Woman Becomes the First Known Case of a Person Urinating Alcohol

Pittsburgh woman has become the first person to be diagnosed with a rare syndrome which causes alcohol to brew in the bladder due to the fermentation of yeast and sugar.

The anonymous patient, 61, has diabetes and liver cirrhosis and was on the donor waiting list for a liver transplant. However, she was taken off the list and referred to alcohol abuse treatment instead.

Doctors thought her problem was alcohol addiction; however, the patient denied ever drinking alcohol.

The doctors were understandably skeptical since the repeated urine tests for alcohol showed positive. As the next step, the doctors ran a blood test which surprisingly showed no alcohol in her blood.

In order to crack the mystery, Kenichi Tamama of the University of Pittsburgh Medical Center in Pennysylvania conducted some basic tests and saw that the woman’s urine contained yeast.

It is not unusual for the urine to have yeast. However, it is also known that diabetes causes a high amount of sugar in the urine. In order to see these two components in action, Tamama ran tests on her urine and discovered that the yeast was fermenting sugar in her bladder.

The doctors named the condition “urinary auto-brewery syndrome”. This yeast, identified as Candida glabrata, is normally found in the body and it is related to what breweries use.

The process that resulted in alcohol is almost exactly the same as the one used by beer makers. Needless to say, this is extraordinary since now we know that the same process can also happen in the human body.

All in all, peeing alcohol might not be that big of a deal after all. According to Tamama, it doesn't affect the patient's health. Efforts were made to eliminate the yeast, but they weren't successful due to the patient’s diabetes.

According to the paper, the patient was reconsidered for liver transplantation; however, her whereabouts are unknown at the moment.

The findings were reported in Annals of Internal Medicine.


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Taking antibiotics before liver transplants leads to better outcomes

A recent study has found that administering antibiotics to mice for 10 days prior to a liver transplant leads to better liver function after surgery, and the same holds true for human beings too.

After concluding the experiment in mice, scientists studied data from liver transplants performed between October 2013 and August 2015 revealing that the same phenomenon appears to hold true in humans.

The statistics from human patients even demonstrated that the people who were in worse health prior to their surgeries but received pre-surgery antibiotics fared better after their transplants than the patients who were healthier prior to their surgeries but did not receive antibiotics.

The researchers concluded that the antibiotics inhibited bacteria that cause inflammation, which in turn can lead to organ rejection.

Specifically, they found that in mice and humans, the treatment prior to a transplant reduced the damage that could occur when blood flow is restored to the liver after a period of time without oxygen; and it reduced inflammation and cell damage while accelerating the removal of damaged cells.

“The livers in the mice that received antibiotics were protected against transplant damage, as well as rejection later on because the antibiotics modulated their host microbiomes, which in turn stimulated cell protection,” Kupiec-Weglinski said.

To substantiate the effect of the antibiotics, the researchers then transplanted faecal matter from the untreated mice into those that had been given the medication.

The mice that received the faecal transplants suffered inflammatory damage to their livers, despite the fact that they had been given antibiotics earlier in the experiment.

“That showed that antibiotic-mediated benefits clearly relate to the microbiota,” Kupiec-Weglinski said.

The data on the UCLA patients covered 264 people who had received liver transplants — 156 who, because they were sicker before their surgeries received antibiotics for 10 or more days prior to the transplant, and 108 who were given antibiotics for less than 10 days, or not at all prior to surgery.

The researchers then narrowed their focus to human patients who had been given one specific antibiotic, rifaximin, prior to the transplants.

They found that in patients that received rifaximin, which stays in the bowel and has a low risk for inducing bacterial resistance, early liver failure was significantly delayed or stopped.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     
https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement 

Taking antibiotics before liver transplants leads to better outcomes

A recent study has found that administering antibiotics to mice for 10 days prior to a liver transplant leads to better liver function after surgery, and the same holds true for human beings too.

After concluding the experiment in mice, scientists studied data from liver transplants performed between October 2013 and August 2015 revealing that the same phenomenon appears to hold true in humans.

