High-fibre diet cuts preeclampsia risk during pregnancy

Ladies, please take note. Consuming a high fibre-diet may reduce the risk of preeclampsia during pregnancy, researchers have found.

Simple recommendation to eat food, mostly plants and not too much, might be the most effective primary prevention strategy for some of the most serious conditions of our time.

The mother's gut bacteria and diet appear to be crucial to promoting healthy pregnancy, said the lead author of the study.

The study showed that pregnancy outcomes and infant immunity are linked to gut bacteria.

Plant-based fibre is broken down in the gut by bacteria into factors that influence the immune system. The research team investigated the role of these metabolic products of gut bacteria during pregnancy.

The researchers found that in humans, reduced levels of acetate, which is mainly produced by fibre fermentation in the gut, is associated with the common and serious pregnancy-related condition, preeclampsia.

Preecelampsia occurs in up to 10% of pregnancies and is characterised by high blood pressure, protein in the urine and severe swelling in the mother's body.

It also interferes with the child's immune development whilst in the womb, with some evidence suggesting a link to higher rates of allergies and autoimmune diseases later in life.

The study found that preeclampsia affected the development of an important fetal immune organ-the thymus- which sits just behind the breastbone.

Foetuses in preeclampsia pregnancies were found to have a much smaller thymus than children from healthy pregnancies.

The cells the thymus normally generates-called T cells, and specifically those associated with the prevention of allergies and autoimmune conditions such as diabetes- also remained lower in infants after preeclampsia, even 4 years after delivery.

The mechanism of acetate on the developing foetal immune system were further examined in separate experiments involving mice that showed acetate was central in driving foetal thymus and T cell development.

The results showed that promoting specific metabolic products of gut bacteria during pregnancy might be an effective way to maintain a healthy pregnancy and to prevent allergies and autoimmune conditions later in life.

THIS IS ONLY FOR INFORMATION, ALWAYS CONSULT YOU PHYSICIAN BEFORE HAVING ANY PARTICULAR FOOD/ MEDICATION/EXERCISE/OTHER REMEDIES.                                    PS- THOSE INTERESTED IN RECIPES ARE FREE TO  VIEW MY BLOG-                                                                                           https://gseasyrecipes.blogspot.com/                                                                                                                                                FOR INFO ABOUT KNEE REPLACEMENT, YOU CAN VIEW MY BLOG-                                                  https:// kneereplacement-stickclub.blogspot.com/                                                                      FOR CROCHET DESIGNS                                                                                                                                                                                     https://gscrochetdesigns.blogspot.com

Ladies, please take note. Consuming a high-fibre diet may reduce the risk of preeclampsia during pregnancy, researchers have found. "Simple recommendation to 'eat real food, mostly plants and not too much' might be the most effective primary prevention strategy for some of the most serious conditions of our time. "The mother's gut bacteria and diet appear to be crucial to promoting healthy pregnancy," said study lead author Ralph Nanan, Professor at the University of Sydney. https://www.thehansindia.com/life-style/health/high-fibre-diet-cuts-preeclampsia-risk-during-pregnancy-545735

https://www.thehansindia.com/life-style/health/high-fibre-diet-cuts-preeclampsia-risk-during-pregnancy-545735

Aging immune system may explain age-related cancer risk increase

The key to cancer prevention may lie in the immune system rather than genetic mutations, the current focus of most anti-cancer efforts across the world, according to a major new study carried out recently.

Eight million people die of cancer across the world each year. Men are significantly more likely than women to be diagnosed with cancer in their lifetime, and for most cancers the chance of developing the disease rises dramatically with age.

For decades, it has been known that mutations arising either as a result of genetic predisposition, or lifestyle and environmental factors cause cancer. The traditional view is that the way cancer incidence increases with age could be understood and quantified if multiple (typically five to six) mutations in one cell are required to initiate cancer.

The researchers have shown that the declining immune system with age may actually be a stronger reason for the increasing incidence of developing cancer than multiple mutations.

Following the hypothesis that an ageing immune system may result in higher rates of cancer, just as it leads to older people being more prone to other diseases, they looked at data on 2 million cases of cancer over the 18-70 age range. They then developed a mathematical equation for how they would expect cancer incidence to rise in relation to a declining immune system and compared it to the age profiles for 100 different cancers.

Their model fitted the data better than the multiple mutation hypothesis. Because the immune system generally declines more slowly in women than men, they were also able to account for the gender difference in cancer incidence, something that mutations alone cannot easily explain.

This suggests that the immune system, particularly as it declines, may play a far bigger role in the development of cancer than previously thought. If borne out by further studies, this could have significant implications for cancer prevention and treatment across the globe.

"This is still very early days but if we are proven right then you could be talking about a whole new way to treat and prevent cancer," said the senior author of the study.

"Nearly all of the mainstream research into cancer is based on how we can understand genetic mutations, target them and thereby cure the disease. We're not debating the fact that mutations cause cancer, but are asking whether mutations alone can account for the rapid rise in cancer incidence with age when ageing causes other profound changes in the body."

A primary cause of immune system ageing is the shrinking of the thymus gland. This is where T cells, which circulate the body killing dysfunctional cells or foreign agents, are produced.

Thymic involution begins from around the age of one and the thymus roughly halves in size every 16 years, with a corresponding fall in the production of T cells. The researchers found an extremely strong correlation between the chances of certain cancers increasing and the new T cell populations falling.

"The immunosurveillance hypothesis is that cancer cells are continually arising in the body but that normally the immune system kills them before a new tumour is able to establish itself," said a Dr.  who initiated the research.

"The T cells are constantly scanning for cancer cells, looking to destroy them. If they can't find them soon enough or the immune system is weak then the cancer population has the chance to grow. The chances of this happening will increase with age as the thymus is shrinking all the time.

"For our model, we imagined a war between T cells and cancer cells, which the cancer cells win if they grow beyond a certain threshold. We then set this threshold to be declining with age, proportional to T cell production. This simple hypothesis turns out to be able to explain much of the cancer incidence data."

A Dr.  added, "The increase of cancer incidence with age is slower in women, something which we would naively expect to be effectively gender-neutral. However, the thymus gland shrinks more slowly in women, so we were able to make a prediction on the differential cancer incidence with gender that once again shows our model to be more accurate than the traditional model."

The team tested their model on data from a programme. The results showed that many cancers appear to be very strongly linked to the decline of the immune system, while others are more likely linked to a combination of immune system decline and multiple mutations.

An expert in thymus biology, said, "We believe that our findings are extremely relevant and show the need to take the immune system even more seriously in cancer research.

"In addition to mutations, this suggests we should also focus on how to boost thymus function in a controlled way, perhaps by transplantation or by controlled regeneration, so we can increase the number of T cells we are making. Of course, we also need to look at whether there may be unintended consequences of doing this, and how to minimise these if they occur."

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