COVID-19 may cause fatal blood clots! Doctors raise concern over harm caused from brain to toes

Coronavirus may cause fatal blood clots, thereby harming organs from brain to toes, a Bloomberg report indicates. Doctors have raised concerns about recent blood clotting disorders, which are now one of the ‘most important things’ to have recently emerged in the world’s fight against COVID-19. 

At times, these clots are not always life-threatening and can also exist as one of the clinical conditions of the Covid-19. Clots affect infected people in range from the formation of clots in one’s toes to blockages of blood vessels and subsequent strokes and infarctions. Notably, increasing the risk of blood clotting is not uncommon for infections. The Spanish flu pandemic of 1918, caused by a novel strain of influenza that killed about 50 million people worldwide, was also related to downstream clot destruction that could drastically end lives.

Viruses like HIV, dengue, and Ebola are all known to cause clumping-prone blood cells. In patients with coronavirus the pro-clotting effect can be even more pronounced. The clots which block blood flow in the lungs are more dangerous, causing difficulty breathing.

Researchers in China reported coagulation disorders in Covid-19 patients in February but their frequency has since become clearer. Doctors are looking at blood clots or coagulation as one of the possible reasons for lung damage. However, they still attribute majority of damage to viral pneumonia.

Dr. Anthony Fauci who heads the US’ National Institutes of Allergy and Infectious Diseases and also at a key position in president Donald Trump’s Covid-19 response team has said that autopsies of patients who have died recently are revealing some unexpected information. In an interview with CNN last week, he said that presence of thrombi or clumps of blood as a possible reason behind the rapid and dramatic deterioration of the patients.

Separate studies from France and the Netherlands found that as many as 30 per cent of seriously ill Covid-19 patients had a so-called pulmonary embolism — a potentially deadly blockage in one of the lung arteries. Sometimes these arise as pieces of blood clots in veins deep in the legs and migrating to the lungs.

Doctors are having a tough time treating the patients with the highly infectious Coronavirus that has infected more than 2 million people across the world.

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clearest statement regarding Coronavirus from a doctor

Marc Serota (one of our former allergy fellows at Children's Mercy) posted this on Facebook. I think it is the clearest statement regarding Coronavirus I have seen per one of our Current Asthma/allergy Doctors:

From an MD immunologist:

I don't post a lot on Facebook but I would like to give my perspective and context on the coronavirus outbreak. I hope I can be a more reputable source of perspective as a physician who specializes and is board certified in immunology (as well as pediatrics, allergy and dermatology).

1. Coronaviruses are a family of viruses. "coronavirus" is not unique to this particular strain. Everyone reading this has likely had another different coronavirus infection. This particular strain has been named COVID-19.

2. Every upper respiratory virus has the potential to be lethal. Patients unfortunately die from many upper respiratory viral infections every year - most prominently the influenza virus. 30,000 people died from the influenza virus in 2019. The media didn't report each one. They have reported all 11 coronavirus deaths. Not telling us about the people lost but rather keeping a death "toll".

Let me repeat that: 

-Coronavirus: 11 deaths (US in 2020), 3300 deaths (China in 2020).  

-Influenza: 30,000 deaths (US in 2019). 

*Influenza pandemic of 1918: 675,000! (US), 20-50 MILLION!! (worldwide) <---these annual="" been="" favor="" flu="" font="" have="" i="" in="" of="" people="" receiving="" their="" think="" vaccine.="" would="">

This is not meant to minimize any of these deaths but rather to give context and put some facts to the hysteria.

3. If you're healthy, there is no need to walk around wearing a mask. In addition to looking silly and most of the time wearing/taking them off wrong - which would actually make you more prone to acquiring an infection, they don't prevent you from getting sick. If you're actually sick stay away from people and then, sure, wear a mask so you aren't spreading respiratory droplets every time you cough/sneeze. In medicine we don't wear the masks you're buying and we wear other protective equipment - not just a silly looking mask you found on Amazon. When you see doctor's walking around the world wearing a mask then you should too. Until then, stop.

