Antioxidants found in green tea can destroy antibiotic-resistant bacteria

Green tea's antioxidant properties are well known but recent research has found that it is also beneficial in getting rid of antibiotic-resistant bacteria. It is now a proven fact that antioxidant commonly found in green tea can terminate antibiotic-resistant bacteria.

The findings were published in the Journal of Medical Microbiology in which the researchers found that epigallocatechin (EGCG) can restore the activity of aztreonam, an antibiotic commonly used to treat infections caused by the bacterial pathogen -- Pseudomonas aeruginosa.

P. aeruginosa is associated with serious respiratory tract and bloodstream infections and has become resistant to many major classes of antibiotics over the years. Currently, a combination of antibiotics is used to fight P. aeruginosa. However, these infections are becoming increasingly difficult to treat, as resistance to last-line antibiotics is being observed.

To assess the synergy of EGCG and aztreonam, researchers conducted in vitro tests to analyse how they interacted with the bacterial pathogen individually and in combination. The team found that the combination of aztreonam and EGCG was significantly more effective at reducing P. aeruginosa numbers than either agent alone.

This synergistic activity was also confirmed in vivo using Galleria mellonella (Greater Wax Moth larvae), with survival rates being significantly higher in those treated with the combination than those treated with EGCG or aztreonam alone. Furthermore, minimal to no toxicity was observed in human skin cells and Galleria mellonella larvae.

Researchers believe that in P. aeruginosa, EGCG may facilitate increased uptake of aztreonam by increasing permeability in the bacteria. Another potential mechanism is EGCG's interference with a biochemical pathway linked to antibiotic susceptibility.

"Antimicrobial resistance (AMR) is a serious threat to global public health. Without effective antibiotics, the success of medical treatments will be compromised. Natural products such as EGCG, used in combination with currently licenced antibiotics, maybe a way of improving their effectiveness and clinically useful lifespan," said lead author Dr Jonathan Betts, Senior Research Fellow in the School of Veterinary Medicine at the University of Surrey.

"The World Health Organisation has listed antibiotic-resistant Pseudomonas aeruginosa as a critical threat to human health. We have shown that we can successfully eliminate such threats with the use of natural products, in combination with antibiotics already in use," said Professor Roberto La Ragione, Head of the Department of Pathology and Infectious Diseases in the School of Veterinary Medicine at the University of Surrey.

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Could green tea reduce resistance to antibiotics?

Green is already known for its antioxidant properties but did you know that it can prove beneficial in getting rid of antibiotic-resistant bacteria.

Yes! Researchers have discovered that a natural antioxidant commonly found in green tea can help eliminate antibiotic-resistant bacteria.

The findings were published in the Journal of Medical Microbiology in which the researchers found that epigallocatechin (EGCG) can restore the activity of aztreonam, an antibiotic commonly used to treat infections caused by the bacterial pathogen -- Pseudomonas aeruginosa.

P. aeruginosa is associated with serious respiratory tract and bloodstream infections and has become resistant to many major classes of antibiotics over the years.

Currently, a combination of antibiotics is used to fight P. aeruginosa. However, these infections are becoming increasingly difficult to treat, as resistance to last-line antibiotics is being observed.
To assess the synergy of EGCG and aztreonam, researchers conducted in vitro tests to analyse how they interacted with the bacterial pathogen individually and in combination.

The team found that the combination of aztreonam and EGCG was significantly more effective at reducing P. aeruginosa numbers than either agent alone.

This synergistic activity was also confirmed in vivo using Galleria mellonella (Greater Wax Moth larvae), with survival rates being significantly higher in those treated with the combination than those treated with EGCG or aztreonam alone. Furthermore, minimal to no toxicity was observed in human skin cells and in Galleria mellonella larvae.

Researchers believe that in P. aeruginosa, EGCG may facilitate increased uptake of aztreonam by increasing permeability in the bacteria. Another potential mechanism is EGCG's interference with a biochemical pathway linked to antibiotic susceptibility.

"Antimicrobial resistance (AMR) is a serious threat to global public health. Without effective antibiotics, the success of medical treatments will be compromised. Natural products such as EGCG, used in combination with currently licenced antibiotics, maybe a way of improving their effectiveness and clinically useful lifespan," said lead author .

