Insulin and glucagon combo- Novel approach for blood sugar control in diabetes

Co-administration of insulin and glucagon provides protection against insulin-induced hypoglycemia without worsening hyperglycemia in type 1 diabetes (T1D) patients, according to a recent study published in the ADA journal Diabetes.This essentially means that this combo will control high blood sugar along with protection from sudden and severe fall in blood sugar in type 1 diabetes.

The results were also presented at the American Diabetes Association' (ADA) Virtual 80th Scientific Sessions.

Despite advances in the pharmacological and technical fields, the risk of hypoglycemia remains the major concern for the regulation of optimal blood sugar levels in type 1 diabetes. there is an increasing interest in how the opposing actions of insulin and glucagon (Gn) may be harnessed to optimize glycemic control.

For the purpose, Bruce W. Bode from Atlanta, GA, and colleagues studied 11 T1D patients (age 36±4y, gender M:F 5:6, BMI 25.0±0.7 kg/m2, disease duration 23±3y, A1C 7.0±0.3%, daily insulin dose 43±3u) on two occasions, under meal challenge conditions (liquid mixed meal, 100g carbohydrate) during a phased 6h IV regular insulin infusion with (+Gn) and without (-Gn) IV glucagon. On both occasions, subjects were treated overnight with low dose IV insulin prior to the morning meal to prevent antecedent nocturnal hypoglycemia and to attain near-normal fasting glycemia.

Insulin dosing was designed to control the early rise in plasma glucose (PG) but also to elicit hypoglycemia in the later phase.

 

Key findings of the study include:

During +Gn, glucagon was co-administered with insulin at a fixed molar ratio. At the two visits, fasting PG was similar (-Gn 121±5, +Gn 119±6 mg/dl) and the initial meal-induced PG elevation (0-3h) was indistinguishable whether glucagon was present or not (peak PG -Gn 224±18, +Gn 228±15 mg/dl; ΔPG 0-180AUC -Gn 10501±3014, +Gn 11537±1778 mg.min/dl).

 

During the latter phase (3-6h), 7/11 -Gn subjects experienced an excessive fall in PG to <80mg 50mg="" 5="" by="" dl="" dropping="" font="" glucose="" iv="" nbsp="" protocol="" requiring="" rescue="" to="" with="">

During +Gn, the fall in PG was attenuated in all cases with a significant difference observed in PG nadir (-Gn 51.1±4.0, +Gn100.5±11.0 mg/dl). 

Appropriate elevations in plasma insulin and glucagon were observed in keeping with study design.

"To conclude, it is feasible that insulin and glucagon can be co-administered under specific conditions allowing protection against insulin-induced hypoglycemia without impeding hyperglycemic control. This unique observation offers insight into novel approaches to glucose control in diabetes," wrote the authors.

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TURMERIC, THE WONDER SPICE

Turmeric has been linked to a number of health benefits, including weight loss and cancer prevention. There are so many amazing health benefits of drinking warm turmeric water or turmeric tea every morning on an empty stomach. Turmeric, also known as Haldi in Hindi, has been used for both culinary and medicinal purposes for ages. Adding this magical spice to your daily diet provides you with a range of health benefits. The Curcumin, which is the main active ingredient in turmeric, has many therapeutic properties, including weight loss. It can protect the body from various disorders linked to obesity and contains powerful anti-inflammatory effects and is a very strong antioxidant.

How does turmeric tea work for weight loss?

1. Turmeric tea has anti-inflammatory properties

Inflammation is greatly associated with obesity or excessive fat deposition in the body. As we all know, turmeric is an anti-inflammatory spice that helps reduce inflammation and thus helps in losing weight.

2. Turmeric tea is great for digestion

A good digestive system is the key to lose weight. Turmeric tea helps relieve stomach disorders like bloating, gas and also improves bowel movements, which helps you lose weight.

4. Turmeric tea helps increase bile production

Regular consumption of turmeric tea helps to increase the bile production present in the stomach. It is a digestive juice that helps in emulsifying fat and its metabolism. This process makes this spice very helpful to lose weight.

5. Turmeric tea helps regulate blood sugar levels

Turmeric tea helps regulate sugar levels and prevents insulin resistance. 

6. When to take turmeric tea for weight loss?

It is believed that drinking warm turmeric water or turmeric tea on an empty stomach can effectively help your body burn excess flab….and that’s the secret to this miracle drink!!
7. Does turmeric tea work for weight loss?

