Tobacco plant may aid in treating diabetes, arthritis

Tobacco plants can be used to produce an anti-inflammatory protein that can have powerful therapeutic potential for treating conditions like Type-2 diabetes, stroke, dementia and arthritis, more effectively and at an affordable price, researchers say.

A team of researchers used tobacco plants to produce large quantities of a human protein called Interleukin 37, or IL-37 — naturally produced in the human kidney in very small quantities.

“This protein is a master regulator of inflammation in the body, and has been shown in pre-clinical models to be effective in treating a whole host of inflammatory and autoimmune diseases,” said a Professor.

“The human kidney produces IL-37, but not nearly enough to get us out of an inflammation injury.”

While IL-37 has shown promise in animal models, it’s use clinically has been limited because of the inability to produce it in large quantities at a price that is feasible clinically. Currently, it can be made in very small amounts using the bacteria E. coli, but at a very high cost.

That’s where the tobacco plants come in and pave the way to provide treatments that are effective and affordable, according to the study published recently.

“The plants offer the potential to produce pharmaceuticals in a way that is much more affordable than current methods,” said  a scientist.

“Tobacco is high-yield, and we can temporarily transform the plant so that we can begin making the protein of interest within two weeks.”

The team is now investigating the effect that IL-37 has for preventing organ injury during transplantation. When an organ is removed for transplantation and then transferred to a recipient, inflammation occurs when the blood flow is restored to the organ.

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SCIENTISTS SAY THAT TURMERIC HELPS TO FIGHT CANCER IN CHILDREN !

The health benefits of turmeric – a spice found and used extensively in  households around the world.

Often referred to as the 'Queen of Spices', turmeric has been generously used in almost everything, from treating colds and cough to wounds to skin infections.

A number of studies have also shown that turmeric has therapeutic properties – from boosting immunity to being anti-inflammatory and antioxidant, thanks to a compound called 'curcumin' present in the spice.

Now, scientists have further raised the status of turmeric, while also establishing the healing properties of curcumin saying that, it can cure cancer in children.

Researchers have found that nanoparticles loaded with curcumin can offer a novel treatment to target and destroy neuroblastoma tumour cells. Neuroblastoma is the most common cancer in children younger than five years old.

High-risk neuroblastoma can be resistant to traditional therapy, and survival can be poor. The cancers start in early nerve cells and commonly form in the tissue of the adrenal glands, near the kidneys. They are also associated with developmental delays, hearing loss, or other disabilities even after traditional treatments have ended.

In their study, the researchers attached curcumin to cerium oxide nanoparticles and tested the nano-curcumin formulation in cell lines of a high-risk form of neuroblastoma.

"This formulation induced substantial cell death in neuroblastoma cells while producing no or only minor toxicity in healthy cells," says their report.

Curcumin has been shown to have substantial anti-cancer ability, but its low solubility and poor stability have restricted its use in therapeutic applications.

According to the study conducted by its scientists demonstrates a novel method of treating this tumour "without the toxicity of aggressive therapy" and shows that nanoparticles can be "an effective delivery vehicle" for cancer drugs.

"We are hopeful that in the future, nanoparticles can be utilised to personalise care to patients and reduce the late effects of therapy."

The fact that curcumin, when formulated as nanoparticles, is able to increase its bioavailability and thereby improve its therapeutic ability has earlier been shown by scientists as well in the case of tuberculosis (TB).
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Tulsi is envisioned to yield ways to new Medicines, says Experts

Indian experts have sequenced the full genome of tulsi in a research.
 
They said, Tulsi is intended to yield pathways to new medicines from this medicinal herb revered for centuries by several systems of medicine. All parts of this herb the dried leaves, the dried whole plant and seeds are used in several systems of traditional medicine, including Ayurveda, Greek, Roman, Siddha, and Unani. Tulsi is considered holy in India.

Holy Basil is rich in organic compounds such as phenylpropanoids and terpenoids which are known to have therapeutic properties. The availability of the genome sequence now opens the possibility of identifying genes involved in producing therapeutic molecules and to produce them in vitro (in the lab) according to CSIR.
The researchers in a government laboratory in Lucknow and a private genome sequencing centre in Bangalore have generated a draft sequence of the 386 million genetic alphabets that make up the full genome of Ocimum sanctum, the botanical name for tulsi.
“This will also facilitate identification of not-yet-identified genes involved in the synthesis of important secondary metabolites in this plant,” said a press release issued by CSIR.

Leaf tissues of basil were collected from the experimental farm at the CSIR-Central Institute of Medicinal and Aromatic Plants based in Lucknow. The genomic DNA was isolated from the leaves of basil and was analysed for its concentration and integrity.

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