Cancer risk in psoriatic patients

A new study published in February 2020 in the journal JAMA Dermatology reports that there is a 21% increased risk of cancer in patients with psoriasis, but not with psoriatic arthritis alone.

What is psoriasis?

Psoriasis is a chronic inflammatory disease that affects the skin and the joints, mediated by the T immune cells. The skin cells typically travel from the basal layer of the epidermis, where they are generated to the most superficial layer. By the time they reach the top layer, they have differentiated completely and are dead skin cells or keratinocytes, filled with the skin protein called keratin.
However, in psoriasis, the basal cells speed up on their journey to the top layer, and as a result, they reach it in an immature state, pushing the mature keratinocytes off. The skin, therefore, appears red, tender, cracked, and peeling.

Earlier studies have found that patients with psoriasis are at an increased risk of cancer compared to people without the condition or the general population. Psoriasis is also associated with smoking and drinking; two factors also linked to cancer risk. It is already known that lymphomas and keratinocyte cancers are present at a higher rate in patients with psoriasis.

Psoriasis on elbow.

Secondly, several new biologic drugs have been introduced for the treatment of psoriasis, but biologic agents have a risk of cancer. However, whether these agents confer a risk of cancer independent of the disease itself is an unanswered question.

The study

The current study is a systematic review and meta-analysis to find the risk of cancer in two conditions, namely, psoriasis and psoriatic arthritis, in addition to the risk of specific cancers. The researchers also aimed at finding the risk of cancer in psoriasis patients who are on biologic agents rather than conventional drugs.

The researchers looked at 112 studies in which over 2 million patients with psoriasis or psoriatic arthritis were involved, and in which cancer outcomes were reported. They analyzed the risk of cancer overall, and certain cancers specifically.

The findings

The study showed an almost 4.8% prevalence of cancer in psoriasis patients, with an incidence rate (IR) of nearly 11.8 per 1000 person-years. If keratinocyte cancer is excluded, the prevalence and IR are 4% and 7.6, respectively.

Eight studies showed a higher and two studies at a lower risk of cancer in psoriasis patients. The overall risk was 20% higher, or 14% higher after excluding keratinocyte cancer.

Keratinocyte cancer occurred in 2.5% of patients with psoriasis, with an IR of 4.4. The risk for this cancer was more than 2.28 times higher in psoriasis patients compared to others. For melanoma, lymphoma, and non-Hodgkin lymphoma, the risk was 13%, 56%, and 48% higher, respectively. For Hodgkin lymphoma, the risk was 87% higher.

Concerning breast cancer and colorectal cancer, the risk was not higher in these patients. However, psoriasis patients were at a 26% higher risk of lung cancer.

Overall, there was no significant change in the risk of cancer for patients on biological agents, nor when keratinocyte cancer or lymphomas were considered. The same was the case with psoriatic arthritis as well, except for breast cancer, which was significantly higher in three studies.

Implications

The current study includes over twice the number of studies as the last comprehensive review in 2013, including newer studies with a more significant number of participants. Yet the findings remain the same overall, supporting the existence of an association between psoriasis and cancer, but not psoriatic arthritis.

Keratinocyte cancer is linked to sunlight exposure, and the risk is significantly increased in patients with psoriasis who are on PUVA therapy, involving exposure to ultraviolet rays. The highest risk is for squamous cell carcinoma. Other factors that have been suggested are more extended periods spent in the sunlight and treatment with UVB irradiation and with coaltar, which are both risk factors for keratinocyte cancer.

The increased risk of lymphoma may be due to the higher risk of cutaneous T-cell lymphoma, which is markedly more common in people with severe psoriasis. This might be due to chronic activation of the immune system, the authors speculate.

Lifestyle factors like alcohol and smoking are also linked to the higher risk of psoriasis and also of cancer in these patients. However, other factors are also involved, and these need to be identified.

With many different types of cancer occurring at a higher rate in patients with psoriasis, it is essential that doctors who treat such patients be aware that such risks exist. Especially in the case of lymphomas, any therapy for psoriasis which activates the immune system could also result in increased lymphoma activity. More research is required to assess the risk with the use of biologic agents and in psoriatic arthritis.

This is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.     

https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement 

20 Everyday Habits That Increase Your Cancer Risk

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Here are some important tips that can help you lead a cancer-free life.