4. The symptoms are that of the flu. As doctors we don't test or know about most people with mild or moderate flu symptoms. That means most people will probably get it and just think they had the flu. That means you're only going to hear about the cases that get serious - not all the minor ones which will be the vast majority of cases.

5. When it is said that people who are older or have other medical conditions are most likely to die - that is equally true for EVERY upper respiratory virus. There is nothing unique about that to this particular virus. It does mean that the only cases we tend to know about are the severe ones. Once a case is severe it then makes sense to test the patient to find out what virus in particular they have. That means you can easily overestimate how severe or lethal the virus is because the only cases you end up knowing about are the serious ones.

In summary 30,000 people died from the flu last year. Another 30,000 died in car accidents.  

I remember: H1N1 (2009), MERS (2012), Ebola (2014), Coronavirus (2020).  

Take it from me: The poor resident who stood at the door of the ER to triage people in 2009's swine flu (H1N1) hysteria. The over reaction is exponentially worse than the actual problem and in 2020 the over reactions I'm seeing are remarkable. In cold and flu season you'll probably get sick once or twice for about a week each. You might even get this particular coronavirus and most of you won't even know it. I've seen people raiding supermarkets, major meetings and sporting events getting cancelled and fear/racism towards Asian people. These reactions are totally unnecessary and panic based. Just do what you've always done during cold/flu season. Stay away from other people when you're sick, wash your hands and keep them away from your face, and only go to the ER if you feel your symptoms are more severe than a bad cold/flu (shortness of breath, high fever, etc.). And also realize you can't live on earth and not get viral illnesses from time to time. It's a part of nature.

Please don't ask for antibiotics (those treat bacteria - not viruses). That's like asking for a fire extinguisher when you're drowning. It can be a life saving device - but the wrong one for the problem at hand. Some doctor's don't want to fight about it when patients insist on antibiotics so they just prescribe them - but it doesn't mean its actually helping you and in some cases they can be harmful (resistance, infections, allergic reactions just to name a few). If you're one who asks for antibiotics every time you're sick, again, take it from me: ask for a flu shot each year and a doctor's note to stay home from work when you're sick instead. You will be much better off.

The government is very proud that testing will be available to every American. Remember, we don't test for any respiratory virus other than the influenza virus routinely. The reason is thats the only virus that has a treatment (pill) you can take to shorten the duration of severity of the illness. I suspect if we start testing everyone with cold symptoms for coronavirus we're going to find lots of it. It's not going to change the recommendations to stay home and rest. And its not going to predict the small percentage of people who may develop more severe symptoms. Essentially whether someone has coronavirus 19 or some other cold/flu virus isn't going to matter to your doctor. What it will do is slam urgent cares, ER's and hospitals with every patient who has a cold so they can be tested. It is much more sensible to reserve testing for patients requiring hospitalization or more advanced treatments. Even that wouldn't change their management but would be more to confirm the diagnosis and to not waste time looking for other causes of the patients symptoms.

In conclusion, yes there is a novel virus that our immune systems haven't seen yet so to get immune to it you will have to get infected - at least until a vaccine is developed to bypass the getting sick part and just jumping straight to immune. Most people's immune systems will do that effectively and be fine. A small percentage of unfortunate patients (primarily elderly, immune compromised etc.) will not be able to do that effectively and will need more advanced care. This is true of the cold/flu viruses we deal with every year. Follow normal cold/flu precautions and seek medical care if you feel your symptoms are severe. No need to get hysterical.

These outbreaks can be instructive for overall knowledge of public health. In particular showing your immune system the uniform of a potential invader (virus) so that if it ever sees a soldier wearing that uniform it will immediately attack and neutralize it without you ever getting sick. That is a wonderful thing and probably the single biggest achievement in medicine throughout human history. That is what vaccines are. The benefit to risk ratio of them are off the charts in favor of vaccines. If viruses like coronavirus scare you, then stay up to date on your vaccines and your immune system will be running the latest software.

If you still think you should be scared consider this: Doctors, nurses and other healthcare staff are going to hospitals every day. Crowded buildings with tons of sick people. They aren't walking around the halls of the hospitals wearing masks and they haven't stopped going to work. And they are all rolling their eyes at everyone else right now.

