking hot yoga classes lowered the blood pressure of adults with elevated or stage 1 hypertension. While there is evidence of regular, room-temperature yoga's positive effect on blood pressure, little is known about hot yoga's potential impact on blood pressure, said researchers who presented the study at Hypertension 2019 Scientific Sessions in the US.

https://thehansindia.com/hans/young-hans/blood-pressure-issues-try-hot-yoga-561703

Digital medicine may help treat kids with autism, ADHD

The study confirmed the feasibility and safety of the tool called Project: EVO, which delivers sensory and motor stimuli through an action video game experience. As many as 50 per cent of children with ASD have some ADHD symptoms, with roughly 30 per cent receiving a secondary diagnosis of ADHD. 

However, since ADHD medications are less effective in children with both disorders than in those with only ADHD, researchers are exploring alternative treatments. Children with ASD and ADHD symptoms are also at high risk for impaired "cognitive function," including the brain's ability to maintain attention and focus on goals while ignoring distractions. As children reach school age and beyond, these cognitive impairments make it more difficult for them to set and achieve goals, as well as successfully navigate the demands of day-to-day life in the community. 


"Our study showed that children engaged with the Project: EVO treatment for the recommended amount of time, and that parents and children reported high rates of satisfaction with the treatment," said  a child psychologist. "Based on the promising study results, we look forward to continuing to evaluate the potential for Project: EVO as a new treatment option for children with ASD and ADHD," said the Prof. 

The study included 19 children aged 9-13 diagnosed with ASD and co-occurring ADHD symptoms. Participants in the study were given either the Project: EVO treatment, which is delivered via an action video game experience, or an educational activity involving pattern recognition. Key secondary outcome measures were caregiver reports of ADHD symptoms and the ability of the child to plan and complete tasks, as well as a cognitive test battery assessing working memory. 

The study found that children adhered to the treatment protocol by engaging with the treatment for 95 per cent or more of the recommended treatment sessions. Both parents and children reported that the treatment had value for improving a child's ability to pay attention and served as a worthwhile approach for treatment. The study also found that after using Project: EVO, children showed a trend toward improved attention, and they showed general ADHD symptom improvement based on parent reports. Though the sample size of the study was small, the study showed that using Project: EVO was feasible and acceptable with potentially therapeutic effects. The research team is planning a larger follow-up study for continued evaluation of Project: EVO's potential efficacy. 

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