Don't let these subtle signs become something serious. It's time to catch these commonly overlooked symptoms of cancer before they catch you.

So many new potential causes of cancer pop up every month that it’s hard to know what to believe and what to brush off. Just this week, a study in the journal Nature found asparagine — a chemical compound in asparagus — might even be linked to breast cancer. (Don’t worry, though — more tests still need to be done before you give up the veggie for good!) 

Because cancer is one of the leading causes of death worldwide and it’s being predicted 22 million new cases will come about within the next 20 years, it’s more important than ever to be aware of things you’re doing every day that can increase your risk, starting with these 20 common habits.

1.Eating Charred Meat

When people eat meat, they tend to like it charred. The big issue is that cooking meat at high temps can form chemicals that cause changes in the DNA that could increase your risk of cancer, says the NCI.

If you do cook meat, make sure it’s not getting over-done — or, ditch it altogether. A 12-year-long study published in the journal Nature that involved 61,566 participants found the incidence of cancer was much lower with vegetarians compared to meat-eaters.

2. Over-serving Yourself

This one is going to be super disappointing, just FYI. Having a drink here and there is totally fine, but when you’re downing alcohol on the daily — 1 or 2 drinks per day, to be exact — that’s when problems arise. According to the doctors, over-drinking has been linked to a higher risk of throat, liver, colon, and breast cancer. That doesn’t mean you have to skip hanging out with friends who drink: Just limit your intake by sipping on something non-alcoholic instead.

3.Using a Plastic Water Bottle

If your go-to water bottle is plastic, you might want to switch to something that’s glass, steel, or ceramic. According to oncologists, some research suggests plastic beverage containers contain potentially harmful chemicals like BPA, a weak synthetic hormone that could mess with your body’s hormonal balance, potentially causing breast cancer. There are still mixed opinions on whether plastic bottles actually cause cancer or not, but steer clear just in case.

4.Sleeping With Your Phone Next to Your Head

You might like falling asleep to your favorite podcast, but get your phone as far away from your head as possible while you’re catching sleep. In December, the health experts came out with guidelines to minimize people’s exposure to the radio-frequency energy cell phones put out due to research on its link to brain cancer, among other issues. So put your phone in another room.

5.Sitting Around Too Much

Some days are super lazy, and others are go-go-go. Those times when you’re sitting around relaxing probably feel great; the only issue is too much sitting can put you at risk of cancer. In 2014, German scientists analyzed data from 43 studies and found two additional hours of sedentary behavior a day could put you at an 8 percent increased risk of colon cancer, 10 percent increased risk of endometrial cancer, and 6 percent increased risk of lung cancer.

6.Doing Laundry

Doing your laundry seems harmless enough, right? Well, not so much. According to the Environmental Working Group, some brand-name liquid laundry detergent contains 1,4-dioxane, a chemical that could potentially be cancerous. In past research, animals exposed to the chemical had higher rates of liver tumors than those who didn’t, so it’s something to be weary of. Maybe get the natural stuff instead.

7. Using Deodorant

If you haven’t ventured into natural deodorants yet, this fact will make you stock up immediately. Although the expert says no clear link has been made between deodorant and breast cancer at this time, research has suggested the aluminum compounds in deodorant that keep you from getting sweaty could cause damage after being absorbed by the skin, changing the estrogen receptors and potentially leading to breast cancer.

8. Skipping Out on Flossing

Are you keeping up with your oral hygiene? Brushing, flossing, and using mouthwash is essential to making your teeth happy — and if you skip out and don’t get them the attention they deserve, you could put yourself at risk of developing cancer. A January 2018 study  found gum disease is associated with a 24 percent increase in both lung and colorectal cancer, meaning you need to start taking care of your mouth ASAP.

9. Sleeping With the TV On

Falling asleep to the sound of the TV might be the only way you can get yourself to pass out. Unfortunately, all that artificial light at night isn’t too great for your body. A 2010 study in the journal Environmental Health Perspectives found it’s been linked to both breast and prostate cancer due to messing with your melatonin, the hormone that promotes sleep.

