Hypertension can hinder clearance of waste molecules of brain

As part of a recent study, researchers have found that high blood pressure may affect conditions such as Alzheimer's disease by interfering with the brain's waste management system.

According to the findings, hypertension causes stiffening and elasticity loss in blood vessels, which hinders the clearance of waste molecules from the brain. Using a rat model of hypertension, a team of researchers, studied how the condition affects the movement of cerebrospinal fluid into and interstitial fluid out of brain cells.

The researchers tracked the flow of cerebrospinal fluid and found that the hypertensive rats exhibited larger ventricles, decreased brain volume, and impaired fluid transport.

They concluded that hypertension interferes with the clearance of macro-molecules from the brain, such as the Alzheimer's pathology protein b-amyloid. Treatments targeting hypertension could, in turn, reduce b-amyloid buildup and delay the onset of Alzheimer's disease.

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Menopause symptoms ---may increase cardiovascular disease risk

Menopause, associated with frequent and severe symptoms such as sleep disturbance, hot flashes and depression, may increase the risk of developing cardiovascular disease (CVD), a study says. The study found that menopause transition is marked with a number of adverse health effects, including hot flashes and depression to vascular aging, which is typically seen as artery stiffening and endothelial dysfunction.

In this study, the frequency, but not severity, of hot flashes was specifically associated with greater arterial stiffening and reduced endothelial function.

“Perimenopausal and early menopausal women are more vulnerable to increased risk of cardiovascular disease,” said a researcher.

“With fluctuating and then declining estrogen during the menopause transition, it is important to monitor mood, blood pressure, lipids, blood sugars, and body composition because of the increased risk of abdominal fat.

“Healthy eating and exercise are encouraged, with individualised discussion about benefits and risks of hormone therapy,” the Dr. added.

For the findings, published in the journal, the team examined 138 menopausal women for the association of mood, symptoms, and quality of life measures with the key markers of vascular aging, a major risk factor for the development of cardiovascular disease.

In addition, across the stages of menopause, arterial stiffening and vascular dysfunction were associated with more frequent and severe menopause symptoms and a lower quality of life.
No association, however, was found with depressive symptoms.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                                                                                                                                      PS- THOSE INTERESTED IN RECIPES ARE FREE TO VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/   
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