Protein to combat Ebola discovered in humans

Researchers have discovered a human protein that helps in fighting the Ebola virus.

In the study, the team used mass spectrometry -- a technique that identifies specific elements in a sample by mass -- to search for interactions between human proteins and Ebola virus proteins.

They found strong evidence for an interaction between the Ebola virus protein VP30 and the human protein RBBP6, it was  reported on Thursday.

      
Further, structural and computational analysis narrowed the interaction down to a small, 23-amino acid-long peptide chain. This small group of amino acids alone is sufficient to disrupt the Ebola virus life cycle.

"If you take that peptide and put it into human cells, you can block Ebola virus infection," said co-lead author , an assistant professor of medicine.

"Conversely, when you remove the RBBP6 protein from human cells, Ebola virus replicates much faster.

"This is a key interaction," said a senior author of the study and a professor of cellular and molecular pharmacology.

"The question is whether we can manipulate it in an effective pharmacological way for it to have therapeutic value."

"What we envision is a small molecule drug that mimics this human protein and could be used in response to an Ebola virus outbreak," said the Prof.

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