One should surely try to incorporate turmeric in every meal. Drinking turmeric tea along with moderate exercises, a healthy and balanced diet is what will help you lose weight in a healthy manner in the long run. 

How to make Turmeric Tea

Ingredients

• 2 tbsp Turmeric powder
• 1/2 tbsp Black Pepper Powder
• 1/2 tbsp Ginger Powder
• 1/2 tbsp Cinnamon Powder
• 1/4 tsp Cardamom Powder

Instructions

• Take all the dry ingredients in a bowl.
• Mix well, transfer and store it in an airtight container, sealed tightly.

To make Turmeric Tea:

• Add 1/2 tsp of the turmeric tea powder mix to a glass and pour boiling hot water over it. Mix well and allow it to seep for about 5 to 7 minutes.
• You can add a little honey or any sweetener. You can also drink it as it is. Do not add honey to hot liquids as you will lose its benefits.
• For best results, have this drink on an empty stomach in the morning and have breakfast after half an hour.
   

  Notes

  • Using a measuring spoon to measure all the ingredients is good.
  • Though this powder remains good for longer period, do not make huge quantities as it will not be fresh and you will not get the fresh aroma while drinking this tea.
  • For best results have it on an empty stomach first thing in the morning.
  • If you have acidity issues, do reduce pepper and ginger powder to half the quantity mentioned.
  • This tea is a good immunity booster and also helps people with respiratory issues especially asthma.
  • Anything in excess is not good. I would suggest taking a break of 2 to 3 days in between and restarting again. Listen to your body!!
  • The combination of right diet and exercise along with this tea is what will help you lose weight in a healthy manner in the long run. Not only does this spice help in losing weight, it keeps your body healthy.
  • Anything mentioned is just out of my personal experience and knowledge acquired. The results can vary from person to person depending on various other factors. If you have any health issues, please work with a registered dietician or nutritionist.

  This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     
  

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How to choose the right kind of footwear when suffering from diabetes

Choose the right footwear

Diabetes does not only mean fluctuation in the blood sugar level, it affects the person in numerous ways. Ths symptoms include frequent urination, feeling excessively hungry and thirsty, extreme fatigue, blurry vision and weight loss. Owing to its diverse symptoms only eating healthy foods is not enough to manage the symptoms of the disease. It is equally important to make the necessary lifestyle changes to live a healthy and long life.

Diabetes and foot problems

Fluctuations in blood sugar  also damages the nerves and vessels of the feet and for the same reason number of diabetes patients suffer from foot problems. This condition is called Neuropathy. It can cause you to lose all kind of sensation in your foot.



Some people may develop open sores at the bottom of their feet or may develop calluses or thick areas of hardened skin. Nerve damage can also change the shape of your feet and even wounds take longer to heal. That is why it is important to take special care of your foot when dealing with diabetes and seek medical help. Another way to take care of your foot when suffering from this problem is by wearing the right kind of shoes. It is believed that wearing some special kind of shoes available in the market can help to improve the condition by promoting healthy circulation in your feet. 

Choosing the right footwear

Wearing comfortable and well-fitted shoes is necessary and can make your feet healthy and manage the symptoms of diabetes. Here are a few things you must look for in your shoes:
Your shoes should be 1/4 to 1/2 inch deeper than normal shoes so that you do not feel uncomfortable when dealing with calluses or hammertoes.

Instead of pointed toes, buy the one with a spacious toe box. This will give enough room to your toes to move and reduce the chance of corns, calluses, and blisters.



Avoid high-heel and high-heeled shoes as they put excessive pressure on your foot. 

Do not buy any fancy, strappy and open toe shoes. The straps put pressure on certain points of your feet, which can easily cause blisters. Even slippers are not the best option. Wear laced shoes as they provides better support and fit your feet perfectly. 

Whenever planning to buy new shoes, do it at the end of the day. Our feet are swollen at the end and if your shoes fit in at that time, you would not have any problem later. 

Other ways to take care of your feet

Apart from wearing the right kind of shoes you also need to take care of feet to ensure that it is healthy. Here are a few things that you can do:

Check your feet every day. In case you develop any new sore or callous, consult your doctor.
Trim your toes nails regularly.

Exfoliate your feet with scrub regularly to smoothen your corns.

Wash your feet daily with warm water

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement