Wednesday, September 18, 2013

Red grapes and blueberries may boost immunity

Red grapes and blueberries may protect the body against illness by boosting the immune system, a new study has claimed.

Scientists examined the effects of 446 different chemical compounds on the immune system and identified two which had a significant impact - resveratrol found in red grapes and a compound called pterostilbene from blueberries.

Researchers  discovered that both of these compounds, which are called stilbenoids, worked in synergy with vitamin D and had a significant impact in raising the expression of the human cathelicidin antimicrobial peptide, or CAMP gene, that is involved in immune function.

Their synergy with vitamin D to increase CAMP gene expression was significant and intriguing. It's a pretty interesting interaction.

Resveratrol has been the subject of dozens of studies for a range of possible benefits, from improving cardiovascular health to fighting cancer and reducing inflammation.

This research is the first to show a clear synergy with vitamin D that increased CAMP expression by several times, scientists said.

The CAMP gene itself is also the subject of much study, as it has been shown to play a key role in the "innate" immune system, or the body's first line of defence and ability to combat bacterial infection.

The innate immune response is especially important as many antibiotics increasingly lose their effectiveness.

A strong link has been established between adequate vitamin D levels and the function of the CAMP gene, and the new research suggests that certain other compounds may play a role as well.

Stilbenoids are compounds produced by plants to fight infections, and in human biology appear to affect some of the signalling pathways that allow vitamin D to do its job, researchers said.

It appears that combining these compounds with vitamin D has considerably more biological impact than any of them would separately, they said.

ps- this is only for information, always consult you physician before having any particular food/ medication/exercise/other remedies.

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Sunday, May 26, 2013

Radioactive nanoparticles that target cancer cells developed

The  scientists cover the lutetium nano-particles with gold shells and attach targeting agents.

Researchers have found a way to create radioactive nano-

particles that target lymphoma tumour cells wherever they 

may be in the body.

Cancers of all types become most deadly when they 

metastasise and spread tumours throughout the body. Once 

cancer has reached this stage, it becomes very difficult for 

doctors to locate and treat the numerous tumours that can 

develop.

An associate professor of oncology stated that being able to 

target secondary tumours is vital to successfully treating 

patients with progressive cancers.

“Depending on the type of cancer, primary tumours usually 

are not the cause of death for cancer patients. If a cancer 

metastasises, or spreads creating hard-to-find tumours, it 

often becomes fatal. Having a way to identify and shrink 

these secondary tumours is of utmost importance when 

fighting to save people with these diseases,” he said.

In an effort to find a way to locate and kill secondary tumours, 

researchers have successfully created nano-particles made 

of a radioactive form of the element lutetium. The 

scientists then covered the lutetium nano-particles with gold 

shells and attached targeting agents.

In previous research, the researcher has already proven the 

effectiveness of similar targeting agents in mice and dogs 

suffering from tumours. In that research, the targeting agents 

were attached to single radioactive atoms that were 

introduced into the bodies of animals with cancer. The 

targeting agents were able to seek out the tumours existing 

within the animals, which were then revealed through radio-

imaging of those animals.

In their current research, the scientists have shown the 

targeting agents can deliver the new radioactive lutetium 

nano-particles to lymphoma tumour cells without attaching to 

and damaging healthy cells in the process.

A researcher said this is an important step toward developing 

therapies for lymphoma and other advanced-stage cancers.

“The ability to deliver multiple radioactive atoms to individual 

cancer cells should greatly increase our ability to selectively 

kill these cells. We are very optimistic about the synergy of 

combining the targeting strategy developed in the lab with our 

work on new radioactive nano-particles,” he said.

This study is an example of the collaborative research taking 

place. The early-stage results of this research are promising. 

If additional studies, including animal studies, are successful 

within the next few years, the researchers will request 

permission from the federal government to begin human drug 

development. After this status has been granted, researchers

may conduct human clinical trials with the hope of developing 

new treatments.


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Thursday, May 17, 2012

Anti-inflammatory herbs and spices



Try: Turmeric. Turmeric contains a powerful anti-inflammatory compound known as curcumin. (In fact, turmeric is sometimes simply called curcumin.) This deep yellow-gold spice has a smoky, peppery flavor and is used in curries and mustard. "It's such a powerful anti-inflammatory, it's one of the spices I recommend eating every day," says integrative nutritionist Beth Reardon, director of nutrition at Duke Integrative Medicine, part of the Duke University Health System, who adds it to almond milk with cinnamon and a touch of honey.
Other examples: Garlic, ginger, cinnamon, tart cherry, curry, rosemary. (Dried tart cherries, while not technically a spice or herb, are another antioxidant-superstar way to "spice up" other foods.)
Why: Several studies have shown an anti-inflammatory effect of turmeric on patients with rheumatoid arthritis. These spices and herbs help inhibit the formation of inflammatory prostaglandins and COX inhibitors (the same enzyme-inhibiting substances in medications such as Vioxx or Celebrex).

