Tuesday, December 04, 2018

World’s first baby born via womb transplant from dead donor

A woman in Brazil who received a womb, transplanted from a deceased donor, has given birth to a baby girl in the first successful case of its kind, doctors reported. The case,  involved connecting veins from the donor uterus with the recipient’s veins, as well as linking arteries, ligaments and vaginal canals.
It comes after 10 previously known cases of uterus transplants from deceased donors — in the United States, the Czech Republic and Turkey — failed to produce a live birth.

The girl born in the Brazilian case was delivered via caesarean section at 35 weeks and three days, and weighed 2,550 grams (nearly 6 lbs), the case study said.


A doctor who led the research, said the transplant – carried out in September 2016 when the recipient was 32 – shows the technique is feasible and could offer women with uterine infertility access to a larger pool of potential donors.

The current norm for receiving a womb transplant is that the organ would come from a live family member willing to donate it.

“The numbers of people willing and committed to donate organs upon their own deaths are far larger than those of live donors, offering a much wider potential donor population,” the Dr. said in a statement about the results.

She added, however, that the outcomes and effects of womb donations from live and deceased donors have yet to be compared, and said the technique could still be refined and optimised.

The first baby born after a live donor womb transplant was in Sweden in 2013. Scientists have so far reported a total of 39 procedures of this kind, resulting in 11 live births.

Experts estimate that infertility affects around 10 to 15 percent of couples of reproductive age worldwide. Of this group, around one in 500 women have uterine problems.

Before uterus transplants became possible, the only options to have a child were adoption or surrogacy.

In the Brazilian case, the recipient had been born without a uterus due to a condition called Mayer-Rokitansky-Küster-Hauser syndrome. The donor was 45 and died of a stroke.

Five months after the transplant, the team wrote, the uterus showed no signs of rejection, ultrasound scans were normal, and the recipient was having regular menstruation. The woman’s previously fertilised and frozen eggs were implanted after seven months and 10 days later she was confirmed pregnant.

At seven months and 20 days – when the case study report was submitted – the baby girl was continuing to breastfeed and weighed 7.2 kg (16 lb).

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Saturday, April 22, 2017

Doctors in Pune Are All Set to Perform India’s First Womb Transplants

In what’s likely to be a groundbreaking medical procedure conducted in India, Pune’s Galaxy Care Laparoscopy Institute (GCLI) is all set to be the first hospital in the country to conduct uterine transplants.

The hospital has scheduled for three uterine transplants (wherein three women will be given the womb of their mothers so they can themselves bear children) in about three weeks’ of time. These transplants are extremely rare and only 25 of them have been conducted across the world so far (out of this there only 10 known successful post surgery pregnancies).

The first transplant was conducted in 2014 in Sweden.

GCLI medical director and oncosurgeon Dr Shailesh Puntambekar who is heading the team said that one of the women who will be getting a womb has a congenital absence of uterus. He added, “Another one suffers from scarring (adhesion) of the uterus (Asherman’s syndrome) and the other woman’s uterus was removed due to cancer three years ago. The donors are their own mothers and the first transplants are going to be conducted for free.”

In order to prepare for these path-breaking surgeries, the team trained in Germany and in the United States. They also learnt the protocol from the Swedish team that first conducted this transplant successfully. The hospital is also working closely with the Dr Mats Bronnstrom of the University of Gothenburg in Sweden, considered the pioneer in this field.

Currently, there is another centre in India, the Milann-International Institute for Training and Research in Reproductive Health in Bengaluru, that has also gotten the permission to conduct these transplants on two women but given the scheduling, GCLI is most likely to conduct the procedure first.

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