New Hope for Cell Damage and Repair

If the stories in the media are to be believed, the process of tissue nanotransfection, in which skin cells are turned into things like blood vessels by placing them on a small nanochip, then a revolution in medical science will soon be underway.

 The researchers have dubbed the new technique as TNT for tissue nanotransfection, a process that is so revolutionary that is seems to come out of science fiction. Skin cells from the patient are bombarded electrically with DNA to become nerves, blood vessels, and other complex parts of the body. There is already talk of treatments for Parkinson's disease, Diabetes, and Altzheimer's. Similarly, there is the possibility of treating traumatic injuries or those requiring reconstruction, so that blood can flow to organs or damaged limbs. 

 

Like the Frankenstein Film, but on a Nano Scale!

Imagine fixing the human heart by using a microchip. If the promise of TNT is fulfilled, this is just one of the many new treatments that will be possible.

Trials in Animals are promising

The treatment has become a media sensation with a great deal of interest among medical professionals. The chip itself was used to create new blood vessels to restore blood flow to a mouse's damaged limb, showing promise for the same type of treatment in humans. Furthermore, the ability to make cells with a patient's own DNA will circumvent rejection.

Pioneering research  may be creating a whole new field in medicine, and ways for people to heal quickly from traumatic injury, stay healthier longer, and reduce medical costs associated with long-term treatment. In many ways the chip appears to have the same promise as stem cell research, which is far more controversial. 

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New device could heal organs with a touch

Scientists have developed a device that can convert skin
cells in the body into any other cell type with just a touch, an advance that may help repair injured tissues, blood vessels and nerves.

Researchers developed a new technology called Tissue Nanotransfection (TNT) and tested it on mice and pigs.They were able to re-programme skin cells to become vascular cells in badly injured legs that lacked blood flow.

Within a week, active blood vessels appeared in the injured leg, and by the second week, the leg was saved. In lab tests, the technology was able to re-programme skin cells in the live body into nerve cells that were injected into brain-injured mice to help them recover from stroke.

"By using our novel nanochip technology, injured or compromised organs can be replaced. We have shown that skin is a fertile land where we can grow the elements of any organ that is declining," said one of the researcher.

"This is difficult to imagine, but it is achievable, successfully working about 98 per cent of the time. With this technology, we can convert skin cells into elements of any organ with just one touch," said the researcher."This process only takes less than a second and is non- invasive, and then you're off. The chip does not stay with you, and the reprogramming of the cell starts," he said.

TNT technology has two major components: a nanotechnology-based chip designed to deliver cargo to adult cells in the live body; and the design of specific biological cargo for cell conversion. This cargo, when delivered using the chip, converts an adult cell from one type to another, said an assistant professor.

TNT does not require any laboratory-based procedures and may be implemented at the point of care. The procedure is also non-invasive.The cargo is delivered by zapping the device with a small electrical charge that is barely felt by the patient.

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