Marc Serota, MD

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

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https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
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Protein to combat Ebola discovered in humans

Researchers have discovered a human protein that helps in fighting the Ebola virus.

In the study, the team used mass spectrometry -- a technique that identifies specific elements in a sample by mass -- to search for interactions between human proteins and Ebola virus proteins.

They found strong evidence for an interaction between the Ebola virus protein VP30 and the human protein RBBP6, it was  reported on Thursday.

      
Further, structural and computational analysis narrowed the interaction down to a small, 23-amino acid-long peptide chain. This small group of amino acids alone is sufficient to disrupt the Ebola virus life cycle.

"If you take that peptide and put it into human cells, you can block Ebola virus infection," said co-lead author , an assistant professor of medicine.

"Conversely, when you remove the RBBP6 protein from human cells, Ebola virus replicates much faster.

"This is a key interaction," said a senior author of the study and a professor of cellular and molecular pharmacology.

"The question is whether we can manipulate it in an effective pharmacological way for it to have therapeutic value."

"What we envision is a small molecule drug that mimics this human protein and could be used in response to an Ebola virus outbreak," said the Prof.

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AAV Gene Therapy Successfully Protects Against Ebola in Mice

Infectious disease researchers have discovered a new method for effectively protecting against and treating Ebola infections. The study, performed in mice, used an adeno-associated virus (AAV) to deliver monoclonal antibody genes against Ebola. Similar viral vector treatments have been used to effectively treat human immunodeficiency virus (HIV) infections.

“Our goal is to make an antibody-based therapy that can protect against all strains of Ebola, and potentially Marburg virus, as well,” says Prof., who, along with PhD student found a new way to fight Ebola. “It would be used to stop the spread of the virus in outbreak situations.”

Traditional monoclonal antibody (mAb) treatments for Ebola are promising but are limited by the resources required for production and the immunity they provide is short-term. Using a viral vector method, anti-Ebola monoclonal antibody genes are delivered to the cell and the cell will produce the antibody and secrete it into the bloodstream to fight an infection. The research team demonstrated that in mice, 100 percent protection was provided against an Ebola infection with a mixture of two different types of antibodies and 83 percent protection was provided with a different antibody cocktail. The gene therapy was shown to provide protection from the disease for five months following administration.

“We are hoping to use this technology in a post-exposure scenario. Let’s say someone has been exposed to Ebola. The idea would be to give them this AAV vector to start producing the antibodies that prevent death, commented the Prof.”

The preliminary findings are promising and the team is moving forward to develop a gene-based therapeutic or vaccine to Ebola or one that can be used to treat other filovirus infections such as Marbug.

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Gold nanoparticles could help combat all deadly viruses

Researchers have developed gold nano-particles that can potentially "trick" viruses into thinking they are invading a human cell and then destroy them -- a finding that would help develop a single drug to combat viruses that cause diseases such as HIV, dengue, papillomavirus, herpes and Ebola, all at the same time.

Viruses infect human bodies by binding to cells. 

Once injected in the body, these nano-particles imitate human cells and "trick" the viruses. 

When the viruses bind to the nano-particles, to infect them, the resulting pressure deforms the virus and opens it, rendering it harmless. Unlike other treatments, the use of pressure is non-toxic.

"Viruses replicate within cells, and it is very difficult to find a chemical substance that attacks viruses without harming the host cells," said a researcher.

"But until now, that's been the only known approach attempted permanently to damage viruses," he added.

However, the gold nano-particles are harmless to humans, and they imitate human cell receptors -- specifically the ones viruses seek for their own attachment to cells. 

The novel nano-particles is unique in that it achieves permanent damage to the viral integrity without damaging living cells, the researchers said.

Moreover, the broad-spectrum antiviral drugs would also help curb the antimicrobial resistance resulting from the over-prescription of antibiotics, revealed the study.

"Doctors often prescribe antibiotics in response to viral infections, since there is no other drug available. But antibiotics are only effective against bacteria, and this blanket use fosters the development of virus mutations and a build-up of resistance in humans," the researcher said.
 
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