Heart disease risk begins in the womb

Heart disease is the greatest killer in the world today, and it is widely accepted that our genes interact with traditional lifestyle risk factors, such as smoking, obesity and/or a sedentary life to promote an increased risk of cardiovascular disease. However, a new study in sheep, finds that offspring whose mothers had a complicated pregnancy may be at greater risk of heart disease in later life, suggesting that our cards may be marked even before we are born. 

In addition to the effects of adult lifestyle, there is already evidence that the gene-environment interaction before birth may be just as, if not more, important in "programming" future heart health and heart disease. For instance, human studies in siblings show that children born to a mother who was obese during pregnancy are at greater risk of heart disease than siblings born to the same mother after bariatric surgery to reduce maternal obesity. Such studies have provided strong evidence in humans that the environment experienced during critical periods of development can directly influence long-term cardiovascular health and heart disease risk.

The new research shows that adult offspring from pregnancies complicated by chronic hypoxia have increased indicators of cardiovascular disease, such as high blood pressure and stiffer blood vessels. Chronic hypoxia or lower-than-normal oxygen levels in the developing baby within the womb is one of the most common outcomes of complicated pregnancy in humans. It occurs as a result of problems within the placenta, as can occur in preeclampsia, gestational diabetes or maternal smoking.

The study, used pregnant sheep to show that maternal treatment with the antioxidant vitamin C during a complicated pregnancy could protect the adult offspring from developing hypertension and heart disease. The work therefore not only provides evidence that a prenatal influence on later heart disease in the offspring is indeed possible, but also shows the potential to protect against it by "bringing preventative medicine back into the womb," as the first author of the study, puts it.

It turns out that vitamin C is a comparatively weak antioxidant, and while the Cambridge study provides a proof-of-principle, future work will focus on identifying alternative antioxidant therapies that could prove more effective in human clinical practice.

"Our discoveries emphasise that when considering strategies to reduce the overall burden of heart disease, much greater attention to prevention rather than treatment is required. Treatment should start as early as possible during the developmental trajectory, rather than waiting until adulthood when the disease process has become irreversible," the Prof. added. The work draws attention to a new way of thinking about heart disease with a much longer-term perspective, focusing on prevention rather than treatment. 

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Autism may begin in the womb

Conditions for autism may develop even before birth, in the second and third trimester of pregnancy, a new study has found.

The study points to a disruption in the development of cortex, the outer layers of the brain which happens during the second and third trimester.

For the study that involved post-mortem brain tissue, researchers examined donated samples from 11 children, aged between 2 and 16, with autism and equal number of children without the condition.

They used special techniques to detect and visualise specific types of neurons in the brain's outer layer.

The scientists discovered dense patches in the cortex containing irregular shaped neurons residing in the wrong cortical layers, according to media reports.

These patches were 5 to 7 millimetres (about 0.2 inches) long and were found in the frontal and temporal cortex of 10 of the 11 children with autism but only one of the 11 unaffected children, the study claimed.

"These patches are not like a lesion, or loss of cells. The cells are there, but they haven't become what they were supposed to, in the layer they were supposed to be in," said Eric Courchesne, a professor of neuroscience in University of California, San Diego.

The patches were found in frontal and temporal cortex, areas that are important for social interaction and language, he added.

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