Saturday, December 15, 2018

The first cry of joy

An early September night in 2014, together with the rest of the team behind the Swedish uterus transplant trial, the Dr. prepared for a landmark delivery. The birth of a baby that would transform both the fields of reproductive and transplantation medicine. This was the groundbreaking finale—a culmination of a ten-year journey and preparatory work in different animal models.

The mother-to-be had, a year and a half earlier, received a donated uterus from a family friend. A friend who, at the time of the uterus donation, had been postmenopausal for ten years. The mother-to-be was born without a uterus because of a condition called Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. As a teenager, she was told by her doctors that she would never be able to carry her own pregnancy and give birth to a child.

That September night we were to prove this previous statement wrong. Her pregnancy had been without any complications until she developed signs of preeclampsia in the 31st week of pregnancy. As this was the first successful pregnancy, the team didn’t dare to wait, and we decided to deliver the baby boy prematurely. It was completely silent in the operating room until the most beautiful cry filled the room. There was awe, relief and joy. We knew at that time that we created hope for millions of women in the world affected by uterine factor infertility, a new hope to be able to give birth.

Since that first birth in 2014, at least 12 more babies around the world have been born to mothers following uterine transplantation. I have been fortunate to be the only doctor in the world to be involved with not only the first uterus transplant centre that delivered a baby, but also the second one. At another medical centre, the team was successful in replicating the successes of my former Swedish team when we, in 2017, delivered the first baby after uterus transplant in the US and outside of the Swedish trial.

To work as a uterus transplant surgeon means facing novel medical and surgical questions. It means balancing a field that is an intersect between transplantation, gynaecology, reproductive medicine, pathology, radiology and new ethical challenges. Since the onset of the first uterus transplant trial, the discussions in the medical community have morphed from questioning the need for uterus transplantation and its possibility to improving the procedure and outcome, and finally to discussions of financing, organ allocation and clinical implications. Always keeping the Hippocratic oath close to heart and remembering that 'Primum non nocere' (first, to do no harm) in this procedure is applicable to both donor and recipient.

A uterus transplantation is not a lifesaving or even life-prolonging procedure. Nonetheless, by restoring a bodily function lost or missing, it is instead a thoroughly life promoting procedure—creating life where none could grow before.

I believe that this truly beautiful procedure will now bring joy in India for many mothers-to-be, and I congratulate the team for their achievement.

ps- as told by the Dr. who was involved in both the 1st and the 2nd uterus transplant successfully and delivery of the baby.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                                                                                                                                                                                                                        PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                                             FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                                                                                             https:// kneereplacement-stickclub.blogspot.com/                                                                                       FOR CROCHET DESIGNS                                                                                                                                                                                                                                 https://gscrochetdesigns.blogspot.com   

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Tuesday, December 04, 2018

World’s first baby born via womb transplant from dead donor

A woman in Brazil who received a womb, transplanted from a deceased donor, has given birth to a baby girl in the first successful case of its kind, doctors reported. The case,  involved connecting veins from the donor uterus with the recipient’s veins, as well as linking arteries, ligaments and vaginal canals.
It comes after 10 previously known cases of uterus transplants from deceased donors — in the United States, the Czech Republic and Turkey — failed to produce a live birth.

The girl born in the Brazilian case was delivered via caesarean section at 35 weeks and three days, and weighed 2,550 grams (nearly 6 lbs), the case study said.


A doctor who led the research, said the transplant – carried out in September 2016 when the recipient was 32 – shows the technique is feasible and could offer women with uterine infertility access to a larger pool of potential donors.

The current norm for receiving a womb transplant is that the organ would come from a live family member willing to donate it.

“The numbers of people willing and committed to donate organs upon their own deaths are far larger than those of live donors, offering a much wider potential donor population,” the Dr. said in a statement about the results.

She added, however, that the outcomes and effects of womb donations from live and deceased donors have yet to be compared, and said the technique could still be refined and optimised.

The first baby born after a live donor womb transplant was in Sweden in 2013. Scientists have so far reported a total of 39 procedures of this kind, resulting in 11 live births.

Experts estimate that infertility affects around 10 to 15 percent of couples of reproductive age worldwide. Of this group, around one in 500 women have uterine problems.

Before uterus transplants became possible, the only options to have a child were adoption or surrogacy.

In the Brazilian case, the recipient had been born without a uterus due to a condition called Mayer-Rokitansky-Küster-Hauser syndrome. The donor was 45 and died of a stroke.

Five months after the transplant, the team wrote, the uterus showed no signs of rejection, ultrasound scans were normal, and the recipient was having regular menstruation. The woman’s previously fertilised and frozen eggs were implanted after seven months and 10 days later she was confirmed pregnant.

At seven months and 20 days – when the case study report was submitted – the baby girl was continuing to breastfeed and weighed 7.2 kg (16 lb).

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                                                                                                                                                                                                                                                                        PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                                             FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                                                                                             https:// kneereplacement-stickclub.blogspot.com/                                                                                       FOR CROCHET DESIGNS                                                                                                                                                                                                                                 https://gscrochetdesigns.blogspot.com

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