10. Using Scented Candles

There’s something so soothing about scented candles. They can relax you almost immediately in the moment but could do a whole lot of damage down the road. Unfortunately, scented candles are full of potentially dangerous chemicals like benzene and toluene and breathing them in regularly could increase your risk of cancer, says the environmentalists.

11.Eating Microwave Popcorn

It’s quick, easy, and delicious — so what’s the problem with microwave popcorn? Well, not only can the chemical diacetyl — AKA a butter flavoring in the mix — lead to lung issues from breathing it in, but the Dr. said, it can also lead to bladder cancer. It might take a little more effort to make your popcorn from scratch, but you’ll thank yourself later for taking the extra time.

12.Using Baby Powder

If you use baby powder often, this is going to make you want to toss it out for good immediately: A 2010 study published found using the product — also called talcum powder — can increase the risk of endometrial cancer in women by 24 percent when used on the perineal area. Yeah, that’s a lot.

13.Using Makeup and Skincare That Contains Parabens

Parabens are sneaky little guys. And, they can also be dangerous. Research has shown the chemical compounds — which are used as preservatives in a countless number of makeup and skincare products — are easily absorbed through the skin and can cause a spike in the growth of breast cancer cells. Now with the natural beauty movement taking off, there’s no reason to put products on your body that have any sort of potentially harmful chemical.

14.Eating Processed Meat

Move over, hot dogs: Veggie dogs might be the only safe summer BBQ option when it comes to preventing cancer. According to the cancer speccialists, processed meat has officially been classified as a carcinogen. In fact, eating just 1.8 ounces of processed meat a day can increase your risk of colorectal cancer by 18 percent. In addition, it can also cause pancreatic and prostate cancer.

15.Breathing in Pollution

Yep, even the simple act of breathing can increase your cancer risk. It’s been known for quite a while that air pollution can do some major harm, and according to the World Health Organization, the cancer-causing substances in the air caused 223,000 deaths from lung cancer in 2010 alone. In addition, it’s also been linked to an increased risk of bladder cancer.

16.Not Wearing Sunscreen

Most people don’t think they don’t need to wear sunscreen unless they’re going to the beach. That’s completely false, though — and it’s leading to a whole lot of skin cancer cases. According to the Skin cancer Foundation, you should slather on SPF year-round, no matter the season or the weather, to decrease your risk. Remember: regularly wearing sunscreen is one of the 20 best ways to have your best skin.

17.Working the Night Shift

Recent reports estimate three million Americans now work the night shift. It might not seem like working when it’s dark out and sleeping when it’s light would do any major bodily harm, but a 2013 study published in the British Medical Journal found the graveyard shift can increase the risk of breast cancer, most likely due to melatonin suppression — especially in those who have done so for a long time.

18.Pumping Gas

Filling up your car with gas is something most people do on a regular basis. Unfortunately, one common mistake could be increasing your cancer risk. Adding just a little bit more gas in after your nozzle clicks off might not seem like a big deal, but according to the EPA and President’s Cancer Panel, that extra fuel could mess with the pump’s vapor recovery system, potentially releasing cancer-causing chemicals like benzene in the air.

19.You’re Not Drinking Enough Water

Drinking plenty of water throughout the day keeps everything in your body working properly. One thing it also does it dilute harmful substances in the urine, potentially helping reduce the risk of bladder cancer due to flushing them through your system faster, says the doctor.

20.Skip the Dry Cleaner

Is getting freshly-cleaned clothes via the dry cleaner worth increasing your risk of cancer? Probably not. Reports from the EPA have found perchloroethylene or “perc” — a chemical used by the majority of dry cleaners in the U.S. — could cause leukemia, as well as liver and kidney cancers. Look for a business that doesn’t use harmful chemicals or skip out altogether.



this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   
https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement              

Fitness level impacts cancer risk and outcomes

In a recent study, researchers have revealed that fit adults have the lowest risk of developing lung and colorectal cancer. Also, individuals who developed the cancers, those who had high fitness levels before their cancer diagnosis, were less likely to die compared with those who had low fitness levels.

There is limited data on the relationship between cardiorespiratory fitness and lung and colorectal cancer risk and mortality. To investigate, researchers studied 49,143 adults who underwent exercise stress testing from 1991-2009 and were followed for a median of 7.7 years.

