Hypertension can hinder clearance of waste molecules of brain
As part of a recent study, researchers have found that high blood
pressure may affect conditions such as Alzheimer's disease by
interfering with the brain's waste management system.
According to the findings, hypertension causes stiffening and elasticity loss in blood vessels, which hinders the clearance of waste molecules from the brain. Using a rat model of hypertension, a team of researchers, studied how the condition affects the movement of cerebrospinal fluid into and interstitial fluid out of brain cells.
According to the findings, hypertension causes stiffening and elasticity loss in blood vessels, which hinders the clearance of waste molecules from the brain. Using a rat model of hypertension, a team of researchers, studied how the condition affects the movement of cerebrospinal fluid into and interstitial fluid out of brain cells.
The researchers tracked
the flow of cerebrospinal fluid and found that the hypertensive rats
exhibited larger ventricles, decreased brain volume, and impaired fluid
transport.
They concluded that hypertension interferes with the clearance of macro-molecules from the brain, such as the Alzheimer's pathology protein b-amyloid. Treatments targeting hypertension could, in turn, reduce b-amyloid buildup and delay the onset of Alzheimer's disease.
They concluded that hypertension interferes with the clearance of macro-molecules from the brain, such as the Alzheimer's pathology protein b-amyloid. Treatments targeting hypertension could, in turn, reduce b-amyloid buildup and delay the onset of Alzheimer's disease.
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Labels: affects, Alzheimer's, arterial stiffening, blood vessel, brain's waste, causes, cerebrospinal fluid, clearance, elasticity loss, hinders, hypertension, interferes, interstitial fluid, management system
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