Eyes and Vision Facts and Information

The human eye is one of the most complex organs we have in our body and enables the most important sense in our nature: vision. It provides food for our memory, a sharp definition of the world around us, and astounding capabilities that are beyond unbelievable. If you're curious to know more about the human eye (and you certainly should be), here are 17 facts that will boggle your mind.

 

 

 

 

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Australian researchers discover how a baby's sex is determined

While it is known that the sex of a baby is determined by its chromosome make-up at conception, new research has identified a "regulator" that increases or decreases the activity of genes which decide if we become male or female.

"These regulatory segments of DNA are called enhancers," said lead author of the study.

"If these enhancers that control testis genes are disrupted it may lead to a baby being born with a disorder of sex development," Sinclair said. 

While an embryo with two X chromosomes will become a girl, an embryo with an X-Y combination results in a boy. But the Y chromosome carries a critical gene, called SRY, which acts on another gene called SOX9 to start the development of testes in the embryo, explained a researcher.

"High levels of the SOX9 gene are needed for normal testis development," he added. 

This study,  sought to understand how the SOX9 gene was regulated by enhancers and whether disruption of the enhancers would result in disorders of sex development.

"We discovered three enhancers that, together ensure the SOX9 gene is turned on to a high level in an XY embryo, leading to normal testis and male development," he said.

"Importantly, we identified XX patients who would normally have ovaries and be female but carried extra copies of these enhancers, (high levels of SOX9) and instead developed testes," Sinclair said.
"In addition, we found XY patients who had lost these SOX9 enhancers, (low levels of SOX9) and developed ovaries instead of testes," Sinclair added.

Croft said human sex reversal such as seen in these cases is caused by gain or loss of these vital enhancers that regulate the SOX9 gene.

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