The study represented the largest of its kind, as well as the first of its kind, to involve women and a large percentage of non-white individuals. Those in the highest fitness category had a 77 per cent decreased the risk of developing lung cancer and a 61 per cent decreased the risk of developing colorectal cancer.

Among individuals who developed lung cancer, those with the highest fitness had a 44 per cent decreased the risk of dying during follow-up; and among adults who developed colorectal cancer; those with the highest fitness had an 89 per cent decreased risk.

"Our findings are one of the first, largest, and most diverse cohorts to look at the impact of fitness on cancer outcomes," said the Dr.

"Fitness testing is commonly done today for many people in conjunction with their doctors. Many people might already have these results and can be informed about the association of fitness with cancer risk in addition to what fitness levels mean for other conditions, like heart disease," she added.

Additional studies are needed to expand on these results and to determine if improving fitness can influence risk and mortality rates of cancer.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/    

                                                                                                                                                     FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                  https:// kneereplacement-stickclub.blogspot.com/  

         

                   FOR CROCHET DESIGNS                                                                                                                                                                                                  https://gscrochetdesigns.blogspot.com

Are your dentures irritating you? If ill-fitting, they can cause cancer

Chronic irritation in the mouth resulting from ill-fitting dentures can cause oral cancer, warn researchers.

About 1,00,000 new cases of oral cancer are detected in India every year and it also leads to about 50,000 deaths annually.

“Chronic mucosal irritation resulting from ill-fitting dentures may be considered a risk factor for the development of oral cancer, such cancers occur commonly over the lateral border of the tongue,” said the research conducted by Hitesh Rajendra Singhvi, Akshat Malik and Pankaj Chaturvedi from the Department of Head and Neck Oncology at Tata Memorial Centre in Mumbai.

The doctors, however, said that no association has been proven between the duration of denture use and cancer formation.

Five-year survival of patients with early oral cancer is between 55% and 60% and it decreases to 30% and 40% in cases of advanced oral cancer, it said.

 The doctors reached the conclusion after reviewing 22 studies from across the world exploring links between mucosal trauma and cancer.

Nearly 80% of these cancers are associated with the use of tobacco, areca nut (supari), smoking and alcohol consumption. However, nearly 10% patients of oral cancer may not have history of such addictions.

A mucosa is a membrane that lines various cavities in the body and surrounds internal organs. Dentures are removable appliances that can replace missing teeth.

The doctors said that as per recent data from the Dental Council of India, there are about 1.5 lakh registered dentists for a population of about 1.3 billions, out of which 72% live in villages which remain deprived from dental care.

Among many reasons, low level of awareness among the population and the care providers even, has led to continued neglect of dental care.
 

this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on. 
https://gscrochetdesigns.blogspot.com. one can see my crochet creations  
htps://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes 
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement

Exercise scores over diet in lowering cancer risk

Are you on a strict diet to reduce body fat that may also help lower breast cancer risk? Better take up exercise as researchers have found that physical activity offers additional benefit, beyond the effect of weight loss in reducing cancer risk.

Both exercising and eating better are thought to reduce women's risk of breast cancer by decreasing body fat and levels of the sex hormones related to breast cancer.

"Exercise has a stronger effect on breast cancers fuelled by hormones, compared to dieting, and also offers additional benefits such as preserving lean body mass," said Anne Maria May from University Medical Center Utrecht in the Netherlands.

"Exercise is the preferred weight loss strategy to decrease breast cancer risk," May added.

The study involved about 240 overweight women, aged 50 to 69, and they were set a goal to lose five to six kgs over 16 weeks.

By the end of the study, women in both the exercising and dieting groups achieved their weight-loss goals, but the exercising participants preserved their lean body mass (which includes muscles and bones), and reduced more of their body fat, compared with the dieting participants.

Those who exercised also reduced their levels of estrogen (a potential risk factor for breast cancer) more than dieting participants did and the exercising women showed decreases in all types of estrogen in the body, whereas women in the diet group showed a decrease in only one type of estrogen. 

 

 

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.

PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-

HTTP:GSEASYRECIPES.BLOGSPOT.COM/

FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-

HTTP://KNEE REPLACEMENT-STICK CLUB.BLOGSPOT.COM/

FOR CROCHET DESIGNS

HTTP://MY CROCHET CREATIONS.BLOGSPOT.COM