The statistics from human patients even demonstrated that the people who were in worse health prior to their surgeries but received pre-surgery antibiotics fared better after their transplants than the patients who were healthier prior to their surgeries but did not receive antibiotics.

The researchers concluded that the antibiotics inhibited bacteria that cause inflammation, which in turn can lead to organ rejection.

Specifically, they found that in mice and humans, the treatment prior to a transplant reduced the damage that could occur when blood flow is restored to the liver after a period of time without oxygen; and it reduced inflammation and cell damage while accelerating the removal of damaged cells.

“The livers in the mice that received antibiotics were protected against transplant damage, as well as rejection later on because the antibiotics modulated their host microbiomes, which in turn stimulated cell protection,” the researcher said.

To substantiate the effect of the antibiotics, the researchers then transplanted faecal matter from the untreated mice into those that had been given the medication.

The mice that received the faecal transplants suffered inflammatory damage to their livers, despite the fact that they had been given antibiotics earlier in the experiment.

“That showed that antibiotic-mediated benefits clearly relate to the microbiota,” the researcher said.

The data on the patients covered 264 people who had received liver transplants — 156 who, because they were sicker before their surgeries received antibiotics for 10 or more days prior to the transplant, and 108 who were given antibiotics for less than 10 days, or not at all prior to surgery.

The researchers then narrowed their focus to human patients who had been given one specific antibiotic, rifaximin, prior to the transplants.

They found that in patients that received rifaximin, which stays in the bowel and has a low risk for inducing bacterial resistance, early liver failure was significantly delayed or stopped.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                  https:// kneereplacement-stickclub.blogspot.com/                                                                      FOR CROCHET DESIGNS                                                                                                    

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Living-donor liver transplant offers numerous advantages over deceased donor

A recent study has highlighted the advantages of living-donor liver transplant over deceased-donor.
According to the study, a living-donor liver transplant offers numerous advantages over deceased-donor transplant, including better 3 year survival rates for patients and lower costs.

The study, highlights living donation as a viable, if not preferable, option for more than 14,000 people currently on the waiting list, as well as many more who never qualify to be on the list under current allocation rules.

About 8,000 liver transplants are performed each year according to  the Organ Procurement and Transplantation Network, and living-donor liver transplant comprises less than 5% of that total.
Additionally, about 25% of people on the waiting list die each year waiting for a transplant, and those who eventually receive a transplant often have a lengthy period on the waiting list, resulting in poorer health at the time of transplant.

The consequences for patients on the waiting list can mean the difference netween life and eath because the longer they're waiting, the sicker they become. Living-donor liver transplants, in tandem with deceased donor liver transplants, represents an opportunity to significantly decrease the risk of wait-list mortality, and gives us the ability to transplant a person sooner, said the lead author of the study.

The retrospective review of 245 adult living donor liver transplants and 592 deceased-donor liver transplants performed over the last 10 years compared survival rates and other outcomes such as recovery times, complications, costs and resource utilisation. The patients were followed for at least two years post-transplant.

Of those comparisons, 3-year patient survival outcomes were superior in living-donor liver transplant recipients - 86 % versus 80 %. Living-donor liver transplant recipients overall had about a 5% survival advantage over deceased donor recipients.

Patients who received a liver from a living donor had a hospital stay of 11 days as compared to 13 days for those who received a liver from a deceased donor, had less likelihood of intra-operative blood transfusion (53 % compared to 78%) and less likelihood of the need for post-transplant dialysis ( 1.6% versus 7.4 %). Hospital costs related to transplant also were 29.5 % lower for living donor recipients. For the living-liver donor, there were no mortalities observed, and the overall complication rate was 20 %.

Living-donor liver transplant should be considered the first and best option for most patients with liver disease, he said. It is not only an option for those on the waiting list but could perhaps offset the fact that not everyone who may benefit from transplant qualifies  to receive a deceased-donor transplant based on today's current rules of allocation.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                  https:// kneereplacement-stickclub.blogspot.com/                                                                      FOR CROCHET DESIGNS                                                                                                                                                                                     https://gscrochetdesigns.blogspot.com