"The World Health Organisation has listed antibiotic-resistant Pseudomonas aeruginosa as a critical threat to human health. We have shown that we can successfully eliminate such threats with the use of natural products, in combination with antibiotics already in use," said the Professor.

 this is only for your information, kindly take the advice of your doctor for medicines, exercises and so on.   
https://gscrochetdesigns.blogspot.com. one can see my crochet creations https://gseasyrecipes.blogspot.com. feel free to view for easy, simple and healthy recipes    
https://kneereplacement-stickclub.blogspot.com. for info on knee replacement  

These 3 Creepy Animals Can Save Human Lives

Wasps, spiders, and cockroaches may be creepy, but all 3 may soon be able to revolutionize medical research. Let’s all admit it, the majority of people have a difficult relationship with most arthropods. One of the most common phobias in the world is arachnophobia, the fear of spiders (and other arachnids such as scorpions), so that relationship has gone downhill before it had a chance to start. The story with insects is very similar: we consider a lot of them to be pests, and the rest are just some strange alien creatures that just happen to live on the same planet with us. Little did we know that these creepy-crawlies may hold the key to the medical research of the future.

1. Spiders

Although arachnid research in the field of medicine is still in the developing stages, scientists managed to isolate two main resources (spider venom and spider silk) that could potentially transform the way we treat certain conditions.
Spider venom, in particular, has been tested as an experimental treatment of pain caused by IBS (irritable bowel syndrome), as well as a substance that could potentially treat epileptic seizures.
More specifically, an Australian research team has managed to isolate a protein from the venom of a species of tarantula, Heteroscodra maculata, that can block the pain signals from the intestines to the central nervous system. The researchers then developed a treatment that was shown to inhibit IBS-related pain, at least in animal models. A different Australian research group looked at how a peptide isolated from spider venom can potentially help treat seizures in Dravet’s syndrome, a severe type of epilepsy characterized by an extreme sensitivity to high temperatures. 
Spider silk is the strongest biological material on the planet, not to mention it’s very flexible and light, no wonder researchers are looking at its potential to be used in sutures and bandages, as well as medical devices and prosthetics. A research team antiobiotic resistantpromises to come up with a new generation of spider silk-based materials that may soon transform not only medical supplies but also protective and sports equipment.

2. Cockroaches

Cockroaches may be a pest in your mind, which they definitely are, but medical science found a use even for these creepy creatures. Some researchers plan on using them as a cheaper alternative to common lab animals, like mice, in some experiments, whereas others claim the cockroach brain may hold the secret to treatment for antibiotic-resistant bacteria.

In fact, in China, there are entire cockroach-breeding farms, as ground-up cockroaches are believed to treat gastrointestinal problems. Also, a research team in the UK found that the brains of cockroaches and locusts contain at least 9 different compounds that could potentially kill drug-resistant bacteria.

The researchers hope one of these compounds may be the key to a cure for infections caused by such increasingly-resistant bacteria, like Escherichia coli and MRSA.

3. Wasps

A fear of wasps is completely warranted, as their stings can be not only spontaneous and extremely painful, but also commonly cause allergic reactions. But, as it often happens in medicine, toxic substances may hide a secret medical use that may save lives in the future.

In the case of wasp and hornet venom, there are at least 2 different compounds that may open the door to medical innovation. The most-studied compound is mastoparan, a peptide that can be found in the venom of different species of wasps and hornets. Mastoparan has been found to have antimicrobial, antibiotic and even anti-cancer properties, but there is a catch.

It turns out that, while mastoparan does kill the harmful bugs and makes certain tumors vanish, it is toxic to the healthy cells as well, so the next hurdle in clinical research is a more targeted treatment. Finally, a different type of peptides (ampulexins) from the venom of emerald jewel wasps, on the other hand, are currently reviewed as a potential treatment of Parkinson’s disease.

As you can tell, the majority of these research projects are a work in progress, but it’s fun to entertain the idea of these arthropods saving human lives nevertheless. It would be an unexpected turn of events to find yourself in a situation where you owe your health to a creature you despise, wouldn’t it?

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