Paracetamol during pregnancy may delay daughters’ language skills

Women who consume acetaminophen — also known as paracetamol and widely used to reduce a high fever or relieve pain — during early pregnancy are six times more likely to see delay in their daughters’ language skills, warns a new study.

Acetaminophen is the active ingredient in Tylenol and hundreds of over-the-counter and prescription medicines.

The maternal intake of acetaminophen saw a reduction in the intelligence quotient level along with increasing language delay, defined as the use of lesser than 50 words, by the kids.

The communication delay affected boys at the same time, but was more prevalent among the girls, the study showed.

“Given the prevalence of prenatal acetaminophen use and the importance of language development, our findings, if replicated, suggest that pregnant women should limit their use of this analgesic during pregnancy,” said a Professor.

“It’s important for us to look at language development because it has shown to be predictive of other neurodevelopmental problems in children,” the Prof. added.

The study,  examined 754 women, who were in eight-13 weeks of pregnancy.

Researchers asked participants to report the number of acetaminophen tablets they had taken between conception and enrollment, and tested the acetaminophen concentration in their urine at enrollment.

Both the number of tablets and concentration in urine were associated with a significant increase in language delay in girls, with a slight decrease in boys.

Previous studies have found that the over exposure to the pain relieving drug during pregnancy also damages the fertility of the daughters.

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Early intervention of Autism leads to fewer symptoms later

Early intervention for autism leads to fewer autism symptoms later in childhood. Unfortunately, autism diagnosis usually doesn’t occur until after three years of age. To improve time to therapy, researchers are looking for clues to diagnose autism as early as possible.

What’s new: In a large medical record study of 3,911 children with autism, researchers found that 38 medical conditions were associated with a future autism diagnosis. Medical conditions that showed the strongest link to autism included:

• Language delays
• Learning and cognitive disorders
• Global delays (significant delay in two or more areas of development)
• Motor delays
• Attention Deficit/Hyperactivity Disorder (ADHD)
• Anxiety disorders
• Cerebral palsy
• Epilepsy and recurrent seizures
• Disorders of the central nervous system

A combination of language delay with global delay most strongly correlated with an autism diagnosis. In total, the researchers identified 14 combinations of medical conditions that were associated with a future autism diagnosis.
Why it’s important: This study offers evidence that early life medical conditions could help doctors identify children who need close follow-up for autism assessment. Many of these medical conditions appear a year or more before autism symptoms become apparent.

  Autism Spectrum Disorder (ASD) is a group of conditions with common social and behavioral deficits. Trained specialists use behavioral tests to diagnose ASD. Although some ASD traits may appear as early as infancy, the average age for ASD diagnosis is about 4 years old. Despite increase in research funding and media focus, no molecular, genetic or brain imaging tests are available for diagnosing autism. 

At present, diagnosing ASD requires a comprehensive approach that includes systematic and structured observation of a child by trained clinicians. Guidelines for ASD diagnosis are set forth by various institutions.

There are two stages for diagnosing autism:

1. The first stage is screening, an easy-to-use, general method that identifies a potential risk for developing ASD.
2. The second stage is diagnostics, an in-depth examination that requires the assessment of cognition, linguistics, and motor skills by a qualified medical team to accurately diagnose the developmental disorder and the degree of the disorder.

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