Try: Canned salmon. The fish highest in inflammation-busting omega-3 fatty acids, salmon, is available in cans year-round. Wild-caught is healthier than farm-raised salmon, which may contain toxic chemicals and antibiotics, depending on their feed and the conditions they're raised in.
Other examples: Cold-water fish that supply omega-3 fatty acids include black cod, tuna, sardines, halibut, mackerel, herring, and anchovies. And for protein don't overlook legumes and dried beans, such as lentils, soybeans, and black beans, and ancient grains including quinoa, millet, and spelt. Plant sources of omega-3s include pumpkin seeds, walnuts, and flaxseed.
Why: Replacing animal protein with proteins from fish increases your consumption of DHA and EPA, so-called "long chain" omega-3 fatty acids, which have been linked to improvement in symptoms of both osteoarthritis and rheumatoid arthritis. Plant sources provide also-essential "short-chain" omega-3 fatty acids.

Try: Coconut oil. Available in specialty groceries. coconut oil provides good fuel for the cells that line the gut, which is fundamental to proper immune system functioning. You can use coconut oil in cooking and baking where a light, slightly sweet flavor is desired, or to pop popcorn (another plant food high in antioxidants).
Other examples: Olive oil, grape-seed oil, avocados, ground flax, nut butters (especially almond, almond-flaxseed, cashew, or sunflower seed, which are less inflammatory than peanut butter), omega-3-fortified eggs.
Why: You'll be displacing unhealthy, omega-6 saturated fats (found in highly processed foods), which far outnumber good-for-you omega-3 fats in most American diets -- a backwards ratio that fans inflammation. Healthy fat sources fuel both proinflammatory hormones, which fight stresses to cells, and anti-inflammatory hormones, which regulate the healing process after a threat (injury or infection) is gone.

Try: Kale. It's fibrous, low in calories, rich in dozens of beneficial flavonoids, and is one of the most nutrient-dense greens. Chop it into vegetable- or bean-based soup, blend it in a smoothie, or add it to salad or pasta dishes. To bake kale chips, tear leaves into bite-sized pieces, sprinkle or spray on olive oil (one tablespoon per cookie sheet), and add some sea salt. "It's a pretty awesome vegetable,.
Other examples: Whole grains, beans, lentils, and all dark green, red, orange, yellow, blue, and purple fruits and vegetables -- the whole rainbow. Rule of thumb: The more intense the color, the more antioxidants are packed inside. But even whites (cauliflower, garlic, onion) and blacks (black beans) provide plenty of benefits.
Why: A plant-based diet emphasizing whole (unprocessed) foods "is like a force field, or sunglasses, protecting your lipid membranes and DNA from oxidative damage. Ideally, amp up the plant foods at the same time you eliminate refined and processed foods (such as white flour, sugar, and packaged goods like cakes, cookies, chips), which can raise blood glucose, increasing insulin production and, in turn, inflammation.
Variety is the key word, because the cumulative effect of many different nutrients is what creates the beneficial synergy.  "It really does take a village."
 Probiotics
Try: Greek yogurt. This thick type of yogurt packs more than twice the protein of regular yogurt, and it contains probiotics -- live microorganisms that help supplement the healthy bacteria already in your digestive tract. It's also a good source of vitamin D.
Other examples: Probiotics are also found in any yogurt containing live cultures (check the label for Lactobacillus acidophilus and L. bifidus, two common types) and in any fermented food -- such as kimchee, sauerkraut, and kefir.
Why: Probiotics help your gut preserve a healthy balance of good bacteria, which are often under siege from factors ranging from poor nutrition and stress to smoking and pollution. "A healthy population of bacteria needs a plant-based diet to survive -- it's its own biosystem that needs to be cultivated. This dairy food is another way to supplement that healthy ecosystem. It's especially beneficial after finishing a course of antibiotics, she says, which can disrupt the balance of healthy bacteria.
 Lots of water
Try: Green tea powder. Also called matcha, powdered green tea -- basically the tea leaves, finely ground -- provide the same powerful antioxidants that green tea beverages do, but in a more concentrated and versatile form. In steeped tea, the liquid contains the water-soluble antioxidants from the tea leaves, but in tea made from green tea powder, you're literally consuming the whole leaf. Stir it into water (hot or cold) for tea, or add to smoothies or lattes. It can even be added to baked goods or soups.
Other examples: Water, green tea. Black tea and coffee also contain anti-inflammatory properties, but in lesser amounts. However, their caffeine can help treat headache pain.
Why: The vital organs and blood supply are composed of as much as 90 percent water. "Water is needed by the liver to help detoxify chemicals and the other compounds we come in contact with," Reardon says. Water helps all the body's processes work, right down at the cellular level.





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