New drug cuts fat in rats, may help reduce obesity in humans

If you want to shed some weight without starving yourself, then there may be a sigh of relief for you as researchers are developing a new drug that shrinks your fat without suppressing appetite.
The new drug selectively shrinks excess fat by increasing fat cell metabolism, according to the researchers.
The researchers discovered a molecule that blocks metabolic brake from operating in obese white fat cells. By blocking this metabolic brake, they were able to increase the metabolism within white fat cells.
"Blocking the action of the fat cell brake provides an innovative 'fat' specific mechanism to increase cell metabolism and reduce the size of white fat deposits, thereby treating a root cause of obesity and related metabolic diseases," said the lead author of the study.

According to a recent study, published in the journal , the drug significantly reduces body weight and blood cholesterol levels without lowering food intake in obese mice.

In the study, mice were fed a high-fat diet until they became obese and then received either the drug or a placebo.

Following 10 days of drug treatment, researchers found that the obese mice receiving the actual drug lost more than seven per cent of their total body weight and their white fat tissue mass and cell size decreased by 30 per cent compared with the placebo group.

In addition, blood cholesterol in drug-treated mice were lowered to normal levels, similar to those of non-obese mice.

On the contrary, placebo-treated mice continued to accumulate white fat and gain weight throughout the study.

Interestingly, mice in both the drug-treated and placebo groups consumed the same amount of food during the course of the study period, showing that the fat loss was not due to appetite suppression.

"These initial results are encouraging and support further development of this technology as a new and more effective approach to combating metabolic diseases," the researcher noted.


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Soon, drugs to starve cancer to death

Scientists believe that cancer could be cured by starving tumours to death.

The key may be a newly identified protein, eEF2K, which helps cancer cells to thrive but can 

be shut off without causing ill effects, the Daily Express reported.

A team of researchers are now experimenting with various drugs to block the work of this 

protein.

 A Professor  said that cancer cells grow and divide much more rapidly than normal cells, 

meaning they have a much higher demand for and are often starved of, nutrients and 

oxygen.

A cellular component, eEF2K, plays a critical role in allowing cancer cells to survive nutrient 

starvation, while normal, healthy cells do not usually require eEF2K in order to survive.

Therefore, by blocking the function of eEF2K, we should be able to kill cancer cells, without 

harming normal, healthy cells in the process.

Hopes are that the treatment will be available within five years.

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